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Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders

Journal of medicinal chemistry, 2021-10, Vol.64 (19), p.14773-14792

2021

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Synthesis Optimization, Scale-Up, and Catalyst Screening Efforts toward the MGAT2 Clinical Candidate, BMS-963272

Organic process research & development, 2022-04, Vol.26 (4), p.1327-1335

2022

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Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy

Journal of medicinal chemistry, 2019-08, Vol.62 (16), p.7400-7416

2019

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Phenylimidazoles as Potent and Selective Inhibitors of Coagulation Factor XIa with in Vivo Antithrombotic Activity

Journal of medicinal chemistry, 2014-12, Vol.57 (23), p.9915-9932

2014

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Characterization of monoacylglycerol acyltransferase 2 inhibitors by a novel probe in binding assays

Analytical biochemistry, 2016-05, Vol.501, p.48-55

2016

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Pyridine and pyridinone-based factor XIa inhibitors

Bioorganic & medicinal chemistry letters, 2015-02, Vol.25 (4), p.925-930

2015

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PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor

ACS medicinal chemistry letters, 2018-07, Vol.9 (7), p.673-678

2018

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Design and SAR of selective T-type calcium channel antagonists containing a biaryl sulfonamide core

Bioorganic & medicinal chemistry, 2008-01, Vol.18 (2), p.474-478

2008

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Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta

Bioorganic & medicinal chemistry letters, 2004-07, Vol.14 (13), p.3549-3553

2004

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Characterization of the in vitro cyclization chemistry of calicheamicin and its relation to DNA cleavage

Journal of the American Chemical Society, 1990-05, Vol.112 (11), p.4554-4556

1990

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General Approach to the Synthesis of Specifically Deuterium-Labeled Nucleosides

Journal of organic chemistry, 1994-05, Vol.59 (10), p.2715-2723

1994

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A new class of high affinity thyromimetics containing a phenyl-naphthylene core

Bioorganic & medicinal chemistry letters, 2005-10, Vol.15 (20), p.4579-4584

2005

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Specific abstraction of the 5'S- and 4'-deoxyribosyl hydrogen atoms from DNA by calicheamicin .gamma.1I

Journal of the American Chemical Society, 1992-11, Vol.114 (23), p.9200-9202

1992

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Cell-Type Specific and Ligand Specific Enhancement of Cellular Uptake of Oligodeoxynucleoside Methylphosphonates Covalently Linked with a Neoglycopeptide, YEE(ah-GalNAc)3

Bioconjugate chemistry, 1995-11, Vol.6 (6), p.695-701

1995

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Corrigendum to “A new class of high affinity thyromimetics containing a phenyl-naphthylene core” [Bioorg. Med. Chem. Lett. 15 (2005) 4579–4584]

Bioorganic & medicinal chemistry letters, 2006, Vol.16 (2), p.473-473

2006

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Stereochemistry of titanium-assisted additions of organoaluminum compounds to hydroxybicyclo[2.2.1]hept-2-enes

Organometallics, 1983-11, Vol.2 (11), p.1545-1549

1983

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Concerning the syntheses and structure of 2,3-dihydro-1,4-diphenyl-2,3-triphenylenedicarboxylic anhydride

Journal of chemical education, 1985-01, Vol.62 (1), p.79

1985

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Synthesis of deuterium-labeled atorvastatin and its metabolites for use as internal standards in a LC/MS/MS method developed for quantitation of the drug and its metabolites in human serum

Journal of labelled compounds & radiopharmaceuticals, 2000-03, Vol.43 (3), p.261-270

2000

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Thyroid Receptor Ligands. Part 2. Thyromimetics with Improved Selectivity for the Thyroid Hormone Receptor Beta

ChemInform, 2004-10, Vol.35 (43), p.no-no

2004

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A New Class of High Affinity Thyromimetics Containing a Phenyl-naphthylene Core

ChemInform, 2005-12, Vol.36 (52), p.no-no

2005

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Tissue Distribution and Metabolism of the [ 32 P]-Labeled Oligodeoxynucleoside Methylphosphonate-Neoglycopeptide Conjugate, [YEE(ah-GalNAc) 3 ]-SMCC-AET-pU m p T 7 , in the Mouse

Antisense & nucleic acid drug development, 1997-06, Vol.7 (3), p.141-149

1997

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Identification and validation of G protein-coupled receptors modulating flow-dependent signaling pathways in vascular endothelial cells

Frontiers in molecular biosciences, 2023-06, Vol.10, p.1198079-1198079

2023

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Use of affinity capillary electrophoresis for the study of protein and drug interactions

Analyst (London), 1998, Vol.123 (7), p.1455-1459

1998

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Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders

Synthesis Optimization, Scale-Up, and Catalyst Screening Efforts toward the MGAT2 Clinical Candidate, BMS-963272

Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy

Phenylimidazoles as Potent and Selective Inhibitors of Coagulation Factor XIa with in Vivo Antithrombotic Activity

Characterization of monoacylglycerol acyltransferase 2 inhibitors by a novel probe in binding assays

Pyridine and pyridinone-based factor XIa inhibitors

PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor

Design and SAR of selective T-type calcium channel antagonists containing a biaryl sulfonamide core

Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta

Characterization of the in vitro cyclization chemistry of calicheamicin and its relation to DNA cleavage

General Approach to the Synthesis of Specifically Deuterium-Labeled Nucleosides

A new class of high affinity thyromimetics containing a phenyl-naphthylene core

Specific abstraction of the 5'S- and 4'-deoxyribosyl hydrogen atoms from DNA by calicheamicin .gamma.1I

Cell-Type Specific and Ligand Specific Enhancement of Cellular Uptake of Oligodeoxynucleoside Methylphosphonates Covalently Linked with a Neoglycopeptide, YEE(ah-GalNAc)3

Corrigendum to “A new class of high affinity thyromimetics containing a phenyl-naphthylene core” [Bioorg. Med. Chem. Lett. 15 (2005) 4579–4584]

Stereochemistry of titanium-assisted additions of organoaluminum compounds to hydroxybicyclo[2.2.1]hept-2-enes

Concerning the syntheses and structure of 2,3-dihydro-1,4-diphenyl-2,3-triphenylenedicarboxylic anhydride

Synthesis of deuterium-labeled atorvastatin and its metabolites for use as internal standards in a LC/MS/MS method developed for quantitation of the drug and its metabolites in human serum

Thyroid Receptor Ligands. Part 2. Thyromimetics with Improved Selectivity for the Thyroid Hormone Receptor Beta

A New Class of High Affinity Thyromimetics Containing a Phenyl-naphthylene Core

Tissue Distribution and Metabolism of the [ 32 P]-Labeled Oligodeoxynucleoside Methylphosphonate-Neoglycopeptide Conjugate, [YEE(ah-GalNAc) 3 ]-SMCC-AET-pU m p T 7 , in the Mouse

Identification and validation of G protein-coupled receptors modulating flow-dependent signaling pathways in vascular endothelial cells

Use of affinity capillary electrophoresis for the study of protein and drug interactions

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