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Mutations in Aspergillus fumigatus Resulting in Reduced Susceptibility to Posaconazole Appear To Be Restricted to a Single Amino Acid in the Cytochrome P450 14α-Demethylase

Antimicrobial Agents and Chemotherapy, 2003-02, Vol.47 (2), p.577-581

2003

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Posaconazole Is a Potent Inhibitor of Sterol 14α-Demethylation in Yeasts and Molds

Antimicrobial Agents and Chemotherapy, 2004-10, Vol.48 (10), p.3690-3696

2004

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Posaconazole Is Effective as Salvage Therapy in Zygomycosis: A Retrospective Summary of 91 Cases

Clinical infectious diseases, 2006-04, Vol.42 (7), p.e61-e65

2006

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Activity of posaconazole in the treatment of central nervous system fungal infections

Journal of antimicrobial chemotherapy, 2005-10, Vol.56 (4), p.745-755

2005

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Evernimicin Binds Exclusively to the 50S Ribosomal Subunit and Inhibits Translation in Cell-Free Systems Derived from both Gram-Positive and Gram-Negative Bacteria

Antimicrobial Agents and Chemotherapy, 2000-05, Vol.44 (5), p.1121-1126

2000

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Evernimicin (SCH27899) Inhibits a Novel Ribosome Target Site: Analysis of 23S Ribosomal DNA Mutants

Antimicrobial Agents and Chemotherapy, 2000-11, Vol.44 (11), p.3101-3106

2000

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Genetic Footprinting in Bacteria

Journal of Bacteriology, 2001-03, Vol.183 (5), p.1694-1706

2001

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Mutations in Ribosomal Protein L16 Conferring Reduced Susceptibility to Evernimicin (SCH27899): Implications for Mechanism of Action

Antimicrobial Agents and Chemotherapy, 2000-03, Vol.44 (3), p.732-738

2000

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Effects of Mutations in Ribosomal Protein L16 on Susceptibility and Accumulation of Evernimicin

Antimicrobial Agents and Chemotherapy, 2001-01, Vol.45 (1), p.79-83

2001

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Changes in susceptibility to posaconazole in clinical isolates of Candida albicans

Journal of antimicrobial chemotherapy, 2004-01, Vol.53 (1), p.74-80

2004

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Efficacy of SCH27899 in an Animal Model of Legionnaires' Disease Using Immunocompromised A/J Mice

Antimicrobial Agents and Chemotherapy, 2000-05, Vol.44 (5), p.1333-1336

2000

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Genomics and antimicrobial drug discovery

Antimicrobial agents and chemotherapy, 1999-03, Vol.43 (3), p.439-446

1999

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Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 ( 1), and the discovery of posaconazole [Sch 56592; 2 or ( S, S)- 5]

Bioorganic & medicinal chemistry letters, 2006, Vol.16 (1), p.186-190

2006

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The use of direct cDNA selection to rapidly and effectively identify genes in the fungus Aspergillus fumigatus

Fungal genetics and biology, 2002-06, Vol.36 (1), p.59-70

2002

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In Vitro and In Vivo Activities of SCH 56592 (Posaconazole), a New Triazole Antifungal Agent, againstAspergillus and Candida

Antimicrobial Agents and Chemotherapy, 2000-08, Vol.44 (8), p.2017-2022

2000

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In vitro and in vivo activities of SCH 56592 (Posaconazole), a new triazole antifungal agent, against Aspergillus and Candida

Antimicrobial agents and chemotherapy, 2000-08, Vol.44 (8), p.2017-2022

2000

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Sch 51048, a novel broad-spectrum orally active antifungal agent: Synthesis and preliminary structure-activity profile

Bioorganic & medicinal chemistry letters, 1995-01, Vol.5 (2), p.127-132

1995

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EmtA, a rRNA methyltransferase conferring high‐level evernimicin resistance

Molecular microbiology, 2001-09, Vol.41 (6), p.1349-1356

2001

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Posaconazole is a potent inhibitor of sterol 14alpha-demethylation in yeasts and molds

Antimicrobial agents and chemotherapy, 2004-10, Vol.48 (10), p.3690-3696

2004

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Cloning and characterization of KNR4, a yeast gene involved in (1,3)-beta-glucan synthesis

