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Structure-activity relationships for ruthenium and osmium anticancer agents - towards clinical development

Chemical Society reviews, 2018-02, Vol.47 (3), p.99-928

2018

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Biodistribution of the novel anticancer drug sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] KP-1339/IT139 in nude BALB/c mice and implications on its mode of action

Journal of inorganic biochemistry, 2016-07, Vol.160, p.250-255

2016

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Bioorganometallic chemistry--from teaching paradigms to medicinal applications

Chemical Society reviews, 2009-01, Vol.38 (2), p.391-401

2009

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Anticancer activity of metal complexes: involvement of redox processes

Antioxidants & redox signaling, 2011-08, Vol.15 (4), p.1085-1127

2011

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Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs

Chemical Society reviews, 2013-01, Vol.42 (14), p.6186-6199

2013

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Polynuclear ruthenium, osmium and gold complexes. The quest for innovative anticancer chemotherapeutics

Current topics in medicinal chemistry, 2011-11, Vol.11 (21), p.2688-2702

2011

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KP1019, A New Redox-Active Anticancer Agent - Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients

Chemistry & biodiversity, 2008-10, Vol.5 (10), p.2140-2155

2008

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The development of RAPTA compounds for the treatment of tumors

Coordination chemistry reviews, 2016-01, Vol.306, p.86-114

2016

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An Organoruthenium Anticancer Agent Shows Unexpected Target Selectivity For Plectin

Angewandte Chemie International Edition, 2017-07, Vol.56 (28), p.8267-8271

International ed. in English, 2017

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Antitumour metal compounds: more than theme and variations

Dalton transactions : an international journal of inorganic chemistry, 2008-01 (2), p.183-194

2008

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From bench to bedside – preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1 H-indazole)ruthenate(III)] (KP1019 or FFC14A)

Journal of inorganic biochemistry, 2006-05, Vol.100 (5), p.891-904

2006

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From Catalysis to Cancer: Toward Structure–Activity Relationships for Benzimidazol-2-ylidene-Derived N‑Heterocyclic-Carbene Complexes as Anticancer Agents

Inorganic chemistry, 2018-11, Vol.57 (22), p.14427-14434

2018

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Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action

Inorganic chemistry, 2018-03, Vol.57 (5), p.2851-2864

2018

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Unexpected arene ligand exchange results in the oxidation of an organoruthenium anticancer agent: the first X-ray structure of a protein-Ru(carbene) adduct

Chemical communications (Cambridge, England), 2018-06, Vol.54 (48), p.6120-6123

2018

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Emerging Protein Targets for Anticancer Metallodrugs: Inhibition of Thioredoxin Reductase and Cathepsin B by Antitumor Ruthenium(II)−Arene Compounds

Journal of medicinal chemistry, 2008-11, Vol.51 (21), p.6773-6781

2008

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A Combined Spectroscopic and Protein Crystallography Study Reveals Protein Interactions of RhI(NHC) Complexes at the Molecular Level

Inorganic chemistry, 2020-12, Vol.59 (23), p.17191-17199

2020

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The ruthenium(II)–arene compound RAPTA-C induces apoptosis in EAC cells through mitochondrial and p53–JNK pathways

Journal of biological inorganic chemistry, 2008-09, Vol.13 (7), p.1149-1155

2008

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Anticancer metallodrugs: where is the next cisplatin?

Future medicinal chemistry, 2018-03, Vol.10 (6), p.615-617

2018

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Characterization of the binding sites of the anticancer ruthenium(III) complexes KP1019 and KP1339 on human serum albumin via competition studies

Journal of biological inorganic chemistry, 2013-01, Vol.18 (1), p.9-17

2013

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Impact of the Metal Center and Leaving Group on the Anticancer Activity of Organometallic Complexes of Pyridine-2-carbothioamide

Molecules (Basel, Switzerland), 2021-02, Vol.26 (4), p.833

2021

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Making organoruthenium complexes of 8-hydroxyquinolines more hydrophilic: impact of a novel l-phenylalanine-derived arene ligand on the biological activity

Dalton transactions : an international journal of inorganic chemistry, 2018-02, Vol.47 (7), p.2192-2201

2018

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Platinum(terpyridine) complexes with N-heterocyclic carbene co-ligands: high antiproliferative activity and low toxicity in vivo

Dalton transactions : an international journal of inorganic chemistry, 2023-01, Vol.52 (5), p.1388-1392

2023

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The metalation of hen egg white lysozyme impacts protein stability as shown by ion mobility mass spectrometry, differential scanning calorimetry, and X-ray crystallography

Chemical communications (Cambridge, England), 2017, Vol.53 (30), p.4246-4249

2017

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Monodentately-coordinated bioactive moieties in multimodal half-sandwich organoruthenium anticancer agents

Coordination chemistry reviews, 2021-07, Vol.439, p.213890, Article 213890

2021

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Challenges and Opportunities in the Development of Organometallic Anticancer Drugs

Organometallics, 2012-08, Vol.31 (16), p.5677-5685

2012

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Structure-activity relationships for ruthenium and osmium anticancer agents - towards clinical development

Biodistribution of the novel anticancer drug sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] KP-1339/IT139 in nude BALB/c mice and implications on its mode of action

Bioorganometallic chemistry--from teaching paradigms to medicinal applications

Anticancer activity of metal complexes: involvement of redox processes

Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs

Polynuclear ruthenium, osmium and gold complexes. The quest for innovative anticancer chemotherapeutics

KP1019, A New Redox-Active Anticancer Agent - Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients

The development of RAPTA compounds for the treatment of tumors

An Organoruthenium Anticancer Agent Shows Unexpected Target Selectivity For Plectin

Antitumour metal compounds: more than theme and variations

From bench to bedside – preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1 H-indazole)ruthenate(III)] (KP1019 or FFC14A)

From Catalysis to Cancer: Toward Structure–Activity Relationships for Benzimidazol-2-ylidene-Derived N‑Heterocyclic-Carbene Complexes as Anticancer Agents

Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action

Unexpected arene ligand exchange results in the oxidation of an organoruthenium anticancer agent: the first X-ray structure of a protein-Ru(carbene) adduct

Emerging Protein Targets for Anticancer Metallodrugs: Inhibition of Thioredoxin Reductase and Cathepsin B by Antitumor Ruthenium(II)−Arene Compounds

A Combined Spectroscopic and Protein Crystallography Study Reveals Protein Interactions of RhI(NHC) Complexes at the Molecular Level

The ruthenium(II)–arene compound RAPTA-C induces apoptosis in EAC cells through mitochondrial and p53–JNK pathways

Anticancer metallodrugs: where is the next cisplatin?

Characterization of the binding sites of the anticancer ruthenium(III) complexes KP1019 and KP1339 on human serum albumin via competition studies

Impact of the Metal Center and Leaving Group on the Anticancer Activity of Organometallic Complexes of Pyridine-2-carbothioamide

Making organoruthenium complexes of 8-hydroxyquinolines more hydrophilic: impact of a novel l-phenylalanine-derived arene ligand on the biological activity

Platinum(terpyridine) complexes with N-heterocyclic carbene co-ligands: high antiproliferative activity and low toxicity in vivo

The metalation of hen egg white lysozyme impacts protein stability as shown by ion mobility mass spectrometry, differential scanning calorimetry, and X-ray crystallography

Monodentately-coordinated bioactive moieties in multimodal half-sandwich organoruthenium anticancer agents

Challenges and Opportunities in the Development of Organometallic Anticancer Drugs

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