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In vitro studies evaluating the activity of imipenem in combination with relebactam against Pseudomonas aeruginosa

BMC microbiology, 2019-07, Vol.19 (1), p.150-14, Article 150

2019

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Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin

Bioorganic & medicinal chemistry letters, 2014-02, Vol.24 (3), p.780-785

2014

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6H-Benzo[c]chromen-6-one derivatives as selective ERβ agonists

Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (6), p.1468-1472

2006

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Ertapenem: a Group 1 carbapenem with distinct antibacterial and pharmacological properties

Journal of antimicrobial chemotherapy, 2004-06, Vol.53 (suppl-2), p.ii7-ii9

Hammond, Milton L

2004

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Biphenyl-Substituted Oxazolidinones as Cholesteryl Ester Transfer Protein Inhibitors: Modifications of the Oxazolidinone Ring Leading to the Discovery of Anacetrapib

Journal of medicinal chemistry, 2011-07, Vol.54 (13), p.4880-4895

2011

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Synthesis and biological evaluation of platensimycin analogs

Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (6), p.1623-1627

2009

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Discovery of Novel Tricyclic Full Agonists for the G-Protein-Coupled Niacin Receptor 109A with Minimized Flushing in Rats

Journal of medicinal chemistry, 2009-04, Vol.52 (8), p.2587-2602

2009

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Cytochrome P450 3A4-Mediated Bioactivation of Raloxifene: Irreversible Enzyme Inhibition and Thiol Adduct Formation

Chemical research in toxicology, 2002-07, Vol.15 (7), p.907-914

2002

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Discovery of a Biaryl Cyclohexene Carboxylic Acid (MK-6892): A Potent and Selective High Affinity Niacin Receptor Full Agonist with Reduced Flushing Profiles in Animals as a Preclinical Candidate

Journal of medicinal chemistry, 2010-03, Vol.53 (6), p.2666-2670

2010

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Side chain SAR of bicyclic β-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712

Bioorganic & medicinal chemistry letters, 2011-07, Vol.21 (14), p.4267-4270

2011

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2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moiety

Bioorganic & medicinal chemistry letters, 2010, Vol.20 (1), p.346-349

2010

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Side chain SAR of bicyclic β-lactamase inhibitors (BLIs). 1. Discovery of a class C BLI for combination with imipinem

Bioorganic & medicinal chemistry letters, 2010-02, Vol.20 (3), p.918-921

2010

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2-(4-Carbonylphenyl)benzoxazole inhibitors of CETP: Scaffold design and advancement in HDLc-raising efficacy

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (6), p.1890-1895

2011

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2-Arylbenzoxazoles as CETP inhibitors: Raising HDL-C in cynoCETP transgenic mice

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.558-561

2011

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In Vitro Bioactivation of Dihydrobenzoxathiin Selective Estrogen Receptor Modulators by Cytochrome P450 3A4 in Human Liver Microsomes: Formation of Reactive Iminium and Quinone Type Metabolites

Chemical research in toxicology, 2005-04, Vol.18 (4), p.675-685

2005

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Discovery of Biaryl Anthranilides as Full Agonists for the High Affinity Niacin Receptor

Journal of medicinal chemistry, 2007-12, Vol.50 (25), p.6303-6306

2007

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Estrogen Receptor Ligands. II. Discovery of Benzoxathiins as Potent, Selective Estrogen Receptor α Modulators

Journal of medicinal chemistry, 2004-04, Vol.47 (9), p.2171-2175

2004

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Novel N-Arylpyrazolo[3,2-c]-Based Ligands for the Glucocorticoid Receptor: Receptor Binding and in Vivo Activity

Journal of medicinal chemistry, 2004-05, Vol.47 (10), p.2441-2452

2004

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Thiophenyl oxime-derived phosphonates as nano-molar class C beta-lactamase inhibitors reducing MIC of imipenem against Pseudomonas aeruginosa and Acinetobacter baumannii

