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Replication stress induces 53BP1-containing OPT domains in G1 cells

The Journal of cell biology, 2011-04, Vol.193 (1), p.97-108

2011

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Deubiquitylating enzymes and drug discovery: emerging opportunities

Nature reviews. Drug discovery, 2018-01, Vol.17 (1), p.57-78

2018

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The Human Werner Syndrome Protein Stimulates Repair of Oxidative DNA Base Damage by the DNA Glycosylase NEIL1

The Journal of biological chemistry, 2007-09, Vol.282 (36), p.26591-26602

2007

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Cooperation of the Cockayne Syndrome Group B Protein and Poly(ADP-Ribose) Polymerase 1 in the Response to Oxidative Stress

Molecular and Cellular Biology, 2005-09, Vol.25 (17), p.7625-7636

2005

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Central Role for the Werner Syndrome Protein/Poly(ADP-Ribose) Polymerase 1 Complex in the Poly(ADP-Ribosyl)ation Pathway after DNA Damage

Molecular and Cellular Biology, 2003-12, Vol.23 (23), p.8601-8613

2003

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Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity

Journal of the American Chemical Society, 2020-07, Vol.142 (28), p.12020-12026

2020

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Regulation of WRN Helicase Activity in Human Base Excision Repair

The Journal of biological chemistry, 2004-12, Vol.279 (51), p.53465-53474

2004

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Tissue specific induction of cytochrome P450 (CYP) 1A1 and 1B1 in rat liver and lung following in vitro (tissue slice) and in vivo exposure to benzo( a)pyrene

Toxicology in vitro, 2006-06, Vol.20 (4), p.426-438

2006

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Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells

ACS chemical biology, 2016-12, Vol.11 (12), p.3268-3272

2016

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Activity-based protein profiling reveals deubiquitinase and aldehyde dehydrogenase targets of a cyanopyrrolidine probe

RSC medicinal chemistry, 2021-11, Vol.12 (11), p.1935-1943

2021

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Metal-catalyzed Oxidation of the Werner Syndrome Protein Causes Loss of Catalytic Activities and Impaired Protein-Protein Interactions

The Journal of biological chemistry, 2007-12, Vol.282 (50), p.36403-36411

2007

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Correction to “Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity”

Journal of the American Chemical Society, 2020-09, Vol.142 (35), p.15199-15199

2020

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WRN exonuclease activity is blocked by DNA termini harboring 3′ obstructive groups

Mechanisms of ageing and development, 2007-03, Vol.128 (3), p.259-266

2007

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The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta

Nucleic acids research, 2006-01, Vol.34 (2), p.745

2006

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Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process

Carcinogenesis (New York), 2003-05, Vol.24 (5), p.791-802

2003

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Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein

Nucleic acids research, 2004-01, Vol.32 (13), p.4003-4014

2004

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The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity

The Journal of biological chemistry, 2003-06, Vol.278 (25), p.22686-22695

2003

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DNA Adduct Formation in Precision-Cut Rat Liver and Lung Slices Exposed to Benzo[a]pyrene

Toxicological sciences, 2004-02, Vol.77 (2), p.307-314

2004

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WRN Exonuclease activity is blocked by specific oxidatively induced base lesions positioned in either DNA strand

Nucleic acids research, 2008-09, Vol.36 (15), p.4975-4987

2008

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Werner protein stimulates topoisomerase I DNA relaxation activity

Cancer research (Chicago, Ill.), 2003-11, Vol.63 (21), p.7136-7146

2003

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Werner syndrome protein 1367 variants and disposition towards coronary artery disease in Caucasian patients

Mechanisms of ageing and development, 2004-07, Vol.125 (7), p.491-496

2004

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The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase

Nucleic acids research, 2006-02, Vol.34 (2), p.745-754

Harrigan, J. A.

2006

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The Werner Syndrome Protein Stimulates DNA Polymerase Î² Strand Displacement Synthesis via Its Helicase Activity

The Journal of biological chemistry, 2003-06, Vol.278 (25), p.22686

2003

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Monitoring Target Engagement of Deubiquitylating Enzymes Using Activity Probes: Past, Present, and Future

Methods in molecular biology (Clifton, N.J.), 2016-01, Vol.1449, p.395

2016

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Telomere-binding Protein TRF2 Binds to and Stimulates the Werner and Bloom Syndrome Helicases

The Journal of biological chemistry, 2002-10, Vol.277 (43), p.41110-41119

2002

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Replication stress induces 53BP1-containing OPT domains in G1 cells

Deubiquitylating enzymes and drug discovery: emerging opportunities

The Human Werner Syndrome Protein Stimulates Repair of Oxidative DNA Base Damage by the DNA Glycosylase NEIL1

Cooperation of the Cockayne Syndrome Group B Protein and Poly(ADP-Ribose) Polymerase 1 in the Response to Oxidative Stress

Central Role for the Werner Syndrome Protein/Poly(ADP-Ribose) Polymerase 1 Complex in the Poly(ADP-Ribosyl)ation Pathway after DNA Damage

Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity

Regulation of WRN Helicase Activity in Human Base Excision Repair

Tissue specific induction of cytochrome P450 (CYP) 1A1 and 1B1 in rat liver and lung following in vitro (tissue slice) and in vivo exposure to benzo( a)pyrene

Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells

Activity-based protein profiling reveals deubiquitinase and aldehyde dehydrogenase targets of a cyanopyrrolidine probe

Metal-catalyzed Oxidation of the Werner Syndrome Protein Causes Loss of Catalytic Activities and Impaired Protein-Protein Interactions

Correction to “Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity”

WRN exonuclease activity is blocked by DNA termini harboring 3′ obstructive groups

The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta

Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process

Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein

The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity

DNA Adduct Formation in Precision-Cut Rat Liver and Lung Slices Exposed to Benzo[a]pyrene

WRN Exonuclease activity is blocked by specific oxidatively induced base lesions positioned in either DNA strand

Werner protein stimulates topoisomerase I DNA relaxation activity

Werner syndrome protein 1367 variants and disposition towards coronary artery disease in Caucasian patients

The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase

The Werner Syndrome Protein Stimulates DNA Polymerase Î² Strand Displacement Synthesis via Its Helicase Activity

Monitoring Target Engagement of Deubiquitylating Enzymes Using Activity Probes: Past, Present, and Future

Telomere-binding Protein TRF2 Binds to and Stimulates the Werner and Bloom Syndrome Helicases

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