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Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A

Nature communications, 2023-10, Vol.14 (1), p.6382-13, Article 6382

2023

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Synthesis of 1,4-azaphosphinine nucleosides and evaluation as inhibitors of human cytidine deaminase and APOBEC3A

Beilstein journal of organic chemistry, 2024-05, Vol.20 (1), p.1088-1098

2024

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Impact of H216 on the DNA Binding and Catalytic Activities of the HIV Restriction Factor APOBEC3G

Journal of Virology, 2013-06, Vol.87 (12), p.7008-7014

2013

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Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G

Nature, 2008-03, Vol.452 (7183), p.116-119

2008

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Small-Angle X-ray Scattering (SAXS) Measurements of APOBEC3G Provide Structural Basis for Binding of Single-Stranded DNA and Processivity

Viruses, 2022-09, Vol.14 (9), p.1974

2022

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An Extended Structure of the APOBEC3G Catalytic Domain Suggests a Unique Holoenzyme Model

Journal of molecular biology, 2009-06, Vol.389 (5), p.819-832

2009

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Crystal Structure of the APOBEC3G Catalytic Domain Reveals Potential Oligomerization Interfaces

Structure (London), 2010-01, Vol.18 (1), p.28-38

2010

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Small-Angle X-ray Scattering Models of APOBEC3B Catalytic Domain in a Complex with a Single-Stranded DNA Inhibitor

Viruses, 2021-02, Vol.13 (2), p.290

2021

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A Single Amino Acid in Human APOBEC3F Alters Susceptibility to HIV-1 Vif

The Journal of biological chemistry, 2010-12, Vol.285 (52), p.40785-40792

2010

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GTP-Ras Disrupts the Intramolecular Complex of C1 and RA Domains of Nore1

Structure (London), 2006-05, Vol.14 (5), p.881-888

2006

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Identification of a Single Amino Acid Required for APOBEC3 Antiretroviral Cytidine Deaminase Activity

Journal of Virology, 2011-06, Vol.85 (11), p.5691-5695

2011

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Abstract 1224 Interaction of the cancer DNA cytosine deaminase APOBEC3B with nucleic acid structures

The Journal of biological chemistry, 2024-03, Vol.300 (3), p.106152, Article 106152

2024

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Design, Synthesis, and Evaluation of a Cross-Linked Oligonucleotide as the First Nanomolar Inhibitor of APOBEC3A

Biochemistry (Easton), 2022-11, Vol.61 (22), p.2568-2578

2022

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Selective inhibition of APOBEC3 enzymes by single-stranded DNAs containing 2′-deoxyzebularine

Organic & biomolecular chemistry, 2019-11, Vol.17 (43), p.9435-9441

2019

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A Comparison of Two Single-Stranded DNA Binding Models by Mutational Analysis of APOBEC3G

Biology (Basel, Switzerland), 2012-08, Vol.1 (2), p.260-276

2012

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Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2′-Deoxyzebularine Analogues

Biochemistry (Easton), 2019-02, Vol.58 (5), p.391-400

2019

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Seven-membered ring nucleobases as inhibitors of human cytidine deaminase and APOBEC3A

Organic & biomolecular chemistry, 2023-06, Vol.21 (24), p.5117-5128

2023

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Experimentally based structural model of Yih1 provides insight into its function in controlling the key translational regulator Gcn2

FEBS letters, 2021-02, Vol.595 (3), p.324-340

2021

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Differential Inhibition of APOBEC3 DNA‐Mutator Isozymes by Fluoro‐ and Non‐Fluoro‐Substituted 2′‐Deoxyzebularine Embedded in Single‐Stranded DNA

Chembiochem : a European journal of chemical biology, 2020-04, Vol.21 (7), p.1028-1035

2020

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Tyrocidine A Analogues Bearing the Planar d‑Phe-2-Abz Turn Motif: How Conformation Impacts Bioactivity

