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Boosting NAD + with a small molecule that activates NAMPT

Nature communications, 2019-07, Vol.10 (1), p.3241-12, Article 3241

2019

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Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme

Nature communications, 2018-12, Vol.9 (1), p.5145-12, Article 5145

2018

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Discovery of small molecule guanylyl cyclase A receptor positive allosteric modulators

Proceedings of the National Academy of Sciences - PNAS, 2021-12, Vol.118 (52), p.1

2021

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Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators

Bioorganic & medicinal chemistry letters, 2021-06, Vol.41, p.128007-128007, Article 128007

2021

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Discovery of small molecule antagonists of chemokine receptor CXCR6 that arrest tumor growth in SK-HEP-1 mouse xenografts as a model of hepatocellular carcinoma

Bioorganic & medicinal chemistry letters, 2020-02, Vol.30 (4), p.126899-126899, Article 126899

2020

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Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells

Cancer letters, 2019-05, Vol.449, p.145-162

2019

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Benzimidazole- and benzoxazole-based inhibitors of Rho kinase

Bioorganic & medicinal chemistry, 2008-12, Vol.18 (24), p.6390-6393

2008

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Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I)

Bioorganic & medicinal chemistry letters, 2011-12, Vol.21 (23), p.7107-7112

2011

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Synthesis and biological evaluation of 4-quinazolinones as Rho kinase inhibitors

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (6), p.1844-1848

2011

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Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (Part-II)

Bioorganic & medicinal chemistry letters, 2011-12, Vol.21 (23), p.7113-7118

2011

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The development of benzimidazoles as selective rho kinase inhibitors

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (6), p.1939-1943

2010

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Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition

Bioorganic & medicinal chemistry letters, 2021-07, Vol.43, p.128048-128048, Article 128048

2021

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Measurement of Pyridine Nucleotides in Biological Samples Using LC-MS/MS

Methods in molecular biology (Clifton, N.J.), 2019-01, Vol.1996, p.61

2019

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Discovery of Novel Small-Molecule Inducers of Heme Oxygenase-1 That Protect Human iPSC-Derived Cardiomyocytes from Oxidative Stress

The Journal of pharmacology and experimental therapeutics, 2018-01, Vol.364 (1), p.87-96

2018

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Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors

ACS medicinal chemistry letters, 2017-07, Vol.8 (7), p.726-731

2017

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Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation

ACS medicinal chemistry letters, 2011-10, Vol.2 (10), p.780-785

2011

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Studies on the Synthesis of Furanosteroids. I. Viridin Models

Organic letters, 2006-08, Vol.8 (18), p.4125-4128

2006

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Furanosteroid Studies. Stereoselective Synthesis of the A,B,E-Ring Core of Wortmannin

Organic letters, 2007-08, Vol.9 (17), p.3221-3224

2007

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Studies on Inducers of Nerve Growth Factor: Synthesis of the Cyathin Core

Organic letters, 1999-11, Vol.1 (10), p.1535-1538

1999

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Two-Step Electrochemical Annulation for the Assembly of Polycyclic Systems

Organic letters, 2002-10, Vol.4 (21), p.3763-3765

2002

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Synthetic studies toward the furanosteroids

Sessions, E Hampton

2009

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Design and structural characterization of a bivalent MAP kinase inhibitor

Acta crystallographica. Section A, Foundations and advances, 2017-05, Vol.73 (a1), p.a357-a357

2017

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On the Methylation of Carboxyl Groups with Methanesulfonyl Chloride in Pyridine

Synthetic communications, 2003-01, Vol.33 (15), p.2575-2579

2003

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On the Methylation of Carboxyl Groups with Methanesulfonyl Chloride in Pyridine

ChemInform, 2003-11, Vol.34 (46), p.no-no

2003

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Two-Step Electrochemical Annulation for the Assembly of Polycyclic Systems

ChemInform, 2003-03, Vol.34 (11), p.no-no

2003

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Boosting NAD + with a small molecule that activates NAMPT

Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme

Discovery of small molecule guanylyl cyclase A receptor positive allosteric modulators

Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators

Discovery of small molecule antagonists of chemokine receptor CXCR6 that arrest tumor growth in SK-HEP-1 mouse xenografts as a model of hepatocellular carcinoma

Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells

Benzimidazole- and benzoxazole-based inhibitors of Rho kinase

Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I)

Synthesis and biological evaluation of 4-quinazolinones as Rho kinase inhibitors

Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (Part-II)

The development of benzimidazoles as selective rho kinase inhibitors

Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition

Measurement of Pyridine Nucleotides in Biological Samples Using LC-MS/MS

Discovery of Novel Small-Molecule Inducers of Heme Oxygenase-1 That Protect Human iPSC-Derived Cardiomyocytes from Oxidative Stress

Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors

Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation

Studies on the Synthesis of Furanosteroids. I. Viridin Models

Furanosteroid Studies. Stereoselective Synthesis of the A,B,E-Ring Core of Wortmannin

Studies on Inducers of Nerve Growth Factor: Synthesis of the Cyathin Core

Two-Step Electrochemical Annulation for the Assembly of Polycyclic Systems

Synthetic studies toward the furanosteroids

Design and structural characterization of a bivalent MAP kinase inhibitor

On the Methylation of Carboxyl Groups with Methanesulfonyl Chloride in Pyridine

On the Methylation of Carboxyl Groups with Methanesulfonyl Chloride in Pyridine

Two-Step Electrochemical Annulation for the Assembly of Polycyclic Systems

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