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Linaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine 3′,5′-Monophosphate

Gastroenterology (New York, N.Y. 1943), 2013-12, Vol.145 (6), p.1334-1346.e11

2013

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Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

European journal of pharmacology, 2010-12, Vol.649 (1), p.328-335

2010

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Experimentally Induced Bladder Permeability Evokes Bladder Afferent Hypersensitivity in the Absence of Inflammation

Frontiers in neuroscience, 2020-10, Vol.14, p.590871-590871

2020

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Linaclotide activates guanylate cyclase‐C/cGMP/protein kinase‐II‐dependent trafficking of CFTR in the intestine

Physiological reports, 2017-06, Vol.5 (11), p.e13299-n/a

2017

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A Methionine Aminopeptidase-2 Inhibitor, PPI-2458, for the Treatment of Rheumatoid Arthritis

Proceedings of the National Academy of Sciences - PNAS, 2004-07, Vol.101 (29), p.10768-10773

2004

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EP1238: COLORECTAL NOCICEPTIVE PROCESSING IN THE CAUDAL VENTROLATERAL MEDULLA AND THE LATERAL PARABRACHIAL NUCLEI IS INCREASED IN A MOUSE MODEL OF CHRONIC VISCERAL HYPERSENSITIVITY AND IS REVERSED BY CHRONIC LINACLOTIDE TREATMENT

Gastroenterology (New York, N.Y. 1943), 2022-05, Vol.162 (7), p.S-1074-S-1075

2022

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Guanylate cyclase 2C agonism corrects CFTR mutants

JCI insight, 2017-10, Vol.2 (19)

2017

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Su136 COLORECTAL NOCICEPTIVE PROCESSING IN THE ROSTRAL VENTROMEDIAL AND CAUDAL VENTROLATERAL MEDULLA IS INCREASED IN A MOUSE MODEL OF CHRONIC VISCERAL HYPERSENSITIVITY AND IS REVERSED BY CHRONIC LINACLOTIDE TREATMENT

Gastroenterology (New York, N.Y. 1943), 2021-05, Vol.160 (6), p.S-630-S-630

2021

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Su134 INTRACOLONIC ADMINISTRATION OF LINACLOTIDE RELIEVES VISCERAL HYPERSENSITIVITY BY INHIBITING CHRONIC PSYCHOLOGICAL STRESS-INDUCED ACTIVATION OF CENTRAL NOCICEPTIVE PATHWAYS IN RATS

Gastroenterology (New York, N.Y. 1943), 2021-05, Vol.160 (6), p.S-629-S-630

2021

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Su1220 ATTENUATION OF STRESS-INDUCED ACTIVATION OF SUPRASPINAL PAIN CIRCUITS CONTRIBUTES TO ANTI-NOCICEPTIVE EFFECTS OF LINACLOTIDE

Gastroenterology (New York, N.Y. 1943), 2020-05, Vol.158 (6), p.S-548-S-548

2020

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240: COLON-TARGETED DELIVERY OF GUANYLATE CYCLASE-C AGONIST IW-3300 RELIEVES COMORBID CHRONIC PELVIC AND SOMATIC PAIN IN A RAT MODEL OF EARLY LIFE STRESS-INDUCED COLONIC HYPERSENSITIVITY

Gastroenterology (New York, N.Y. 1943), 2022-05, Vol.162 (7), p.S-48-S-48

2022

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EP1239: DESCENDING PAIN MODULATION OF COLORECTAL NOCICEPTIVE PROCESSING IN THE SPINAL CORD IS IMBALANCED IN A MOUSE MODEL OF POST-COLITIS CHRONIC VISCERAL HYPERSENSITIVITY AND IS REDUCED BY CHRONIC ORAL LINACLOTIDE TREATMENT

Gastroenterology (New York, N.Y. 1943), 2022-05, Vol.162 (7), p.S-1075

2022

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Guanylate cyclase-C agonists as peripherally acting treatments of chronic visceral pain

