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Herpes Simplex Virus Suppresses Necroptosis in Human Cells

Cell host & microbe, 2015-02, Vol.17 (2), p.243-251

2015

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Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium

The Journal of experimental medicine, 2017-12, Vol.214 (12), p.3687-3705

2017

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Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice

The Journal of immunology (1950), 2014-06, Vol.192 (12), p.5476-5480

2014

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Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death

Proceedings of the National Academy of Sciences - PNAS, 2018-09, Vol.115 (39), p.E9192-E9200

2018

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Discovery of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor

Journal of medicinal chemistry, 2008-08, Vol.51 (15), p.4632-4640

2008

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Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer

ACS medicinal chemistry letters, 2019-06, Vol.10 (6), p.857-862

2019

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Randomized clinical study of safety, pharmacokinetics, and pharmacodynamics of RIPK1 inhibitor GSK2982772 in healthy volunteers

Pharmacology research & perspectives, 2017-12, Vol.5 (6), p.n/a

2017

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Antioxidant Activity of 3-[N-(Acylhydrazono)ethyl]-4-hydroxy-coumarins

Molecules (Basel, Switzerland), 2016-01, Vol.21 (2), p.138-138

2016

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Inhibitors of RIP1 kinase: a patent review (2016-present)

Expert opinion on therapeutic patents, 2021-02, Vol.31 (2), p.137-151

Harris, Philip A.

2021

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Recent progress on MAP kinase pathway inhibitors

Bioorganic & medicinal chemistry letters, 2015-10, Vol.25 (19), p.4047-4056

2015

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Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

Journal of medicinal chemistry, 2017-02, Vol.60 (4), p.1247-1261

2017

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Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles

Bioorganic & medicinal chemistry letters, 2004-02, Vol.14 (4), p.953-957

2004

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RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation

Molecular cell, 2019-02, Vol.73 (3), p.413-428.e7

2019

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Discovery of Novel Benzimidazoles as Potent Inhibitors of TIE-2 and VEGFR-2 Tyrosine Kinase Receptors

Journal of medicinal chemistry, 2007-09, Vol.50 (18), p.4453-4470

2007

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Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis

ACS medicinal chemistry letters, 2013-12, Vol.4 (12), p.1238-1243

2013

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RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB Activation

Cellular and molecular gastroenterology and hepatology, 2020-01, Vol.9 (2), p.295-312

2020

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High throughput screening identifies ATP-competitive inhibitors of the NLRP1 inflammasome

Bioorganic & medicinal chemistry letters, 2015-07, Vol.25 (14), p.2739-2743

2015

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Transformation of a hydroxyl into an acyl group on α-pyrone ring: a novel route to 3,4-diacylcoumarins

Tetrahedron, 2012-01, Vol.68 (2), p.761-766

2012

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Discovery and Evaluation of 2-Anilino-5-aryloxazoles as a Novel Class of VEGFR2 Kinase Inhibitors

Journal of medicinal chemistry, 2005-03, Vol.48 (5), p.1610-1619

2005

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The identification of pyrazolo[1,5- a]pyridines as potent p38 kinase inhibitors

Bioorganic & medicinal chemistry, 2008-10, Vol.18 (20), p.5428-5430

2008

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Pyrazolo[1,5-a]pyridines as p38 Kinase Inhibitors

Organic letters, 2005-10, Vol.7 (21), p.4753-4756

2005

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Correction: Kotali, A. et al. 7-Hydroxy-8-acetylcoumarin N-1-(Carboxymethyl)pyridinium Chloride Hydrazone. Molbank 2008, M571

MolBank, 2009-03, Vol.2009 (1), p.M593

2009

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Herpes Simplex Virus Suppresses Necroptosis in Human Cells

Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium

Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice

Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death

Discovery of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor

Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer

Randomized clinical study of safety, pharmacokinetics, and pharmacodynamics of RIPK1 inhibitor GSK2982772 in healthy volunteers

Antioxidant Activity of 3-[N-(Acylhydrazono)ethyl]-4-hydroxy-coumarins

Inhibitors of RIP1 kinase: a patent review (2016-present)

Recent progress on MAP kinase pathway inhibitors

RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors

Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation

RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer

Discovery of Novel Benzimidazoles as Potent Inhibitors of TIE-2 and VEGFR-2 Tyrosine Kinase Receptors

Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis

RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB Activation

High throughput screening identifies ATP-competitive inhibitors of the NLRP1 inflammasome

Transformation of a hydroxyl into an acyl group on α-pyrone ring: a novel route to 3,4-diacylcoumarins

Discovery and Evaluation of 2-Anilino-5-aryloxazoles as a Novel Class of VEGFR2 Kinase Inhibitors

The identification of pyrazolo[1,5- a]pyridines as potent p38 kinase inhibitors

Pyrazolo[1,5-a]pyridines as p38 Kinase Inhibitors

Correction: Kotali, A. et al. 7-Hydroxy-8-acetylcoumarin N-1-(Carboxymethyl)pyridinium Chloride Hydrazone. Molbank 2008, M571

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