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Therapeutic glucocorticoids: mechanisms of actions in rheumatic diseases

Nature reviews. Rheumatology, 2020-03, Vol.16 (3), p.133-144

2020

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Inflammation and Skeletal Muscle Wasting During Cachexia

Frontiers in physiology, 2020-11, Vol.11, p.597675-597675

2020

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Cortisol excess in chronic kidney disease - A review of changes and impact on mortality

Frontiers in endocrinology (Lausanne), 2023-01, Vol.13, p.1075809-1075809

2023

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Endogenous Glucocorticoid Metabolism in Bone: Friend or Foe

Frontiers in endocrinology (Lausanne), 2021-08, Vol.12, p.733611-733611

2021

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Exploring the Interface between Inflammatory and Therapeutic Glucocorticoid Induced Bone and Muscle Loss

International journal of molecular sciences, 2019-11, Vol.20 (22), p.5768

2019

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Local glucocorticoid synthesis regulates house dust mite-induced airway hypersensitivity in mice

Frontiers in immunology, 2023-10, Vol.14, p.1252874-1252874

2023

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Skeletal muscle dysregulation in rheumatoid arthritis: Metabolic and molecular markers in a rodent model and patients

PloS one, 2020-07, Vol.15 (7), p.e0235702-e0235702

2020

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Global Deletion of 11β-HSD1 Prevents Muscle Wasting Associated with Glucocorticoid Therapy in Polyarthritis

International journal of molecular sciences, 2021-07, Vol.22 (15), p.7828

2021

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11β-Hydroxysteroid Dehydrogenase Type 1 within Osteoclasts Mediates the Bone Protective Properties of Therapeutic Corticosteroids in Chronic Inflammation

International journal of molecular sciences, 2022-06, Vol.23 (13), p.7334

2022

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Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS

Frontiers in immunology, 2023-04, Vol.14, p.1159831-1159831

2023

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Dexamethasone impairs the expression of antimicrobial mediators in lipopolysaccharide-activated primary macrophages by inhibiting both expression and function of interferon β

Frontiers in immunology, 2023-10, Vol.14, p.1190261-1190261

2023

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Glucocorticoids and Bone: Consequences of Endogenous and Exogenous Excess and Replacement Therapy

Endocrine reviews, 2018-10, Vol.39 (5), p.519-548

2018

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Glucocorticoid metabolism in rheumatoid arthritis

Annals of the New York Academy of Sciences, 2014-05, Vol.1318 (1), p.18-26

2014

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Assessment of Alveolar Macrophage Dysfunction Using an in vitro Model of Acute Respiratory Distress Syndrome

Frontiers in medicine, 2021-09, Vol.8, p.737859-737859

2021

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Endogenous glucocorticoids in inflammation: contributions of systemic and local responses

Swiss medical weekly, 2012, Vol.142, p.w13650

2012

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Local steroid activation is a critical mediator of the anti-inflammatory actions of therapeutic glucocorticoids

Annals of the rheumatic diseases, 2021-02, Vol.80 (2), p.250

2021

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Localization, Age- and Site-Dependent Expression, and Regulation of 11β-Hydroxysteroid Dehydrogenase Type 1 in Skin

Journal of investigative dermatology, 2011-01, Vol.131 (1), p.30-36

2011

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11βHSD1 Inhibition with AZD4017 Improves Lipid Profiles and Lean Muscle Mass in Idiopathic Intracranial Hypertension

The journal of clinical endocrinology and metabolism, 2021-01, Vol.106 (1), p.174-187

2021

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Cerebral Oxidative Stress and Microvasculature Defects in TNF-α Expressing Transgenic and Porphyromonas gingivalis-Infected ApoE-/- Mice

Journal of Alzheimer's disease, 2017-01, Vol.60 (2), p.359

2017

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Glucocorticoid activation by 11β‐hydroxysteroid dehydrogenase enzymes in relation to inflammation and glycaemic control in chronic kidney disease: A cross‐sectional study

Clinical endocrinology (Oxford), 2019-01, Vol.90 (1), p.241-249

2019

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GIP reduces osteoclast activity and improves osteoblast survival in primary human bone cells

European journal of endocrinology, 2023-01, Vol.188 (1)

2023

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11β-HSD1 determines the extent of muscle atrophy in a model of acute exacerbation of COPD

American journal of physiology. Lung cellular and molecular physiology, 2023-04, Vol.324 (4), p.L400-L412

2023

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11[beta]-Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation

The Journal of pathology, 2016-12, Vol.240 (4), p.472

2016

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11β-Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation

The Journal of pathology, 2016-12, Vol.240 (4), p.472-483

2016

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TNFα depleting therapy improves fertility and animal welfare in TNFα-driven transgenic models of polyarthritis when administered in their routine breeding

Laboratory animals (London), 2018-02, Vol.52 (1), p.59-68

2018

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Therapeutic glucocorticoids: mechanisms of actions in rheumatic diseases

Inflammation and Skeletal Muscle Wasting During Cachexia

Cortisol excess in chronic kidney disease - A review of changes and impact on mortality

Endogenous Glucocorticoid Metabolism in Bone: Friend or Foe

Exploring the Interface between Inflammatory and Therapeutic Glucocorticoid Induced Bone and Muscle Loss

Local glucocorticoid synthesis regulates house dust mite-induced airway hypersensitivity in mice

Skeletal muscle dysregulation in rheumatoid arthritis: Metabolic and molecular markers in a rodent model and patients

Global Deletion of 11β-HSD1 Prevents Muscle Wasting Associated with Glucocorticoid Therapy in Polyarthritis

11β-Hydroxysteroid Dehydrogenase Type 1 within Osteoclasts Mediates the Bone Protective Properties of Therapeutic Corticosteroids in Chronic Inflammation

Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS

Dexamethasone impairs the expression of antimicrobial mediators in lipopolysaccharide-activated primary macrophages by inhibiting both expression and function of interferon β

Glucocorticoids and Bone: Consequences of Endogenous and Exogenous Excess and Replacement Therapy

Glucocorticoid metabolism in rheumatoid arthritis

Assessment of Alveolar Macrophage Dysfunction Using an in vitro Model of Acute Respiratory Distress Syndrome

Endogenous glucocorticoids in inflammation: contributions of systemic and local responses

Local steroid activation is a critical mediator of the anti-inflammatory actions of therapeutic glucocorticoids

Localization, Age- and Site-Dependent Expression, and Regulation of 11β-Hydroxysteroid Dehydrogenase Type 1 in Skin

11βHSD1 Inhibition with AZD4017 Improves Lipid Profiles and Lean Muscle Mass in Idiopathic Intracranial Hypertension

Cerebral Oxidative Stress and Microvasculature Defects in TNF-α Expressing Transgenic and Porphyromonas gingivalis-Infected ApoE-/- Mice

Glucocorticoid activation by 11β‐hydroxysteroid dehydrogenase enzymes in relation to inflammation and glycaemic control in chronic kidney disease: A cross‐sectional study

GIP reduces osteoclast activity and improves osteoblast survival in primary human bone cells

11β-HSD1 determines the extent of muscle atrophy in a model of acute exacerbation of COPD

11[beta]-Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation

11β-Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation

TNFα depleting therapy improves fertility and animal welfare in TNFα-driven transgenic models of polyarthritis when administered in their routine breeding

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