Trends in pharmacological sciences (Regular ed.), 2022-02, Vol.43 (2), p.110-122

2022

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1017 - Guanylate Cyclase 2C Activation Rescues the Folding Defect in F508Del CFTR

Gastroenterology (New York, N.Y. 1943), 2018-05, Vol.154 (6), p.S-193-S-193

2018

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Mo1515 - Bile Acid Sequestrant Shows Effects on the Contractile Activity of Ex Vivo Lower Esophageal Sphincter Muscle

Gastroenterology (New York, N.Y. 1943), 2018-05, Vol.154 (6), p.S-736-S-736

2018

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Linaclotide treatment reduces endometriosis-associated vaginal hyperalgesia and mechanical allodynia through viscerovisceral cross-talk

Pain (Amsterdam), 2019-11, Vol.160 (11), p.2566-2579

2019

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Mo1146 CHRONIC INTRA-COLONIC LINACLOTIDE ADMINISTRATION ALTERS GLIAL ACTIVATION IN A MOUSE MODEL OF CHRONIC VISCERAL HYPERSENSITIVITY

Gastroenterology (New York, N.Y. 1943), 2020-05, Vol.158 (6), p.S-803-S-803

2020

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Sa1677 – Chronic Colonic Administration of the Guanylate Cyclase-C Agonist Linaclotide Attenuates Colitis Induced Bladder Afferent Hyperactivity

Gastroenterology (New York, N.Y. 1943), 2019-05, Vol.156 (6), p.S-363-S-363

2019

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Sa1681 – Gc-C Agonism with Linaclotide Attenuates Chronic Stressinduced Colonic Hypersensitivity Independently of Elevated Crf Expression in the Central Nucleus of the Amygdala

Gastroenterology (New York, N.Y. 1943), 2019-05, Vol.156 (6), p.S-364-S-364

2019

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Peripheral Guanylate Cyclase‐C modulation of corticolimbic activation and corticotropin‐releasing factor signaling in a rat model of stress‐induced colonic hypersensitivity

Neurogastroenterology and motility, 2021-03, Vol.33 (3), p.e14076-n/a

2021

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Su1578 – Chronic Intracolonic Administration of Linaclotide Inhibits Nociceptive Signaling in a Mouse Model of Chronic Visceral Hypersensitivity

Gastroenterology (New York, N.Y. 1943), 2019-05, Vol.156 (6), p.S-570-S-570

2019

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Linaclotide Attenuates Visceral Organ Crosstalk: Role of Guanylate Cyclase-C Activation in Reversing Bladder-Colon Cross-Sensitization

The Journal of pharmacology and experimental therapeutics, 2018-08, Vol.366 (2), p.274-281

2018

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A Novel Methionine Aminopeptidase-2 Inhibitor, PPI-2458, Inhibits Non–Hodgkin's Lymphoma Cell Proliferation In vitro and In vivo

Clinical cancer research, 2006-04, Vol.12 (8), p.2583-2590

2006

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Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation

The Journal of pharmacology and experimental therapeutics, 2013-01, Vol.344 (1), p.196-206

2013

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Mo1541 - Oral Administration of the Gut-Restricted Guanylate Cyclase-C Agonist, Linaclotide, Reduces Endometriosis-Induced Vaginal Hyperalgesia

Gastroenterology (New York, N.Y. 1943), 2017-04, Vol.152 (5), p.S711-S711

2017

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Linaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine 3′,5′-Monophosphate

Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

Experimentally Induced Bladder Permeability Evokes Bladder Afferent Hypersensitivity in the Absence of Inflammation

Linaclotide activates guanylate cyclase‐C/cGMP/protein kinase‐II‐dependent trafficking of CFTR in the intestine

A Methionine Aminopeptidase-2 Inhibitor, PPI-2458, for the Treatment of Rheumatoid Arthritis

