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Target site occupancy: emerging generalizations from clinical and preclinical studies

Pharmacology & therapeutics (Oxford), 2009-06, Vol.122 (3), p.281-301

2009

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Presenilin-1 and -2 Are Molecular Targets for γ-Secretase Inhibitors

The Journal of biological chemistry, 2000-11, Vol.275 (44), p.34086-34091

2000

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Anxiolytic-like effects of the corticotropin-releasing factor1 (CRF1) antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] administered acutely or chronically at doses occupying central CRF1 receptors in rats

The Journal of pharmacology and experimental therapeutics, 2004-04, Vol.309 (1), p.293

2004

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Die Franzoesische Revolution im Urteil der Zeitgenossen und der Nachwelt

1983

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Imidazo[4,5- b]pyridines as corticotropin releasing factor receptor ligands

Bioorganic & medicinal chemistry letters, 2003-01, Vol.13 (1), p.125-128

2003

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Attenuation of fear conditioning by antisense inhibition of brain corticotropin releasing factor-2 receptor

Brain research. Molecular brain research., 2001-04, Vol.89 (1), p.29-40

2001

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Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine

Molecular pharmacology, 2000-01, Vol.57 (1), p.75

2000

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Imidazo[4,5- c]pyridines as corticotropin releasing factor receptor ligands

Bioorganic & medicinal chemistry letters, 2003-01, Vol.13 (1), p.129-131

2003

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Synthesis and Structure−Activity Relationships of 8-(Pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: Potent, Orally Bioavailable Corticotropin Releasing Factor Receptor-1 (CRF1) Antagonists

Journal of medicinal chemistry, 2009-05, Vol.52 (9), p.3084-3092

2009

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Alignment of receptor nomenclature with the human genome: classification of 5-HT1B and 5-HT1D receptor subtypes

Trends in pharmacological sciences (Regular ed.), 1996-03, Vol.17 (3), p.103-105

1996

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Serotonin 5‐HT2C Receptor Stimulates Cyclic GMP Formation in Choroid Plexus

Journal of neurochemistry, 1995-01, Vol.64 (1), p.199-205

1995

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Messenger RNA Editing of the Human Serotonin 5-HT2C Receptor

Neuropsychopharmacology (New York, N.Y.), 1999-08, Vol.21 (2), p.82S-90S

1999

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8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: Selective and Centrally Active Corticotropin-Releasing Factor Receptor-1 (CRF1) Antagonists

Journal of medicinal chemistry, 2009-05, Vol.52 (9), p.3073-3083

2009

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Molecular heterogeneity of the gamma-aminobutyric acid (GABA) transport system. Cloning of two novel high affinity GABA transporters from rat brain

The Journal of biological chemistry, 1992-10, Vol.267 (29), p.21098-21104

1992

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Cloning and expression of a glycine transporter reveal colocalization with NMDA receptors

Neuron (Cambridge, Mass.), 1992-05, Vol.8 (5), p.927-935

1992

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4-(1,3-Dimethoxyprop-2-ylamino)-2,7-dimethyl-8-(2,4-dichlorophenyl)pyrazolo[1,5-a]-1,3,5-triazine: A Potent, Orally Bioavailable CRF1 Receptor Antagonist

Journal of medicinal chemistry, 2000-02, Vol.43 (3), p.449-456

2000

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The 5‐HT4 receptor: molecular cloning and pharmacological characterization of two splice variants

The EMBO journal, 1995-06, Vol.14 (12), p.2806-2815

1995

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The α1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human α1c subtype

Molecular pharmacology, 1994, Vol.45 (4), p.703-708

1994

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Molecular biology of 5-HT receptors

Trends in Pharmacological Sciences, 1989-02, Vol.10 (2), p.64-69

Hartig, Paul R.

1989

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Cloning and expression of a high affinity taurine transporter from rat brain

Molecular pharmacology, 1992-10, Vol.42 (4), p.563-569

1992

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Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase

Proceedings of the National Academy of Sciences - PNAS, 1993-01, Vol.90 (2), p.408-412

1993

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A subfamily of 5-HT1D receptor genes

Trends in pharmacological sciences (Regular ed.), 1992-04, Vol.13 (4), p.152-159

1992

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Possible Role of Valvular Serotonin 5-HT2B Receptors in the Cardiopathy Associated with Fenfluramine

Molecular pharmacology, 2000-01, Vol.57 (1), p.75

2000

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Human Serotonin 1D Receptor is Encoded by a Subfamily of Two Distinct Genes: 5-HT1Dαand 5-HT1Dβ

Proceedings of the National Academy of Sciences - PNAS, 1992-04, Vol.89 (8), p.3630-3634

1992

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The discovery of 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1 ,5-a]-pyrimidine: a corticotropin-releasing factor (hCRF1) antagonist

Bioorganic & medicinal chemistry, 2000-01, Vol.8 (1), p.181-189

2000

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Target site occupancy: emerging generalizations from clinical and preclinical studies

Presenilin-1 and -2 Are Molecular Targets for γ-Secretase Inhibitors

Anxiolytic-like effects of the corticotropin-releasing factor1 (CRF1) antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] administered acutely or chronically at doses occupying central CRF1 receptors in rats

Die Franzoesische Revolution im Urteil der Zeitgenossen und der Nachwelt

Imidazo[4,5- b]pyridines as corticotropin releasing factor receptor ligands

Attenuation of fear conditioning by antisense inhibition of brain corticotropin releasing factor-2 receptor

Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine

Imidazo[4,5- c]pyridines as corticotropin releasing factor receptor ligands

Synthesis and Structure−Activity Relationships of 8-(Pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: Potent, Orally Bioavailable Corticotropin Releasing Factor Receptor-1 (CRF1) Antagonists

Alignment of receptor nomenclature with the human genome: classification of 5-HT1B and 5-HT1D receptor subtypes

Serotonin 5‐HT2C Receptor Stimulates Cyclic GMP Formation in Choroid Plexus

Messenger RNA Editing of the Human Serotonin 5-HT2C Receptor

8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: Selective and Centrally Active Corticotropin-Releasing Factor Receptor-1 (CRF1) Antagonists

Molecular heterogeneity of the gamma-aminobutyric acid (GABA) transport system. Cloning of two novel high affinity GABA transporters from rat brain

Cloning and expression of a glycine transporter reveal colocalization with NMDA receptors

4-(1,3-Dimethoxyprop-2-ylamino)-2,7-dimethyl-8-(2,4-dichlorophenyl)pyrazolo[1,5-a]-1,3,5-triazine: A Potent, Orally Bioavailable CRF1 Receptor Antagonist

The 5‐HT4 receptor: molecular cloning and pharmacological characterization of two splice variants

The α1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human α1c subtype

Molecular biology of 5-HT receptors

Cloning and expression of a high affinity taurine transporter from rat brain

Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase

A subfamily of 5-HT1D receptor genes

Possible Role of Valvular Serotonin 5-HT2B Receptors in the Cardiopathy Associated with Fenfluramine

Human Serotonin 1D Receptor is Encoded by a Subfamily of Two Distinct Genes: 5-HT1Dαand 5-HT1Dβ

The discovery of 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1 ,5-a]-pyrimidine: a corticotropin-releasing factor (hCRF1) antagonist

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