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RNAi modulation of placental sFLT1 for the treatment of preeclampsia

Nature biotechnology, 2018-12, Vol.36 (12), p.1164-1173

2018

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Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways

Nucleic acids research, 2019-02, Vol.47 (3), p.1070

2019

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Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo

Nucleic acids research, 2018-03, Vol.46 (5), p.2185

2018

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High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources

Journal of extracellular vesicles, 2016-01, Vol.5 (1), p.32570-n/a

2016

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Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier

Molecular therapy, 2018-11, Vol.26 (11), p.2580-2591

2018

Volltextzugriff (PDF)

Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O‑Phosphocholine‑N‑docosahexaenoyl‑l‑serine siRNA Conjugate in Mouse Brain

Bioconjugate chemistry, 2017-06, Vol.28 (6), p.1758-1766

2017

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Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain

Molecular therapy. Nucleic acids, 2016, Vol.5 (8), p.e344-e344, Article e344

2016

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PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs

Molecular therapy. Nucleic acids, 2022-09, Vol.29, p.116-132

2022

Volltextzugriff (PDF)

Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing

Molecular therapy, 2016-10, Vol.24 (10), p.1836-1847

2016

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Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep

JCI insight, 2021-12, Vol.6 (24)

2021

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5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo

Nucleic acids research, 2017-07, Vol.45 (13), p.7581

2017

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Comparative Colocalization Single-Molecule Spectroscopy (CoSMoS) with Multiple RNA Species

Methods in molecular biology (Clifton, N.J.), 2020-01, Vol.2113, p.23

2020

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Loading of Extracellular Vesicles with Hydrophobically Modified siRNAs

Methods in molecular biology (Clifton, N.J.), 2018, Vol.1740, p.199

2018

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Hydrophobicity of Lipid-Conjugated siRNAs Predicts Productive Loading to Small Extracellular Vesicles

Molecular therapy, 2018-06, Vol.26 (6), p.1520-1528

2018

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Synthesis and biological properties of triazole-linked locked nucleic acid

Chemical communications (Cambridge, England), 2017-08, Vol.53 (63), p.8906-8909

2017

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A new frontier in atherosclerotic coronary imaging

The Lancet (British edition), 2014-02, Vol.383 (9918), p.674-675

2014

Volltextzugriff (PDF)

Chitosan-Mangafodipir nanoparticles designed for intranasal delivery of siRNA and DNA to brain

Journal of drug delivery science and technology, 2018-02, Vol.43, p.453-460

2018

Volltextzugriff (PDF)

Loading of Extracellular Vesicles with Chemically Stabilized Hydrophobic siRNAs for the Treatment of Disease in the Central Nervous System

Bio-protocol, 2017-06, Vol.7 (20)

2017

Volltextzugriff (PDF)

Preparation of SNAP f -Beads for Colocalization Single-Molecule Spectroscopy (CoSMoS) of RNA-Protein Complexes

Methods in molecular biology (Clifton, N.J.), 2020, Vol.2113, p.17

2020

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Synthesis and biological properties of triazole-linked locked nucleic acidElectronic supplementary information (ESI) available: Experimental methods and additional data. See DOI: 10.1039/c7cc04092j

2017-08

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Chimeric miRNA cluster enables multiplex and titratable gene inhibition in CAR-T cells

Molecular therapy. Nucleic acids, 2023-12, Vol.34, p.102077-102077, Article 102077

Haraszti, Reka Agnes

2023

Volltextzugriff (PDF)

Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo

Nucleic acids research, 2019-02, Vol.47 (3), p.1082

2019

Volltextzugriff (PDF)

RNA Therapeutics for Improving CAR T-cell Safety and Efficacy

Cancer research (Chicago, Ill.), 2023-02, Vol.83 (3), p.354-362

2023

Volltextzugriff (PDF)

Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles

Molecular therapy, 2018-08, Vol.26 (8), p.1973-1982

2018

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RNAi modulation of placental sFLT1 for the treatment of preeclampsia

A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system

Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways

Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo

High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources

Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier

Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O‑Phosphocholine‑N‑docosahexaenoyl‑l‑serine siRNA Conjugate in Mouse Brain

Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain

PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs

Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing

Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep

5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo

Comparative Colocalization Single-Molecule Spectroscopy (CoSMoS) with Multiple RNA Species

Loading of Extracellular Vesicles with Hydrophobically Modified siRNAs

Hydrophobicity of Lipid-Conjugated siRNAs Predicts Productive Loading to Small Extracellular Vesicles

Synthesis and biological properties of triazole-linked locked nucleic acid

A new frontier in atherosclerotic coronary imaging

Chitosan-Mangafodipir nanoparticles designed for intranasal delivery of siRNA and DNA to brain

Loading of Extracellular Vesicles with Chemically Stabilized Hydrophobic siRNAs for the Treatment of Disease in the Central Nervous System

Preparation of SNAP f -Beads for Colocalization Single-Molecule Spectroscopy (CoSMoS) of RNA-Protein Complexes

Synthesis and biological properties of triazole-linked locked nucleic acidElectronic supplementary information (ESI) available: Experimental methods and additional data. See DOI: 10.1039/c7cc04092j

Chimeric miRNA cluster enables multiplex and titratable gene inhibition in CAR-T cells

Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo

RNA Therapeutics for Improving CAR T-cell Safety and Efficacy

Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles

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