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Assembly assay identifies a critical region of human fibrillin-1 required for 10-12 nm diameter microfibril biogenesis

PloS one, 2021-03, Vol.16 (3), p.e0248532-e0248532

2021

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Notch receptor–ligand binding and activation: Insights from molecular studies

Seminars in cell & developmental biology, 2012-06, Vol.23 (4), p.421-428

2012

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Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands

Proceedings of the National Academy of Sciences - PNAS, 2014-05, Vol.111 (20), p.7290-7295

2014

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Dissecting the Fibrillin Microfibril: Structural Insights into Organization and Function

Structure (London), 2012-02, Vol.20 (2), p.215-225

2012

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Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands

The EMBO journal, 2017-08, Vol.36 (15), p.2204-2215

2017

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Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies

Structure (London), 2016-04, Vol.24 (4), p.555-566

2016

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Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern

Nature communications, 2019-10, Vol.10 (1), p.4910-16, Article 4910

2019

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C-terminal propeptide is required for fibrillin-1 secretion and blocks premature assembly through linkage to domains cbEGF41-43

Proceedings of the National Academy of Sciences - PNAS, 2014-07, Vol.111 (28), p.10155-10160

2014

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A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans -activation and cis -inhibition

Nature structural & molecular biology, 2008-08, Vol.15 (8), p.849-857

2008

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NMR spectroscopic and bioinformatic analyses of the LTBP1 C-terminus reveal a highly dynamic domain organisation

PloS one, 2014-01, Vol.9 (1), p.e87125-e87125

2014

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Structure of the Fibrillin-1 N-Terminal Domains Suggests that Heparan Sulfate Regulates the Early Stages of Microfibril Assembly

Structure (London), 2013-10, Vol.21 (10), p.1743-1756

2013

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Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands

Cell reports (Cambridge), 2013-11, Vol.5 (4), p.861-867

2013

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Somatic mutant clones colonize the human esophagus with age

Science (American Association for the Advancement of Science), 2018-11, Vol.362 (6417), p.911-917

2018

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Localization of the Delta-like-1-binding Site in Human Notch-1 and Its Modulation by Calcium Affinity

The Journal of biological chemistry, 2008-04, Vol.283 (17), p.11785-11793

2008

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Two novel protein O-glucosyltransferases that modify sites distinct from POGLUT1 and affect Notch trafficking and signaling

Proceedings of the National Academy of Sciences - PNAS, 2018-09, Vol.115 (36), p.E8395-E8402

2018

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Molecular Basis for Jagged-1/Serrate Ligand Recognition by the Notch Receptor

The Journal of biological chemistry, 2013-03, Vol.288 (10), p.7305-7312

2013

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ELTD1 is present in extracellular vesicles derived from endothelial cells as a cleaved extracellular domain which induces in vivo angiogenesis

Journal of extracellular biology, 2022-08, Vol.1 (8), p.e52-n/a

2022

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New insights into the structure, assembly and biological roles of 10-12 nm connective tissue microfibrils from fibrillin-1 studies

Biochemical journal, 2016-04, Vol.473 (7), p.827-838

2016

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CRB1 mutation spectrum in inherited retinal dystrophies

Human mutation, 2004-11, Vol.24 (5), p.355-369

2004

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Structural and Functional Characterization of a Novel T Cell Receptor Co-regulatory Protein Complex, CD97-CD55

The Journal of biological chemistry, 2007-07, Vol.282 (30), p.22023-22032

2007

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Structural and Functional Properties of the Human Notch-1 Ligand Binding Region

Structure (London), 2004-12, Vol.12 (12), p.2173-2183

2004

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Development of Therapeutic Anti-JAGGED1 Antibodies for Cancer Therapy

Molecular cancer therapeutics, 2019-11, Vol.18 (11), p.2030-2042

2019

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A disease-associated mutation in fibrillin-1 differentially regulates integrin-mediated cell adhesion

The Journal of biological chemistry, 2019-11, Vol.294 (48), p.18232-18243

2019

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The conserved C2 phospholipid‐binding domain in Delta contributes to robust Notch signalling

EMBO reports, 2021-10, Vol.22 (10), p.e52729-n/a

2021

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An N-glycan on the C2 domain of JAGGED1 is important for Notch activation

Science signaling, 2022-10, Vol.15 (755), p.eabo3507

2022

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Assembly assay identifies a critical region of human fibrillin-1 required for 10-12 nm diameter microfibril biogenesis

Notch receptor–ligand binding and activation: Insights from molecular studies

Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands

Dissecting the Fibrillin Microfibril: Structural Insights into Organization and Function

Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands

Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern

C-terminal propeptide is required for fibrillin-1 secretion and blocks premature assembly through linkage to domains cbEGF41-43

A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans -activation and cis -inhibition

NMR spectroscopic and bioinformatic analyses of the LTBP1 C-terminus reveal a highly dynamic domain organisation

Structure of the Fibrillin-1 N-Terminal Domains Suggests that Heparan Sulfate Regulates the Early Stages of Microfibril Assembly

Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands

Somatic mutant clones colonize the human esophagus with age

Localization of the Delta-like-1-binding Site in Human Notch-1 and Its Modulation by Calcium Affinity

Two novel protein O-glucosyltransferases that modify sites distinct from POGLUT1 and affect Notch trafficking and signaling

Molecular Basis for Jagged-1/Serrate Ligand Recognition by the Notch Receptor

ELTD1 is present in extracellular vesicles derived from endothelial cells as a cleaved extracellular domain which induces in vivo angiogenesis

New insights into the structure, assembly and biological roles of 10-12 nm connective tissue microfibrils from fibrillin-1 studies

CRB1 mutation spectrum in inherited retinal dystrophies

Structural and Functional Characterization of a Novel T Cell Receptor Co-regulatory Protein Complex, CD97-CD55

Structural and Functional Properties of the Human Notch-1 Ligand Binding Region

Development of Therapeutic Anti-JAGGED1 Antibodies for Cancer Therapy

A disease-associated mutation in fibrillin-1 differentially regulates integrin-mediated cell adhesion

The conserved C2 phospholipid‐binding domain in Delta contributes to robust Notch signalling

An N-glycan on the C2 domain of JAGGED1 is important for Notch activation

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