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PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis

Science (American Association for the Advancement of Science), 2020-03, Vol.367 (6482), p.1147-1151

2020

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A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N‑Myristoyltransferase Inhibitors

Journal of medicinal chemistry, 2018-09, Vol.61 (18), p.8374-8389

2018

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Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease

Journal of medicinal chemistry, 2020-03, Vol.63 (6), p.3066-3089

2020

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Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis

Journal of medicinal chemistry, 2022-04, Vol.65 (7), p.5606-5624

2022

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Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma brucei N‑Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis

Journal of medicinal chemistry, 2014-12, Vol.57 (23), p.9855-9869

2014

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Synthesis of sparteine-like chiral diamines and evaluation in the enantioselective lithiation-substitution of N-(tert-butoxycarbonyl)pyrrolidine

Organic & biomolecular chemistry, 2003-11, Vol.1 (22), p.3977-3988

2003

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Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

Journal of medicinal chemistry, 2012-01, Vol.55 (1), p.140-152

2012

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N‑Myristoyltransferase Is a Cell Wall Target in Aspergillus fumigatus

ACS chemical biology, 2015-06, Vol.10 (6), p.1425-1434

2015

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Chemical Validation of Trypanothione Synthetase: A POTENTIAL DRUG TARGET FOR HUMAN TRYPANOSOMIASIS

The Journal of biological chemistry, 2009-12, Vol.284 (52), p.36137-36145

2009

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Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors

ChemMedChem, 2012-01, Vol.7 (1), p.95-106

2012

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Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma bruceiN-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis

Journal of medicinal chemistry, 2014-11, Vol.57 (23), p.9855-9869

2014

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A Concise Synthesis of the Octalactins

Journal of the American Chemical Society, 2004-02, Vol.126 (7), p.2194-2207

2004

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Indium metal as a reducing agent in organic synthesis

Perkin 1 : an international journal of organic and bio-organic chemistry, 2001 (9), p.955-977

2001

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Chemical Validation of Trypanothione Synthetase

The Journal of biological chemistry, 2009-12, Vol.284 (52), p.36137-36145

2009

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Synthesis of medium-ring lactones via tandem methylenation/Claisen rearrangement of cyclic carbonates

Tetrahedron, 2002-03, Vol.58 (10), p.1943-1971

2002

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The role of phthiocerol dimycoserosate and the PE/PPE protein family in outer cell wall permeability in Mycobacterium tuberculosis

Science (American Association for the Advancement of Science), 2020-03, Vol.367 (6482), p.1147-1151

2020

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Evaluation of a sparteine-like diamine for asymmetric synthesis

Chemical communications (Cambridge, England), 2001-01 (13), p.1202-1203

2001

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Enantioselective Synthesis of Alkyl-substituted Eight-membered Lactones by Claisen Rearrangement

Synlett, 1999-01, Vol.1999 (Sup. 1), p.972-974

1999

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The Horner–Wadsworth–Emmons reaction in the synthesis of macrocyclic peptides: the Trp-His-Gly-Arg derived macrocycle of moroidin

Tetrahedron letters, 2003-07, Vol.44 (28), p.5189-5191

2003

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Bispidine-derived N-acyliminium ions in synthesis: stereocontrolled construction of the BCD rings of sparteine

Tetrahedron letters, 2000-08, Vol.41 (32), p.6167-6170

2000

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Diastereoselective synthesis of sparteine analogues via lithiation–electrophilic quench of N-Boc bispidines

Tetrahedron letters, 2000-08, Vol.41 (32), p.6161-6165

2000

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ASYMMETRIC SYNTHESIS OF N-SUBSTITUTED (R)-2-[(PYRROLIDIN-1-YL)METHYL]PYRROLIDINES

Synthetic communications, 2001-01, Vol.31 (8), p.1155-1160

2001

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Indium as a Reducing Agent: Reduction of Oximes

Synlett, 2000, Vol.2000 (11), p.1601-1602

2000

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Synthesis of medium-ring lactones via tandem methylenation/Claisen rearrangement of cyclic carbonates

Chemical communications (Cambridge, England), 2000-01 (7), p.629-630

2000

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PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N‑Myristoyltransferase Inhibitors

Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease

Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis

Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma brucei N‑Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis

Synthesis of sparteine-like chiral diamines and evaluation in the enantioselective lithiation-substitution of N-(tert-butoxycarbonyl)pyrrolidine

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

N‑Myristoyltransferase Is a Cell Wall Target in Aspergillus fumigatus

Chemical Validation of Trypanothione Synthetase: A POTENTIAL DRUG TARGET FOR HUMAN TRYPANOSOMIASIS

2‑Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure–Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization

Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors

Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma bruceiN-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis

A Concise Synthesis of the Octalactins

Indium metal as a reducing agent in organic synthesis

Chemical Validation of Trypanothione Synthetase

Synthesis of medium-ring lactones via tandem methylenation/Claisen rearrangement of cyclic carbonates

The role of phthiocerol dimycoserosate and the PE/PPE protein family in outer cell wall permeability in Mycobacterium tuberculosis

Evaluation of a sparteine-like diamine for asymmetric synthesis

Enantioselective Synthesis of Alkyl-substituted Eight-membered Lactones by Claisen Rearrangement

The Horner–Wadsworth–Emmons reaction in the synthesis of macrocyclic peptides: the Trp-His-Gly-Arg derived macrocycle of moroidin

Bispidine-derived N-acyliminium ions in synthesis: stereocontrolled construction of the BCD rings of sparteine

Diastereoselective synthesis of sparteine analogues via lithiation–electrophilic quench of N-Boc bispidines

ASYMMETRIC SYNTHESIS OF N-SUBSTITUTED (R)-2-[(PYRROLIDIN-1-YL)METHYL]PYRROLIDINES

Indium as a Reducing Agent: Reduction of Oximes

Synthesis of medium-ring lactones via tandem methylenation/Claisen rearrangement of cyclic carbonates

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