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Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis

Science (American Association for the Advancement of Science), 2011-04, Vol.332 (6025), p.91-94

2011

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Mutations in a translation initiation factor identify the target of a memory-enhancing compound

Science (American Association for the Advancement of Science), 2015-05, Vol.348 (6238), p.1027-1030

2015

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A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response

Cell, 2017-12, Vol.171 (7), p.1625-1637.e13

2017

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Higher-order phosphatase-substrate contacts terminate the integrated stress response

Nature structural & molecular biology, 2021-10, Vol.28 (10), p.835-846

2021

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Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B

Science (American Association for the Advancement of Science), 2018-03, Vol.359 (6383), p.1533-1536

2018

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Targeting the unfolded protein response in disease

Nature reviews. Drug discovery, 2013-09, Vol.12 (9), p.703-719

2013

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The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells

eLife, 2019-11, Vol.8

2019

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molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

Proceedings of the National Academy of Sciences - PNAS, 2012-04, Vol.109 (15), p.E869-E878

2012

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Translation Reinitiation at Alternative Open Reading Frames Regulates Gene Expression in an Integrated Stress Response

The Journal of cell biology, 2004-10, Vol.167 (1), p.27-33

2004

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Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2α) dephosphorylation in mammalian development

Proceedings of the National Academy of Sciences - PNAS, 2009-02, Vol.106 (6), p.1832-1837

2009

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Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers

Cell reports (Cambridge), 2021-05, Vol.35 (7), p.109144-109144, Article 109144

2021

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CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

Genes & development, 2004-12, Vol.18 (24), p.3066-3077

2004

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A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α

eLife, 2024-07, Vol.13

2024

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Role for the obesity-related FTO gene in the cellular sensing of amino acids

Proceedings of the National Academy of Sciences - PNAS, 2013-02, Vol.110 (7), p.2557-2562

2013

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Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis

The Journal of neuroscience, 2013-04, Vol.33 (14), p.5980-5991

2013

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Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1

Molecular cell, 2010-04, Vol.38 (2), p.291-304

2010

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TRANSCRIPTIONAL AND TRANSLATIONAL CONTROL IN THE MAMMALIAN UNFOLDED PROTEIN RESPONSE

Annual review of cell and developmental biology, 2002-01, Vol.18 (1), p.575-599

2002

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Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response

Genetics (Austin), 2006-09, Vol.174 (1), p.229-239

2006

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Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones

Journal of cell science, 2004-08, Vol.117 (Pt 18), p.4055-4066

2004

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A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly

Diabetes (New York, N.Y.), 2015-11, Vol.64 (11), p.3951-3962

2015

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Infancy‐onset diabetes caused by de‐regulated AMPylation of the human endoplasmic reticulum chaperone BiP

EMBO molecular medicine, 2023-03, Vol.15 (3), p.e16491-n/a

2023

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Translational Repression Mediates Activation of Nuclear Factor Kappa B by Phosphorylated Translation Initiation Factor 2

Molecular and Cellular Biology, 2004-12, Vol.24 (23), p.10161-10168

2004

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Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox

The Journal of cell biology, 2013-04, Vol.201 (2), p.337-349

2013

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Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

Nature (London), 1999-01, Vol.397 (6716), p.271-274

1999

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Regulated translation initiation controls stress-induced gene expression in mammalian cells

Molecular cell, 2000-11, Vol.6 (5), p.1099-1108

2000

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Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis

Mutations in a translation initiation factor identify the target of a memory-enhancing compound

A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response

Higher-order phosphatase-substrate contacts terminate the integrated stress response

Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B

Targeting the unfolded protein response in disease

The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells

molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

Translation Reinitiation at Alternative Open Reading Frames Regulates Gene Expression in an Integrated Stress Response

Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2α) dephosphorylation in mammalian development

Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α

Role for the obesity-related FTO gene in the cellular sensing of amino acids

Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis

Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1

TRANSCRIPTIONAL AND TRANSLATIONAL CONTROL IN THE MAMMALIAN UNFOLDED PROTEIN RESPONSE

Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response

Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones

A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly

Infancy‐onset diabetes caused by de‐regulated AMPylation of the human endoplasmic reticulum chaperone BiP

Translational Repression Mediates Activation of Nuclear Factor Kappa B by Phosphorylated Translation Initiation Factor 2

Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

Regulated translation initiation controls stress-induced gene expression in mammalian cells

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