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Oxidation of PAH trans-Dihydrodiols by Human Aldo-Keto Reductase AKR1B10

Chemical research in toxicology, 2008-11, Vol.21 (11), p.2207-2215

2008

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Regiospecific oxidation of polycyclic aromatic phenols to quinones by hypervalent iodine reagents

Tetrahedron, 2010-03, Vol.66 (12), p.2111-2118

2010

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Evidence for the Aldo-Keto Reductase Pathway of Polycyclic Aromatic Trans-Dihydrodiol Activation in Human Lung A549 Cells

Proceedings of the National Academy of Sciences - PNAS, 2008-05, Vol.105 (19), p.6846-6851

2008

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Synthesis of polycyclic xanthenes and furans via palladium-catalyzed cyclization of polycyclic aryltriflate esters

Tetrahedron, 2002-07, Vol.58 (29), p.5927-5931

2002

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Metabolism of Benzo[a]pyrene in Human Bronchoalveolar H358 Cells Using Liquid Chromatography–Mass Spectrometry

Chemical research in toxicology, 2007-09, Vol.20 (9), p.1331-1341

2007

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Polycyclic Aromatic Hydrocarbon (PAH) o-Quinones Produced by the Aldo-Keto-Reductases (AKRs) Generate Abasic Sites, Oxidized Pyrimidines, and 8-Oxo-dGuo via Reactive Oxygen Species

Chemical research in toxicology, 2006-05, Vol.19 (5), p.719-728

2006

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Regulation of Benzo[a]pyrene-Mediated DNA- and Glutathione-Adduct Formation by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Human Lung Cells

Chemical research in toxicology, 2011-01, Vol.24 (1), p.89-98

2011

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Synthesis of Phenol and Quinone Metabolites of Benzo[a]pyrene, a Carcinogenic Component of Tobacco Smoke Implicated in Lung Cancer

Journal of organic chemistry, 2009-01, Vol.74 (2), p.597-604

2009

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Synthesis of the o-Quinones and Other Oxidized Metabolites of Polycyclic Aromatic Hydrocarbons Implicated in Carcinogenesis

Journal of organic chemistry, 2004-03, Vol.69 (6), p.2024-2032

2004

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Aldo−Keto Reductase- and Cytochrome P450-Dependent Formation of Benzo[a]pyrene-Derived DNA Adducts in Human Bronchoalveolar Cells

Chemical research in toxicology, 2007-03, Vol.20 (3), p.424-431

2007

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Expression and Characterization of Four Recombinant Human Dihydrodiol Dehydrogenase Isoforms: Oxidation of trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene to the Activated o-Quinone Metabolite Benzo[a]pyrene-7,8-dione

Biochemistry (Easton), 1998-05, Vol.37 (19), p.6781-6790

1998

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Substituent Effects in Benz[a]anthracene Carbocations: A Stable Ion, Electrophilic Substitution (Nitration, Bromination), and DFT Study

Journal of organic chemistry, 2007-08, Vol.72 (18), p.6768-6775

2007

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Quantification of benzo[a]pyrene diol epoxide DNA-adducts by stable isotope dilution liquid chromatography/tandem mass spectrometry

Rapid communications in mass spectrometry, 2006-01, Vol.20 (8), p.1369-1380

2006

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Generation of Reactive Oxygen Species during the Enzymatic Oxidation of Polycyclic Aromatic Hydrocarbon trans-Dihydrodiols Catalyzed by Dihydrodiol Dehydrogenase

Chemical research in toxicology, 1996-01, Vol.9 (1), p.84-92

1996

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Aryl Hydrocarbon Receptor Facilitates DNA Strand Breaks and 8-Oxo-2′-deoxyguanosine Formation by the Aldo-Keto Reductase Product Benzo[a]pyrene-7,8-dione

The Journal of biological chemistry, 2009-10, Vol.284 (43), p.29725-29734

2009

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Quantitation of Benzo[a]pyrene Metabolic Profiles in Human Bronchoalveolar (H358) Cells by Stable Isotope Dilution Liquid Chromatography–Atmospheric Pressure Chemical Ionization Mass Spectrometry

Chemical research in toxicology, 2011-11, Vol.24 (11), p.1905-1914

2011

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Detoxication of Structurally Diverse Polycyclic Aromatic Hydrocarbon (PAH) o-Quinones by Human Recombinant Catechol-O-methyltransferase (COMT) via O-Methylation of PAH Catechols

The Journal of biological chemistry, 2011-07, Vol.286 (29), p.25644-25654

2011

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Efficient syntheses of C(8)-aryl adducts of adenine and guanine formed by reaction of radical cation metabolites of carcinogenic polycyclic aromatic hydrocarbons with DNA

Journal of organic chemistry, 2007-06, Vol.72 (13), p.4856

2007

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Synthesis of 13C2-benzo[a]pyrene and its 7,8-dihydrodiol and 7,8-dione implicated as carcinogenic metabolites

Tetrahedron letters, 2008-07, Vol.49 (29-30), p.4531-4533

2008

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Efficient Syntheses of C 8-Aryl Adducts of Adenine and Guanine Formed by Reaction of Radical Cation Metabolites of Carcinogenic Polycyclic Aromatic Hydrocarbons with DNA

Journal of organic chemistry, 2007-06, Vol.72 (13), p.4856-4863

2007

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Activation of polycyclic aromatic hydrocarbon trans-dihydrodiol proximate carcinogens by human aldo-keto reductase (AKR1C) enzymes and their functional overexpression in human lung carcinoma (A549) cells