Bioorganic & medicinal chemistry letters, 2011-07, Vol.21 (14), p.4363-4365

2011

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Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERα

Bioorganic & medicinal chemistry letters, 2007-04, Vol.17 (8), p.2322-2328

2007

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Tetrahydro anthranilic acid as a surrogate for anthranilic acid: Application to the discovery of potent niacin receptor agonists

Bioorganic & medicinal chemistry, 2008-06, Vol.18 (11), p.3163-3167

2008

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Discovery of pyrazolopyrimidines as the first class of allosteric agonists for the high affinity nicotinic acid receptor GPR109A

Bioorganic & medicinal chemistry, 2008-09, Vol.18 (18), p.4948-4951

2008

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SAR studies on the central phenyl ring of substituted biphenyl oxazolidinone-potent CETP inhibitors

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (1), p.199-203

2012

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2-Arylbenzoxazoles as CETP inhibitors: Substitution and modification of the α-alkoxyamide moiety

Bioorganic & medicinal chemistry letters, 2010-02, Vol.20 (3), p.1019-1022

2010

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Design of a novel class of biphenyl CETP inhibitors

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (24), p.7469-7472

2010

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In vitro studies evaluating the activity of imipenem in combination with relebactam against Pseudomonas aeruginosa

Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin

6H-Benzo[c]chromen-6-one derivatives as selective ERβ agonists

Ertapenem: a Group 1 carbapenem with distinct antibacterial and pharmacological properties

Biphenyl-Substituted Oxazolidinones as Cholesteryl Ester Transfer Protein Inhibitors: Modifications of the Oxazolidinone Ring Leading to the Discovery of Anacetrapib

Synthesis and biological evaluation of platensimycin analogs

Discovery of Novel Tricyclic Full Agonists for the G-Protein-Coupled Niacin Receptor 109A with Minimized Flushing in Rats

Cytochrome P450 3A4-Mediated Bioactivation of Raloxifene: Irreversible Enzyme Inhibition and Thiol Adduct Formation

Discovery of a Biaryl Cyclohexene Carboxylic Acid (MK-6892): A Potent and Selective High Affinity Niacin Receptor Full Agonist with Reduced Flushing Profiles in Animals as a Preclinical Candidate

Side chain SAR of bicyclic β-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712

2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moiety

Side chain SAR of bicyclic β-lactamase inhibitors (BLIs). 1. Discovery of a class C BLI for combination with imipinem

2-(4-Carbonylphenyl)benzoxazole inhibitors of CETP: Scaffold design and advancement in HDLc-raising efficacy

2-Arylbenzoxazoles as CETP inhibitors: Raising HDL-C in cynoCETP transgenic mice

In Vitro Bioactivation of Dihydrobenzoxathiin Selective Estrogen Receptor Modulators by Cytochrome P450 3A4 in Human Liver Microsomes: Formation of Reactive Iminium and Quinone Type Metabolites

Discovery of Biaryl Anthranilides as Full Agonists for the High Affinity Niacin Receptor

Estrogen Receptor Ligands. II. Discovery of Benzoxathiins as Potent, Selective Estrogen Receptor α Modulators

Novel N-Arylpyrazolo[3,2-c]-Based Ligands for the Glucocorticoid Receptor: Receptor Binding and in Vivo Activity

Thiophenyl oxime-derived phosphonates as nano-molar class C beta-lactamase inhibitors reducing MIC of imipenem against Pseudomonas aeruginosa and Acinetobacter baumannii

Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERα

Tetrahydro anthranilic acid as a surrogate for anthranilic acid: Application to the discovery of potent niacin receptor agonists

Discovery of pyrazolopyrimidines as the first class of allosteric agonists for the high affinity nicotinic acid receptor GPR109A

SAR studies on the central phenyl ring of substituted biphenyl oxazolidinone-potent CETP inhibitors

2-Arylbenzoxazoles as CETP inhibitors: Substitution and modification of the α-alkoxyamide moiety

Design of a novel class of biphenyl CETP inhibitors

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