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Assembly assay identifies a critical region of human fibrillin-1 required for 10-12 nm diameter microfibril biogenesis

PloS one, 2021-03, Vol.16 (3), p.e0248532-e0248532

2021

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Somatic mutant clones colonize the human esophagus with age

Science (American Association for the Advancement of Science), 2018-11, Vol.362 (6417), p.911-917

2018

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Two novel protein O-glucosyltransferases that modify sites distinct from POGLUT1 and affect Notch trafficking and signaling

Proceedings of the National Academy of Sciences - PNAS, 2018-09, Vol.115 (36), p.E8395-E8402

2018

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Notch receptor–ligand binding and activation: Insights from molecular studies

Seminars in cell & developmental biology, 2012-06, Vol.23 (4), p.421-428

2012

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Dissecting the Fibrillin Microfibril: Structural Insights into Organization and Function

Structure (London), 2012-02, Vol.20 (2), p.215-225

2012

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New insights into the structure, assembly and biological roles of 10-12 nm connective tissue microfibrils from fibrillin-1 studies

Biochemical journal, 2016-04, Vol.473 (7), p.827-838

2016

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Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands

Proceedings of the National Academy of Sciences - PNAS, 2014-05, Vol.111 (20), p.7290-7295

2014

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Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies

Structure (London), 2016-04, Vol.24 (4), p.555-566

2016

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Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern

Nature communications, 2019-10, Vol.10 (1), p.4910-16, Article 4910

2019

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Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands

The EMBO journal, 2017-08, Vol.36 (15), p.2204-2215

2017

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A microfibril assembly assay identifies different mechanisms of dominance underlying Marfan syndrome, stiff skin syndrome and acromelic dysplasias

Human molecular genetics, 2015-08, Vol.24 (15), p.4454-4463

2015

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NMR spectroscopic and bioinformatic analyses of the LTBP1 C-terminus reveal a highly dynamic domain organisation

PloS one, 2014-01, Vol.9 (1), p.e87125-e87125

2014

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C-terminal propeptide is required for fibrillin-1 secretion and blocks premature assembly through linkage to domains cbEGF41-43

Proceedings of the National Academy of Sciences - PNAS, 2014-07, Vol.111 (28), p.10155-10160

2014

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A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans -activation and cis -inhibition

Nature structural & molecular biology, 2008-08, Vol.15 (8), p.849-857

2008

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A form of muscular dystrophy associated with pathogenic variants in JAG2

American journal of human genetics, 2021-06, Vol.108 (6), p.1164-1164

2021

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Development of Therapeutic Anti-JAGGED1 Antibodies for Cancer Therapy

Molecular cancer therapeutics, 2019-11, Vol.18 (11), p.2030-2042

2019

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A disease-associated mutation in fibrillin-1 differentially regulates integrin-mediated cell adhesion

The Journal of biological chemistry, 2019-11, Vol.294 (48), p.18232-18243

2019

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The conserved C2 phospholipid‐binding domain in Delta contributes to robust Notch signalling

EMBO reports, 2021-10, Vol.22 (10), p.e52729-n/a

2021

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Structural Insights into Notch Receptor-Ligand Interactions

Advances in experimental medicine and biology, 2018, Vol.1066, p.33-46

2018

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An N-glycan on the C2 domain of JAGGED1 is important for Notch activation

Science signaling, 2022-10, Vol.15 (755), p.eabo3507

2022

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Structure of the Fibrillin-1 N-Terminal Domains Suggests that Heparan Sulfate Regulates the Early Stages of Microfibril Assembly

Structure (London), 2013-10, Vol.21 (10), p.1743-1756

2013

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Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands

Cell reports (Cambridge), 2013-11, Vol.5 (4), p.861-867

2013

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Mutations in the TGFβ Binding-Protein-Like Domain 5 of FBN1 Are Responsible for Acromicric and Geleophysic Dysplasias

American journal of human genetics, 2011-07, Vol.89 (1), p.7-14

2011

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The N-Terminal Region of Fibrillin-1 Mediates a Bipartite Interaction with LTBP1

Structure (London), 2017-08, Vol.25 (8), p.1208-1221.e5

2017

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A form of muscular dystrophy associated with pathogenic variants in JAG2

American journal of human genetics, 2021-05, Vol.108 (5), p.840-856

2021

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Assembly assay identifies a critical region of human fibrillin-1 required for 10-12 nm diameter microfibril biogenesis

Somatic mutant clones colonize the human esophagus with age

Two novel protein O-glucosyltransferases that modify sites distinct from POGLUT1 and affect Notch trafficking and signaling

Notch receptor–ligand binding and activation: Insights from molecular studies

Dissecting the Fibrillin Microfibril: Structural Insights into Organization and Function

New insights into the structure, assembly and biological roles of 10-12 nm connective tissue microfibrils from fibrillin-1 studies

Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands

Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern

Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands

A microfibril assembly assay identifies different mechanisms of dominance underlying Marfan syndrome, stiff skin syndrome and acromelic dysplasias

NMR spectroscopic and bioinformatic analyses of the LTBP1 C-terminus reveal a highly dynamic domain organisation

C-terminal propeptide is required for fibrillin-1 secretion and blocks premature assembly through linkage to domains cbEGF41-43

A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans -activation and cis -inhibition

A form of muscular dystrophy associated with pathogenic variants in JAG2

Development of Therapeutic Anti-JAGGED1 Antibodies for Cancer Therapy

A disease-associated mutation in fibrillin-1 differentially regulates integrin-mediated cell adhesion

The conserved C2 phospholipid‐binding domain in Delta contributes to robust Notch signalling

Structural Insights into Notch Receptor-Ligand Interactions

An N-glycan on the C2 domain of JAGGED1 is important for Notch activation

Structure of the Fibrillin-1 N-Terminal Domains Suggests that Heparan Sulfate Regulates the Early Stages of Microfibril Assembly

Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands

Mutations in the TGFβ Binding-Protein-Like Domain 5 of FBN1 Are Responsible for Acromicric and Geleophysic Dysplasias

The N-Terminal Region of Fibrillin-1 Mediates a Bipartite Interaction with LTBP1

A form of muscular dystrophy associated with pathogenic variants in JAG2

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