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Microglia in Alzheimer's disease

The Journal of cell biology, 2018-02, Vol.217 (2), p.459-472

2018

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Development and Evolution of the Human Neocortex

Cell, 2011-07, Vol.146 (1), p.18-36

2011

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TREM2, Microglia, and Neurodegenerative Diseases

Trends in molecular medicine, 2017-06, Vol.23 (6), p.512-533

2017

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Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model

The Journal of neuroscience, 2020-02, Vol.40 (9), p.1956-1974

2020

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Alzheimer’s Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation

Cell reports (Cambridge), 2020-06, Vol.31 (13), p.107843-107843, Article 107843

2020

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Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

Cell reports (Cambridge), 2019-08, Vol.28 (8), p.2111-2123.e6

2019

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Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models

Cell reports (Cambridge), 2018-01, Vol.22 (3), p.832-847

2018

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Neurogenic radial glia in the outer subventricular zone of human neocortex

Nature (London), 2010-03, Vol.464 (7288), p.554-561

2010

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A High-Resolution Enhancer Atlas of the Developing Telencephalon

Cell, 2013-02, Vol.152 (4), p.895-908

2013

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Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses

Nature communications, 2016-04, Vol.7 (1), p.11295-11295, Article 11295

2016

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Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences

Nature neuroscience, 2013-11, Vol.16 (11), p.1576-1587

2013

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Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex

Nature communications, 2013, Vol.4 (1), p.1665-1665, Article 1665

2013

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Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation

The Journal of experimental medicine, 2017-09, Vol.214 (9), p.2611-2628

2017

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Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease

PLoS genetics, 2018-11, Vol.14 (11), p.e1007427-e1007427

2018

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A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death

Nature medicine, 2014-12, Vol.20 (12), p.1452-1457

2014

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Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining

Nature communications, 2024-09, Vol.15 (1), p.8382-15, Article 8382

2024

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Deriving Excitatory Neurons of the Neocortex from Pluripotent Stem Cells

Neuron (Cambridge, Mass.), 2011-05, Vol.70 (4), p.645-660

2011

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Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement

Cell reports (Cambridge), 2016-08, Vol.16 (6), p.1690-1700

2016

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Mouse Emi2 is required to enter meiosis II by reestablishing cyclin B1 during interkinesis

The Journal of cell biology, 2006-09, Vol.174 (6), p.791-801

2006

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Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor

Genes & development, 2006-09, Vol.20 (17), p.2410-2420

2006

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CaMKII and Polo-Like Kinase 1 Sequentially Phosphorylate the Cytostatic Factor Emi2/XErp1 to Trigger Its Destruction and Meiotic Exit

Proceedings of the National Academy of Sciences - PNAS, 2006-01, Vol.103 (3), p.608-613

2006

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A Role for the Anaphase-Promoting Complex Inhibitor Emi2/XErp1, a Homolog of Early Mitotic Inhibitor 1, in Cytostatic Factor Arrest of Xenopus Eggs

Proceedings of the National Academy of Sciences - PNAS, 2005-03, Vol.102 (12), p.4318-4323

2005

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Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology

Neuron (Cambridge, Mass.), 2021-04, Vol.109 (8), p.1283-1301.e6

2021

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TREM2-independent oligodendrocyte, astrocyte, and T cell responses to tau and amyloid pathology in mouse models of Alzheimer disease

Cell reports (Cambridge), 2021-12, Vol.37 (13), p.110158-110158, Article 110158

2021

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Genome-Wide Analysis of Differential Gene Expression and Splicing in Excitatory Neurons and Interneuron Subtypes

The Journal of neuroscience, 2020-01, Vol.40 (5), p.958-973

2020

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Microglia in Alzheimer's disease

Development and Evolution of the Human Neocortex

TREM2, Microglia, and Neurodegenerative Diseases

Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model

Alzheimer’s Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models

Neurogenic radial glia in the outer subventricular zone of human neocortex

A High-Resolution Enhancer Atlas of the Developing Telencephalon

Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses

Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences

Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex

Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation

Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease

A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death

Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining

Deriving Excitatory Neurons of the Neocortex from Pluripotent Stem Cells

Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement

Mouse Emi2 is required to enter meiosis II by reestablishing cyclin B1 during interkinesis

Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor

CaMKII and Polo-Like Kinase 1 Sequentially Phosphorylate the Cytostatic Factor Emi2/XErp1 to Trigger Its Destruction and Meiotic Exit

A Role for the Anaphase-Promoting Complex Inhibitor Emi2/XErp1, a Homolog of Early Mitotic Inhibitor 1, in Cytostatic Factor Arrest of Xenopus Eggs

Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology

TREM2-independent oligodendrocyte, astrocyte, and T cell responses to tau and amyloid pathology in mouse models of Alzheimer disease

Genome-Wide Analysis of Differential Gene Expression and Splicing in Excitatory Neurons and Interneuron Subtypes

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