EP1238: COLORECTAL NOCICEPTIVE PROCESSING IN THE CAUDAL VENTROLATERAL MEDULLA AND THE LATERAL PARABRACHIAL NUCLEI IS INCREASED IN A MOUSE MODEL OF CHRONIC VISCERAL HYPERSENSITIVITY AND IS REVERSED BY CHRONIC LINACLOTIDE TREATMENT

Guanylate cyclase 2C agonism corrects CFTR mutants

Su136 COLORECTAL NOCICEPTIVE PROCESSING IN THE ROSTRAL VENTROMEDIAL AND CAUDAL VENTROLATERAL MEDULLA IS INCREASED IN A MOUSE MODEL OF CHRONIC VISCERAL HYPERSENSITIVITY AND IS REVERSED BY CHRONIC LINACLOTIDE TREATMENT

Su134 INTRACOLONIC ADMINISTRATION OF LINACLOTIDE RELIEVES VISCERAL HYPERSENSITIVITY BY INHIBITING CHRONIC PSYCHOLOGICAL STRESS-INDUCED ACTIVATION OF CENTRAL NOCICEPTIVE PATHWAYS IN RATS

Su1220 ATTENUATION OF STRESS-INDUCED ACTIVATION OF SUPRASPINAL PAIN CIRCUITS CONTRIBUTES TO ANTI-NOCICEPTIVE EFFECTS OF LINACLOTIDE

240: COLON-TARGETED DELIVERY OF GUANYLATE CYCLASE-C AGONIST IW-3300 RELIEVES COMORBID CHRONIC PELVIC AND SOMATIC PAIN IN A RAT MODEL OF EARLY LIFE STRESS-INDUCED COLONIC HYPERSENSITIVITY

EP1239: DESCENDING PAIN MODULATION OF COLORECTAL NOCICEPTIVE PROCESSING IN THE SPINAL CORD IS IMBALANCED IN A MOUSE MODEL OF POST-COLITIS CHRONIC VISCERAL HYPERSENSITIVITY AND IS REDUCED BY CHRONIC ORAL LINACLOTIDE TREATMENT

Guanylate cyclase-C agonists as peripherally acting treatments of chronic visceral pain

1017 - Guanylate Cyclase 2C Activation Rescues the Folding Defect in F508Del CFTR

Mo1515 - Bile Acid Sequestrant Shows Effects on the Contractile Activity of Ex Vivo Lower Esophageal Sphincter Muscle

Linaclotide treatment reduces endometriosis-associated vaginal hyperalgesia and mechanical allodynia through viscerovisceral cross-talk

Mo1146 CHRONIC INTRA-COLONIC LINACLOTIDE ADMINISTRATION ALTERS GLIAL ACTIVATION IN A MOUSE MODEL OF CHRONIC VISCERAL HYPERSENSITIVITY

Sa1677 – Chronic Colonic Administration of the Guanylate Cyclase-C Agonist Linaclotide Attenuates Colitis Induced Bladder Afferent Hyperactivity

Sa1681 – Gc-C Agonism with Linaclotide Attenuates Chronic Stressinduced Colonic Hypersensitivity Independently of Elevated Crf Expression in the Central Nucleus of the Amygdala

Peripheral Guanylate Cyclase‐C modulation of corticolimbic activation and corticotropin‐releasing factor signaling in a rat model of stress‐induced colonic hypersensitivity

Su1578 – Chronic Intracolonic Administration of Linaclotide Inhibits Nociceptive Signaling in a Mouse Model of Chronic Visceral Hypersensitivity

Linaclotide Attenuates Visceral Organ Crosstalk: Role of Guanylate Cyclase-C Activation in Reversing Bladder-Colon Cross-Sensitization

A Novel Methionine Aminopeptidase-2 Inhibitor, PPI-2458, Inhibits Non–Hodgkin's Lymphoma Cell Proliferation In vitro and In vivo

Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation

Mo1541 - Oral Administration of the Gut-Restricted Guanylate Cyclase-C Agonist, Linaclotide, Reduces Endometriosis-Induced Vaginal Hyperalgesia

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