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Molecular Basis for Cyclooxygenase Inhibition by the Non-steroidal Anti-inflammatory Drug Naproxen

The Journal of biological chemistry, 2010-11, Vol.285 (45), p.34950-34959

2010

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Base excision repair of the N-(2-deoxy-d-erythro-pentofuranosyl)-urea lesion by the hNEIL1 glycosylase

Nucleic acids research, 2023-05, Vol.51 (8), p.3754-3769

2023

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Computational redesign of a fluorogen activating protein with Rosetta

PLoS computational biology, 2021-11, Vol.17 (11), p.e1009555-e1009555

2021

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Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity

Nucleic acids research, 2018-09, Vol.46 (16), p.8090-8104

2018

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Synthesis and Structure–Activity Relationships of 5,6,7-Substituted Pyrazolopyrimidines: Discovery of a Novel TSPO PET Ligand for Cancer Imaging

Journal of medicinal chemistry, 2013-04, Vol.56 (8), p.3429-3433

2013

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Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR

Molecular cell, 2003-04, Vol.11 (4), p.1093-1100

2003

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Cryo‐neutron crystallographic data collection and preliminary refinement of left‐handed Z‐DNA d(CGCGCG)

Acta crystallographica. Section F, Structural biology communications, 2018-10, Vol.74 (10), p.603-609

2018

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Water structure around a left-handed Z-DNA fragment analyzed by cryo neutron crystallography

Nucleic acids research, 2021-05, Vol.49 (8), p.4782-4792

2021

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Methylation of Histone H3 by Coactivator-Associated Arginine Methyltransferase 1

Biochemistry (Easton), 2001-05, Vol.40 (19), p.5747-5756

2001

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Synthesis and Biophysical Properties of Phosphorodiamidate Piperidino Oligomers

Organic letters, 2023-02, Vol.25 (6), p.901-906

2023

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Cryo neutron crystallography demonstrates influence of RNA 2′-OH orientation on conformation, sugar pucker and water structure

Nucleic acids research, 2022-07, Vol.50 (13), p.7721-7738

2022

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Phosphorus SAD Phasing for Nucleic Acid Structures: Limitations and Potential

Crystals (Basel), 2016-10, Vol.6 (10), p.125-125

2016

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RNAs Containing Carbocyclic Ribonucleotides

Organic letters, 2022-01, Vol.24 (2), p.525-530

2022

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Analysis of the Structure and Function of YfcG from Escherichia coli Reveals an Efficient and Unique Disulfide Bond Reductase

Biochemistry (Easton), 2009-07, Vol.48 (28), p.6559-6561

2009

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Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase η in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2′-deoxyguanosine

The Journal of biological chemistry, 2015-06, Vol.290 (26), p.15921-15933

2015

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Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs

Nucleic acids research, 2021-11, Vol.49 (19), p.10851-10867

2021

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Shorter Is Better: The α‑(l)‑Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs

Journal of the American Chemical Society, 2023-09, Vol.145 (36), p.19691-19706

2023

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Incorporating a Thiophosphate Modification into a Common RNA Tetraloop Motif Causes an Unanticipated Stability Boost

Biochemistry (Easton), 2020-12, Vol.59 (49), p.4627-4637

2020

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Synthesis and characterization of chiral 6-azaspiro[2.5]octanes as potent and selective antagonists of the M4 muscarinic acetylcholine receptor

Bioorganic & medicinal chemistry letters, 2022-01, Vol.56, p.128479-128479, Article 128479

2022

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Structure and Stability of Ago2 MID‐Nucleotide Complexes: All‐in‐One (Drop) His6‐SUMO Tag Removal, Nucleotide Binding, and Crystal Growth

Current protocols, 2024-06, Vol.4 (6), p.e1088-n/a

2024

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Crystal Structures of Trypanosoma brucei Sterol 14α-Demethylase and Implications for Selective Treatment of Human Infections

The Journal of biological chemistry, 2010-01, Vol.285 (3), p.1773-1780

2010

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A Novel M 1 PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity

ACS chemical neuroscience, 2018-09, Vol.9 (9), p.2274-2285

2018

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Discovery, characterization and biological evaluation of a novel (R)-4,4-difluoropiperidine scaffold as dopamine receptor 4 (D4R) antagonists

Bioorganic & medicinal chemistry letters, 2016-12, Vol.26 (23), p.5757-5764

2016

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Total Synthesis of Stemaphylline N-Oxide and Related C9a-Epimeric Analogues

Chemistry : a European journal, 2013-09, Vol.19 (36), p.11847-11852

2013

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Discovery of VU6005649, a CNS Penetrant mGlu7/8 Receptor PAM Derived from a Series of Pyrazolo[1,5‑a]pyrimidines

ACS medicinal chemistry letters, 2017-10, Vol.8 (10), p.1110-1115

2017

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Molecular Basis for Cyclooxygenase Inhibition by the Non-steroidal Anti-inflammatory Drug Naproxen

Base excision repair of the N-(2-deoxy-d-erythro-pentofuranosyl)-urea lesion by the hNEIL1 glycosylase

Computational redesign of a fluorogen activating protein with Rosetta

Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity

Synthesis and Structure–Activity Relationships of 5,6,7-Substituted Pyrazolopyrimidines: Discovery of a Novel TSPO PET Ligand for Cancer Imaging

Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR

Cryo‐neutron crystallographic data collection and preliminary refinement of left‐handed Z‐DNA d(CGCGCG)

Water structure around a left-handed Z-DNA fragment analyzed by cryo neutron crystallography

Methylation of Histone H3 by Coactivator-Associated Arginine Methyltransferase 1

Synthesis and Biophysical Properties of Phosphorodiamidate Piperidino Oligomers

Cryo neutron crystallography demonstrates influence of RNA 2′-OH orientation on conformation, sugar pucker and water structure

Phosphorus SAD Phasing for Nucleic Acid Structures: Limitations and Potential

RNAs Containing Carbocyclic Ribonucleotides

Analysis of the Structure and Function of YfcG from Escherichia coli Reveals an Efficient and Unique Disulfide Bond Reductase

Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase η in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2′-deoxyguanosine

Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs

Shorter Is Better: The α‑(l)‑Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs

Incorporating a Thiophosphate Modification into a Common RNA Tetraloop Motif Causes an Unanticipated Stability Boost

Synthesis and characterization of chiral 6-azaspiro[2.5]octanes as potent and selective antagonists of the M4 muscarinic acetylcholine receptor

Structure and Stability of Ago2 MID‐Nucleotide Complexes: All‐in‐One (Drop) His6‐SUMO Tag Removal, Nucleotide Binding, and Crystal Growth

Crystal Structures of Trypanosoma brucei Sterol 14α-Demethylase and Implications for Selective Treatment of Human Infections

A Novel M 1 PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity

Discovery, characterization and biological evaluation of a novel (R)-4,4-difluoropiperidine scaffold as dopamine receptor 4 (D4R) antagonists

Total Synthesis of Stemaphylline N-Oxide and Related C9a-Epimeric Analogues

Discovery of VU6005649, a CNS Penetrant mGlu7/8 Receptor PAM Derived from a Series of Pyrazolo[1,5‑a]pyrimidines

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