Journal of medicinal chemistry, 2017-12, Vol.60 (23), p.9565-9574

2017

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NMR-based method of small changes reveals how DNA mutator APOBEC3A interacts with its single-stranded DNA substrate

Nucleic acids research, 2017-05, Vol.45 (9), p.5602-5613

2017

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NMR Shows Why a Small Chemical Change Almost Abolishes the Antimicrobial Activity of Glycocin F

Biochemistry (Easton), 2023-09, Vol.62 (17), p.2669-2676

2023

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Crystal and NMR Structures of a Peptidomimetic β‐Turn That Provides Facile Synthesis of 13‐Membered Cyclic Tetrapeptides

Chemistry, an Asian journal, 2017-12, Vol.12 (24), p.3195-3202

2017

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Crystal and NMR Structures of a Peptidomimetic [beta]-Turn That Provides Facile Synthesis of 13-Membered Cyclic Tetrapeptides

Chemistry, an Asian journal, 2017-12, Vol.12 (24), p.3195

2017

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Cyclic peptides bearing the d‐Phe‐2‐Abz turn motif: Structural characterization and antimicrobial potential

Journal of peptide science, 2021-02, Vol.27 (2), p.e3291-n/a

2021

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Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A

Synthesis of 1,4-azaphosphinine nucleosides and evaluation as inhibitors of human cytidine deaminase and APOBEC3A

Impact of H216 on the DNA Binding and Catalytic Activities of the HIV Restriction Factor APOBEC3G

Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G

Small-Angle X-ray Scattering (SAXS) Measurements of APOBEC3G Provide Structural Basis for Binding of Single-Stranded DNA and Processivity

An Extended Structure of the APOBEC3G Catalytic Domain Suggests a Unique Holoenzyme Model

Crystal Structure of the APOBEC3G Catalytic Domain Reveals Potential Oligomerization Interfaces

Small-Angle X-ray Scattering Models of APOBEC3B Catalytic Domain in a Complex with a Single-Stranded DNA Inhibitor

A Single Amino Acid in Human APOBEC3F Alters Susceptibility to HIV-1 Vif

GTP-Ras Disrupts the Intramolecular Complex of C1 and RA Domains of Nore1

Identification of a Single Amino Acid Required for APOBEC3 Antiretroviral Cytidine Deaminase Activity

Abstract 1224 Interaction of the cancer DNA cytosine deaminase APOBEC3B with nucleic acid structures

Design, Synthesis, and Evaluation of a Cross-Linked Oligonucleotide as the First Nanomolar Inhibitor of APOBEC3A

Selective inhibition of APOBEC3 enzymes by single-stranded DNAs containing 2′-deoxyzebularine

A Comparison of Two Single-Stranded DNA Binding Models by Mutational Analysis of APOBEC3G

Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2′-Deoxyzebularine Analogues

Seven-membered ring nucleobases as inhibitors of human cytidine deaminase and APOBEC3A

Experimentally based structural model of Yih1 provides insight into its function in controlling the key translational regulator Gcn2

Differential Inhibition of APOBEC3 DNA‐Mutator Isozymes by Fluoro‐ and Non‐Fluoro‐Substituted 2′‐Deoxyzebularine Embedded in Single‐Stranded DNA

Tyrocidine A Analogues Bearing the Planar d‑Phe-2-Abz Turn Motif: How Conformation Impacts Bioactivity

NMR-based method of small changes reveals how DNA mutator APOBEC3A interacts with its single-stranded DNA substrate

NMR Shows Why a Small Chemical Change Almost Abolishes the Antimicrobial Activity of Glycocin F

Crystal and NMR Structures of a Peptidomimetic β‐Turn That Provides Facile Synthesis of 13‐Membered Cyclic Tetrapeptides

Crystal and NMR Structures of a Peptidomimetic [beta]-Turn That Provides Facile Synthesis of 13-Membered Cyclic Tetrapeptides

Cyclic peptides bearing the d‐Phe‐2‐Abz turn motif: Structural characterization and antimicrobial potential

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