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Structure and activation of C1, the complex initiating the classical pathway of the complement cascade

Proceedings of the National Academy of Sciences - PNAS, 2017-01, Vol.114 (5), p.986-991

2017

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Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function

The Journal of immunology (1950), 2012-10, Vol.189 (8), p.3957-3969

2012

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Analysis of Factor D Isoforms in Malpuech-Michels-Mingarelli-Carnevale Patients Highlights the Role of MASP-3 as a Maturase in the Alternative Pathway of Complement

The Journal of immunology (1950), 2017-09, Vol.199 (6), p.2158-2170

2017

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Complement activation by ligand-driven juxtaposition of discrete pattern recognition complexes

Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (37), p.13445-13450

2014

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Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System

Frontiers in immunology, 2020-07, Vol.11, p.1504-1504

2020

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Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin–Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H–Related Protein-5 (FHR5) Deposition

Kidney international reports, 2018-03, Vol.3 (2), p.426-438

2018

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Plasma Lectin Pathway Complement Proteins in Patients With COVID-19 and Renal Disease

Frontiers in immunology, 2021-04, Vol.12, p.671052-671052

2021

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Investigations on the pattern recognition molecule M-ficolin: quantitative aspects of bacterial binding and leukocyte association

Journal of leukocyte biology, 2011-09, Vol.90 (3), p.425-437

2011

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Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D

Frontiers in immunology, 2020-02, Vol.11, p.201-201

2020

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A Single-Domain Antibody Targeting Complement Component C5 Acts as a Selective Inhibitor of the Terminal Pathway of the Complement System and Thus Functionally Mimicks the C-Terminal Domain of the Staphylococcus aureus SSL7 Protein

Frontiers in immunology, 2018-11, Vol.9, p.2822-2822

2018

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Inter-α-trypsin inhibitor heavy chain 4 (ITIH4) as a compensatory protease inhibitor in hereditary angioedema

Journal of allergy and clinical immunology, 2024-08, Vol.154 (2), p.468-479.e6

2024

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M-Ficolin Binds Selectively to the Capsular Polysaccharides of Streptococcus pneumoniae Serotypes 19B and 19C and of a Streptococcus mitis Strain

Infection and Immunity, 2013-02, Vol.81 (2), p.452-459

2013

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Trypanosoma brucei Invariant Surface gp65 Inhibits the Alternative Pathway of Complement by Accelerating C3b Degradation

The Journal of immunology (1950), 2023-09, Vol.211 (5), p.862-873

2023

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A C3-specific nanobody that blocks all three activation pathways in the human and murine complement system

The Journal of biological chemistry, 2020-06, Vol.295 (26), p.8746-8758

2020

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Bispecific Complement Engagers for Targeted Complement Activation

The Journal of immunology (1950), 2023-08, Vol.211 (3), p.403-413

2023

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Ficolin-3 Deficiency Is Associated with Disease and an Increased Risk of Systemic Lupus Erythematosus

Journal of clinical immunology, 2019-05, Vol.39 (4), p.421-429

2019

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MAp44, a Human Protein Associated with Pattern Recognition Molecules of the Complement System and Regulating the Lectin Pathway of Complement Activation

The Journal of immunology (1950), 2009-12, Vol.183 (11), p.7371-7378

2009

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Recruitment of properdin by bi-specific nanobodies activates the alternative pathway of complement

Molecular immunology, 2020-08, Vol.124, p.200-210

2020

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A Complement C3-Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity

The Journal of immunology (1950), 2020-10, Vol.205 (8), p.2287-2300

2020

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Endogenous Natural Complement Inhibitor Regulates Cardiac Development

The Journal of immunology (1950), 2017-04, Vol.198 (8), p.3118-3126

2017

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MAp19, the alternative splice product of the MASP2 gene

Journal of immunological methods, 2011-10, Vol.373 (1-2), p.89-101

2011

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ITIH4 acts as a protease inhibitor by a novel inhibitory mechanism

Science advances, 2021-01, Vol.7 (2)

2021

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Polymorphisms in Mannan-Binding Lectin (MBL)-Associated Serine Protease 2 Affect Stability, Binding to MBL, and Enzymatic Activity

The Journal of immunology (1950), 2009-03, Vol.182 (5), p.2939-2947

2009

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Factors involved in initiation and regulation of complement lectin pathway influence postoperative outcome after pediatric cardiac surgery involving cardiopulmonary bypass

Scientific reports, 2019-02, Vol.9 (1), p.2930-2930, Article 2930

2019

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Mannan-binding lectin (MBL) associated serine proteases in mice

Immunobiology (1979), 2016-10, Vol.221 (10), p.1214-1215

2016

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Structure and activation of C1, the complex initiating the classical pathway of the complement cascade

Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function

Analysis of Factor D Isoforms in Malpuech-Michels-Mingarelli-Carnevale Patients Highlights the Role of MASP-3 as a Maturase in the Alternative Pathway of Complement

Complement activation by ligand-driven juxtaposition of discrete pattern recognition complexes

Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System

Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin–Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H–Related Protein-5 (FHR5) Deposition

Plasma Lectin Pathway Complement Proteins in Patients With COVID-19 and Renal Disease

Investigations on the pattern recognition molecule M-ficolin: quantitative aspects of bacterial binding and leukocyte association

Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D

A Single-Domain Antibody Targeting Complement Component C5 Acts as a Selective Inhibitor of the Terminal Pathway of the Complement System and Thus Functionally Mimicks the C-Terminal Domain of the Staphylococcus aureus SSL7 Protein

Inter-α-trypsin inhibitor heavy chain 4 (ITIH4) as a compensatory protease inhibitor in hereditary angioedema

M-Ficolin Binds Selectively to the Capsular Polysaccharides of Streptococcus pneumoniae Serotypes 19B and 19C and of a Streptococcus mitis Strain

Trypanosoma brucei Invariant Surface gp65 Inhibits the Alternative Pathway of Complement by Accelerating C3b Degradation

A C3-specific nanobody that blocks all three activation pathways in the human and murine complement system

Bispecific Complement Engagers for Targeted Complement Activation

Ficolin-3 Deficiency Is Associated with Disease and an Increased Risk of Systemic Lupus Erythematosus

MAp44, a Human Protein Associated with Pattern Recognition Molecules of the Complement System and Regulating the Lectin Pathway of Complement Activation

Recruitment of properdin by bi-specific nanobodies activates the alternative pathway of complement

A Complement C3-Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity

Endogenous Natural Complement Inhibitor Regulates Cardiac Development

MAp19, the alternative splice product of the MASP2 gene

ITIH4 acts as a protease inhibitor by a novel inhibitory mechanism

Polymorphisms in Mannan-Binding Lectin (MBL)-Associated Serine Protease 2 Affect Stability, Binding to MBL, and Enzymatic Activity

Factors involved in initiation and regulation of complement lectin pathway influence postoperative outcome after pediatric cardiac surgery involving cardiopulmonary bypass

Mannan-binding lectin (MBL) associated serine proteases in mice

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