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Ultra-High Dose Rate (FLASH) Radiotherapy: Silver Bullet or Fool's Gold?

Frontiers in oncology, 2020-01, Vol.9, p.1563-1563

2020

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Cyclic Hypoxia: An Update on Its Characteristics, Methods to Measure It and Biological Implications in Cancer

Cancers, 2020-12, Vol.13 (1), p.23

2020

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Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity

Nucleic acids research, 2021-07, Vol.49 (13), p.7492-7506

2021

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The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia

Nature communications, 2016-07, Vol.7 (1), p.12308-12308, Article 12308

2016

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Replication Stress Drives Constitutive Activation of the DNA Damage Response and Radioresistance in Glioblastoma Stem-like Cells

Cancer research (Chicago, Ill.), 2018-09, Vol.78 (17), p.5060-5071

2018

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Replication Stress and Chromatin Context Link ATM Activation to a Role in DNA Replication

Molecular cell, 2013-12, Vol.52 (5), p.758-766

2013

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Links between the unfolded protein response and the DNA damage response in hypoxia: a systematic review

Biochemical Society transactions, 2021-06, Vol.49 (3), p.1251-1263

2021

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Challenges to DNA replication in hypoxic conditions

The FEBS journal, 2018-05, Vol.285 (9), p.1563-1571

2018

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Inhibition of CDK4/CDK6 Enhances Radiosensitivity of HPV Negative Head and Neck Squamous Cell Carcinomas

International journal of radiation oncology, biology, physics, 2019-11, Vol.105 (3), p.548-558

2019

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Hypoxia inducible factors regulate hepatitis B virus replication by activating the basal core promoter

Journal of hepatology, 2021-07, Vol.75 (1), p.64-73

2021

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Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor

Cell chemical biology, 2021-09, Vol.28 (9), p.1258-1270.e13

2021

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Contextual Synthetic Lethality of Cancer Cell Kill Based on the Tumor Microenvironment

Cancer research (Chicago, Ill.), 2010-10, Vol.70 (20), p.8045-8054

2010

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Targeting Hypoxic Cells through the DNA Damage Response

Clinical cancer research, 2010-12, Vol.16 (23), p.5624-5629

2010

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UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization

Scientific reports, 2017-07, Vol.7 (1), p.6879-9, Article 6879

2017

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Hypoxia-induced SETX links replication stress with the unfolded protein response

Nature communications, 2021-06, Vol.12 (1), p.3686-14, Article 3686

2021

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Design, synthesis and evaluation of molecularly targeted hypoxia-activated prodrugs

Nature protocols, 2016-04, Vol.11 (4), p.781-794

2016

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Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands

Journal of medicinal chemistry, 2013-04, Vol.56 (8), p.3217-3227

2013

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Effects of Acute versus Chronic Hypoxia on DNA Damage Responses and Genomic Instability

Cancer research (Chicago, Ill.), 2010-02, Vol.70 (3), p.925-935

2010

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Hypoxia‐mediated regulation of DDX5 through decreased chromatin accessibility and post‐translational targeting restricts R‐loop accumulation

Molecular oncology, 2023-07, Vol.17 (7), p.1173-1191

2023

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Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α)

PloS one, 2011-01, Vol.6 (1), p.e16210-e16210

2011

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KDM4A regulates HIF-1 levels through H3K9me3

Scientific reports, 2017-09, Vol.7 (1), p.11094-9, Article 11094

2017

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ATM Activation and Signaling under Hypoxic Conditions

Molecular and Cellular Biology, 2009-01, Vol.29 (2), p.526-537

2009

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A novel method for autophagy detection in primary cells: Impaired levels of macroautophagy in immunosenescent T cells

Autophagy, 2012-04, Vol.8 (4), p.677-689

2012

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ZBTB2 links p53 deficiency to HIF‐1‐mediated hypoxia signaling to promote cancer aggressiveness

EMBO reports, 2023-01, Vol.24 (1), p.e54042-n/a

2023

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Selective modulation by PARP-1 of HIF-1α-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions

Redox biology, 2021-05, Vol.41, p.101885, Article 101885

2021

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Ultra-High Dose Rate (FLASH) Radiotherapy: Silver Bullet or Fool's Gold?

Cyclic Hypoxia: An Update on Its Characteristics, Methods to Measure It and Biological Implications in Cancer

Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity

The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia

Replication Stress Drives Constitutive Activation of the DNA Damage Response and Radioresistance in Glioblastoma Stem-like Cells

Replication Stress and Chromatin Context Link ATM Activation to a Role in DNA Replication

Links between the unfolded protein response and the DNA damage response in hypoxia: a systematic review

Challenges to DNA replication in hypoxic conditions

Inhibition of CDK4/CDK6 Enhances Radiosensitivity of HPV Negative Head and Neck Squamous Cell Carcinomas

Hypoxia inducible factors regulate hepatitis B virus replication by activating the basal core promoter

Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor

Contextual Synthetic Lethality of Cancer Cell Kill Based on the Tumor Microenvironment

Targeting Hypoxic Cells through the DNA Damage Response

UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization

Hypoxia-induced SETX links replication stress with the unfolded protein response

Design, synthesis and evaluation of molecularly targeted hypoxia-activated prodrugs

Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands

Effects of Acute versus Chronic Hypoxia on DNA Damage Responses and Genomic Instability

Hypoxia‐mediated regulation of DDX5 through decreased chromatin accessibility and post‐translational targeting restricts R‐loop accumulation

Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α)

KDM4A regulates HIF-1 levels through H3K9me3

ATM Activation and Signaling under Hypoxic Conditions

A novel method for autophagy detection in primary cells: Impaired levels of macroautophagy in immunosenescent T cells

ZBTB2 links p53 deficiency to HIF‐1‐mediated hypoxia signaling to promote cancer aggressiveness

Selective modulation by PARP-1 of HIF-1α-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions

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