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Drug Selectivity: An Evolving Concept in Medicinal Chemistry

1, 2018

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Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity

Nucleic acids research, 2014-11, Vol.42 (20), p.12555

2014

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Synthesis of Novel Curcumin Analogues and Their Evaluation as Selective Cyclooxygenase-1 (COX-1) Inhibitors

Chemical and Pharmaceutical Bulletin, 2007, Vol.55(1), pp.64-71

2007

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The quality of drugs and drug products - Always guaranteed?

Journal of pharmaceutical and biomedical analysis, 2024-02, Vol.239, p.115880-115880, Article 115880

2024

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Antioxidant activity of resveratrol, piceatannol and 3,3',4,4',5,5'-hexahydroxy-trans-stilbene in three leukemia cell lines

Oncology reports, 2006-09, Vol.16 (3), p.617-624

2006

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Novel Resveratrol Derivatives Induce Apoptosis and Cause Cell Cycle Arrest in Prostate Cancer Cell Lines

Anticancer research, 2007-09, Vol.27 (5A), p.3459-3464

2007

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New approaches to treating pain

Bioorganic & medicinal chemistry letters, 2016-02, Vol.26 (4), p.1103-1119

2016

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Ball milling - a new concept for predicting degradation profiles in active pharmaceutical ingredients

Chemical communications (Cambridge, England), 2021-11, Vol.57 (9), p.11956-11959

2021

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Antioxidant, prooxidant and cytotoxic activity of hydroxylated resveratrol analogues: structure–activity relationship

Biochemical pharmacology, 2005-03, Vol.69 (6), p.903-912

2005

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Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure–activity relationship

Bioorganic & medicinal chemistry, 2004-11, Vol.12 (21), p.5571-5578

2004

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Mechanochemical Oxidative Degradation of Thienopyridine Containing Drugs: Toward a Simple Tool for the Prediction of Drug Stability

ACS central science, 2023-06, Vol.9 (6), p.1150-1159

2023

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Antiproliferative and Pro-apoptotic Activities of a Novel Resveratrol Prodrug Against Jurkat CD4+ T-Cells

Anticancer research, 2016-02, Vol.36 (2), p.683

2016

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Drug Selectivity

2017

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A tetracyclic thiophene trimer synthesis and mechanism of formation

Tetrahedron letters, 2013-05, Vol.54 (21), p.2696-2698

2013

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A Novel Genistein Prodrug: Design, Synthesis and Bioactivity on Mouse RAW264.7 Macrophages

Natural product communications, 2016-10, Vol.11 (10), p.1437-1440

2016

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‘Bridged’ stilbene derivatives as selective cyclooxygenase-1 inhibitors

Bioorganic & medicinal chemistry, 2007-09, Vol.15 (18), p.6109-6118

2007

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Cytotoxic and biochemical effects of 3,3′,4,4′,5,5′-hexahydroxystilbene, a novel resveratrol analog in HL-60 human promyelocytic leukemia cells

Experimental hematology, 2006-10, Vol.34 (10), p.1377-1384

2006

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Novel resveratrol analogs induce apoptosis and cause cell cycle arrest in HT29 human colon cancer cells : Inhibition of ribonucleotide reductase activity

Oncology reports, 2008-06, Vol.19 (6), p.1621-1626

2008

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Benzanilides with spasmolytic activity: Chemistry, pharmacology, and SAR

Bioorganic & medicinal chemistry, 2008-06, Vol.16 (11), p.5974-5981

2008

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No evidence for modulation of endothelial nitric oxide synthase by the olive oil polyphenol hydroxytyrosol in human endothelial cells

Atherosclerosis, 2007-11, Vol.195 (1), p.e58-e64

2007

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Antitumor effects of KITC, a new resveratrol derivative, in AsPC-1 and BxPC-3 human pancreatic carcinoma cells

Investigational new drugs, 2009-10, Vol.27 (5), p.393-401

2009

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Completion of the Spectroscopical Data for the Synthesis of DIMBOA

Scientia pharmaceutica, 2005-09, Vol.73 (3), p.95-100

2005

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Synthesis of Nitrated Thienylphosphonates via Michaelis-Arbuzov-Type Rearrangement

Synthesis (Stuttgart), 2004-04, Vol.2004 (5), p.668-670

2004

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Pharmacophore Generation for Multiple Ligands

Drug Selectivity, 2017, p.275-312

2017

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N-hydroxy-N'-(3,4,5-trimethoxyphenyl)-3,4,5-trimethoxy-benzamidine, a novel resveratrol analog, inhibits ribonucleotide reductase in HL-60 human promyelocytic leukemia cells: synergistic antitumor activity with arabinofuranosylcytosine

International journal of oncology, 2007-11, Vol.31 (5), p.1261

2007

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Drug Selectivity: An Evolving Concept in Medicinal Chemistry

Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity

Synthesis of Novel Curcumin Analogues and Their Evaluation as Selective Cyclooxygenase-1 (COX-1) Inhibitors

The quality of drugs and drug products - Always guaranteed?

Antioxidant activity of resveratrol, piceatannol and 3,3',4,4',5,5'-hexahydroxy-trans-stilbene in three leukemia cell lines

Novel Resveratrol Derivatives Induce Apoptosis and Cause Cell Cycle Arrest in Prostate Cancer Cell Lines

New approaches to treating pain

Ball milling - a new concept for predicting degradation profiles in active pharmaceutical ingredients

Antioxidant, prooxidant and cytotoxic activity of hydroxylated resveratrol analogues: structure–activity relationship

Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure–activity relationship

Mechanochemical Oxidative Degradation of Thienopyridine Containing Drugs: Toward a Simple Tool for the Prediction of Drug Stability

Antiproliferative and Pro-apoptotic Activities of a Novel Resveratrol Prodrug Against Jurkat CD4+ T-Cells

Drug Selectivity

A tetracyclic thiophene trimer synthesis and mechanism of formation

A Novel Genistein Prodrug: Design, Synthesis and Bioactivity on Mouse RAW264.7 Macrophages

‘Bridged’ stilbene derivatives as selective cyclooxygenase-1 inhibitors

Cytotoxic and biochemical effects of 3,3′,4,4′,5,5′-hexahydroxystilbene, a novel resveratrol analog in HL-60 human promyelocytic leukemia cells

Novel resveratrol analogs induce apoptosis and cause cell cycle arrest in HT29 human colon cancer cells : Inhibition of ribonucleotide reductase activity

Benzanilides with spasmolytic activity: Chemistry, pharmacology, and SAR

No evidence for modulation of endothelial nitric oxide synthase by the olive oil polyphenol hydroxytyrosol in human endothelial cells

Antitumor effects of KITC, a new resveratrol derivative, in AsPC-1 and BxPC-3 human pancreatic carcinoma cells

Completion of the Spectroscopical Data for the Synthesis of DIMBOA

Synthesis of Nitrated Thienylphosphonates via Michaelis-Arbuzov-Type Rearrangement

Pharmacophore Generation for Multiple Ligands

N-hydroxy-N'-(3,4,5-trimethoxyphenyl)-3,4,5-trimethoxy-benzamidine, a novel resveratrol analog, inhibits ribonucleotide reductase in HL-60 human promyelocytic leukemia cells: synergistic antitumor activity with arabinofuranosylcytosine

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