The Journal of biological chemistry, 2002-07, Vol.277 (27), p.24799-24808

2002

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Metabolism and Distribution of Benzo[a]pyrene-7,8-dione (B[a]P-7,8-dione) in Human Lung Cells by Liquid Chromatography Tandem Mass Spectrometry: Detection of an Adenine B[a]P-7,8-dione Adduct

Chemical research in toxicology, 2012-05, Vol.25 (5), p.993-1003

2012

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Polycyclic Aromatic Hydrocarbon o-Quinones Inhibit the Activity of the Catalytic Fragment of Protein Kinase C

Biochemistry (Easton), 2002-10, Vol.41 (39), p.11888-11894

2002

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Disposition and Biological Activity of Benzo[a]pyrene-7,8-dione. A Genotoxic Metabolite Generated by Dihydrodiol Dehydrogenase

Biochemistry (Easton), 1996-10, Vol.35 (42), p.13664-13672

1996

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The Ubiquitous Aldehyde Reductase (AKR1A1) Oxidizes Proximate Carcinogen trans-Dihydrodiols to o-Quinones: Potential Role in Polycyclic Aromatic Hydrocarbon Activation

Biochemistry (Easton), 2001-09, Vol.40 (36), p.10901-10910

2001

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Oxidation of PAH trans-Dihydrodiols by Human Aldo-Keto Reductase AKR1B10

Regiospecific oxidation of polycyclic aromatic phenols to quinones by hypervalent iodine reagents

Evidence for the Aldo-Keto Reductase Pathway of Polycyclic Aromatic Trans-Dihydrodiol Activation in Human Lung A549 Cells

Synthesis of polycyclic xanthenes and furans via palladium-catalyzed cyclization of polycyclic aryltriflate esters

Metabolism of Benzo[a]pyrene in Human Bronchoalveolar H358 Cells Using Liquid Chromatography–Mass Spectrometry

Polycyclic Aromatic Hydrocarbon (PAH) o-Quinones Produced by the Aldo-Keto-Reductases (AKRs) Generate Abasic Sites, Oxidized Pyrimidines, and 8-Oxo-dGuo via Reactive Oxygen Species

Regulation of Benzo[a]pyrene-Mediated DNA- and Glutathione-Adduct Formation by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Human Lung Cells

Synthesis of Phenol and Quinone Metabolites of Benzo[a]pyrene, a Carcinogenic Component of Tobacco Smoke Implicated in Lung Cancer

Synthesis of the o-Quinones and Other Oxidized Metabolites of Polycyclic Aromatic Hydrocarbons Implicated in Carcinogenesis

Aldo−Keto Reductase- and Cytochrome P450-Dependent Formation of Benzo[a]pyrene-Derived DNA Adducts in Human Bronchoalveolar Cells

Expression and Characterization of Four Recombinant Human Dihydrodiol Dehydrogenase Isoforms: Oxidation of trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene to the Activated o-Quinone Metabolite Benzo[a]pyrene-7,8-dione

Substituent Effects in Benz[a]anthracene Carbocations: A Stable Ion, Electrophilic Substitution (Nitration, Bromination), and DFT Study

Quantification of benzo[a]pyrene diol epoxide DNA-adducts by stable isotope dilution liquid chromatography/tandem mass spectrometry

Generation of Reactive Oxygen Species during the Enzymatic Oxidation of Polycyclic Aromatic Hydrocarbon trans-Dihydrodiols Catalyzed by Dihydrodiol Dehydrogenase

Aryl Hydrocarbon Receptor Facilitates DNA Strand Breaks and 8-Oxo-2′-deoxyguanosine Formation by the Aldo-Keto Reductase Product Benzo[a]pyrene-7,8-dione

Quantitation of Benzo[a]pyrene Metabolic Profiles in Human Bronchoalveolar (H358) Cells by Stable Isotope Dilution Liquid Chromatography–Atmospheric Pressure Chemical Ionization Mass Spectrometry

Detoxication of Structurally Diverse Polycyclic Aromatic Hydrocarbon (PAH) o-Quinones by Human Recombinant Catechol-O-methyltransferase (COMT) via O-Methylation of PAH Catechols

Efficient syntheses of C(8)-aryl adducts of adenine and guanine formed by reaction of radical cation metabolites of carcinogenic polycyclic aromatic hydrocarbons with DNA

Synthesis of 13C2-benzo[a]pyrene and its 7,8-dihydrodiol and 7,8-dione implicated as carcinogenic metabolites

Efficient Syntheses of C 8-Aryl Adducts of Adenine and Guanine Formed by Reaction of Radical Cation Metabolites of Carcinogenic Polycyclic Aromatic Hydrocarbons with DNA

Activation of polycyclic aromatic hydrocarbon trans-dihydrodiol proximate carcinogens by human aldo-keto reductase (AKR1C) enzymes and their functional overexpression in human lung carcinoma (A549) cells

Metabolism and Distribution of Benzo[a]pyrene-7,8-dione (B[a]P-7,8-dione) in Human Lung Cells by Liquid Chromatography Tandem Mass Spectrometry: Detection of an Adenine B[a]P-7,8-dione Adduct

Polycyclic Aromatic Hydrocarbon o-Quinones Inhibit the Activity of the Catalytic Fragment of Protein Kinase C

Disposition and Biological Activity of Benzo[a]pyrene-7,8-dione. A Genotoxic Metabolite Generated by Dihydrodiol Dehydrogenase

The Ubiquitous Aldehyde Reductase (AKR1A1) Oxidizes Proximate Carcinogen trans-Dihydrodiols to o-Quinones: Potential Role in Polycyclic Aromatic Hydrocarbon Activation

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