Molecular and Cellular Biology, 1994-02, Vol.14 (2), p.1017-1025

1994

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Mutations in Aspergillus fumigatus resulting in reduced susceptibility to posaconazole appear to be restricted to a single amino acid in the cytochrome P450 14alpha-demethylase

Antimicrobial agents and chemotherapy, 2003-02, Vol.47 (2), p.577-581

2003

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Enantioselective synthesis of the optical isomers of broad-spectrum orally active antifungal azoles, Sch 42538 and Sch 45012

Bioorganic & medicinal chemistry letters, 1994-08, Vol.4 (16), p.2023-2028

1994

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Cloning and Characterization of KNR4, a Yeast Gene Involved in (1,3)-β-Glucan Synthesis

Molecular and cellular biology, 1994-02, Vol.14 (2), p.1017-1025

1994

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Carbon monoxide and hydroxymercuribenzoate sensitivity of a fatty acid (ω-2) hydroxylase from Bacillus megaterium

Biochemical and biophysical research communications, 1975-07, Vol.65 (2), p.665-672

1975

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Characteristics of a cytochrome P-450-dependent fatty acid ω-2 hydroxylase from Bacillus megaterium

Biochimica et biophysica acta, 1977-06, Vol.487 (3), p.487-494

1977

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Mutations in Aspergillus fumigatus Resulting in Reduced Susceptibility to Posaconazole Appear To Be Restricted to a Single Amino Acid in the Cytochrome P450 14α-Demethylase

Posaconazole Is a Potent Inhibitor of Sterol 14α-Demethylation in Yeasts and Molds

Posaconazole Is Effective as Salvage Therapy in Zygomycosis: A Retrospective Summary of 91 Cases

Activity of posaconazole in the treatment of central nervous system fungal infections

Evernimicin Binds Exclusively to the 50S Ribosomal Subunit and Inhibits Translation in Cell-Free Systems Derived from both Gram-Positive and Gram-Negative Bacteria

Evernimicin (SCH27899) Inhibits a Novel Ribosome Target Site: Analysis of 23S Ribosomal DNA Mutants

Genetic Footprinting in Bacteria

Mutations in Ribosomal Protein L16 Conferring Reduced Susceptibility to Evernimicin (SCH27899): Implications for Mechanism of Action

Effects of Mutations in Ribosomal Protein L16 on Susceptibility and Accumulation of Evernimicin

Changes in susceptibility to posaconazole in clinical isolates of Candida albicans

Efficacy of SCH27899 in an Animal Model of Legionnaires' Disease Using Immunocompromised A/J Mice

Genomics and antimicrobial drug discovery

Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 ( 1), and the discovery of posaconazole [Sch 56592; 2 or ( S, S)- 5]

The use of direct cDNA selection to rapidly and effectively identify genes in the fungus Aspergillus fumigatus

In Vitro and In Vivo Activities of SCH 56592 (Posaconazole), a New Triazole Antifungal Agent, againstAspergillus and Candida

In vitro and in vivo activities of SCH 56592 (Posaconazole), a new triazole antifungal agent, against Aspergillus and Candida

Sch 51048, a novel broad-spectrum orally active antifungal agent: Synthesis and preliminary structure-activity profile

EmtA, a rRNA methyltransferase conferring high‐level evernimicin resistance

Posaconazole is a potent inhibitor of sterol 14alpha-demethylation in yeasts and molds

Cloning and characterization of KNR4, a yeast gene involved in (1,3)-beta-glucan synthesis

Mutations in Aspergillus fumigatus resulting in reduced susceptibility to posaconazole appear to be restricted to a single amino acid in the cytochrome P450 14alpha-demethylase

Enantioselective synthesis of the optical isomers of broad-spectrum orally active antifungal azoles, Sch 42538 and Sch 45012

Cloning and Characterization of KNR4, a Yeast Gene Involved in (1,3)-β-Glucan Synthesis

Carbon monoxide and hydroxymercuribenzoate sensitivity of a fatty acid (ω-2) hydroxylase from Bacillus megaterium

Characteristics of a cytochrome P-450-dependent fatty acid ω-2 hydroxylase from Bacillus megaterium

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