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The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity

Nature communications, 2018-08, Vol.9 (1), p.3049-13, Article 3049

2018

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Metformin-induced reductions in tumor growth involves modulation of the gut microbiome

Molecular metabolism (Germany), 2022-07, Vol.61, p.101498-101498, Article 101498

2022

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Expanded human NK cells armed with CAR uncouple potent anti-tumor activity from off-tumor toxicity against solid tumors

iScience, 2021-06, Vol.24 (6), p.102619-102619, Article 102619

2021

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AMPK β1 reduces tumor progression and improves survival in p53 null mice

Molecular oncology, 2017-09, Vol.11 (9), p.1143-1155

2017

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Manufacturing T cells in hollow fiber membrane bioreactors changes their programming and enhances their potency

Oncoimmunology, 2021-01, Vol.10 (1), p.1995168-1995168

2021

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A Cross-Reactive Small Protein Binding Domain Provides a Model to Study Off-Tumor CAR-T Cell Toxicity

Molecular therapy. Oncolytics, 2020-06, Vol.17, p.278-292

2020

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CD11b + Dendritic Cell-Mediated Anti- Mycobacterium tuberculosis Th1 Activation Is Counterregulated by CD103 + Dendritic Cells via IL-10

The Journal of immunology (1950), 2018-03, Vol.200 (5), p.1746-1760

2018

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T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice

Molecular therapy, 2015-10, Vol.23 (10), p.1600-1610

2015

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T-cell engineered with a fully humanized B-cell maturation antigen-specific T-cell antigen coupler receptor effectively target multiple myeloma

Cytotherapy (Oxford, England), 2023-05, Vol.25 (5), p.490-501

2023

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Expanded CD56superbrightCD16+ NK Cells from Ovarian Cancer Patients Are Cytotoxic against Autologous Tumor in a Patient-Derived Xenograft Murine Model

Cancer immunology research, 2018-10, Vol.6 (10), p.1174-1185

2018

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Viral Engineering of Chimeric Antigen Receptor Expression on Murine and Human T Lymphocytes

Methods in molecular biology (Clifton, N.J.), 2016-01, Vol.1458, p.137

2016

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Designed ankyrin repeat proteins are effective targeting elements for chimeric antigen receptors

Journal for immunotherapy of cancer, 2015-12, Vol.3 (1), p.55-55, Article 55

2015

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Chimeric antigen receptor–engineered T cells as oncolytic virus carriers

Molecular therapy. Oncolytics, 2015, Vol.2, p.15014-15014, Article 15014

2015

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Combined mTOR Inhibition and OX40 Agonism Enhances CD8+ T Cell Memory and Protective Immunity Produced by Recombinant Adenovirus Vaccines

Molecular therapy, 2012-04, Vol.20 (4), p.860-869

2012

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Electrophilic proximity-inducing synthetic adapters enhance universal T cell function by covalently enforcing immune receptor signaling

Molecular Therapy Oncology, 2024-09, Vol.32 (3), p.200842, Article 200842

2024

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Combined mTOR Inhibition and OX40 Agonism Enhances CD8 super(+) T Cell Memory and Protective Immunity Produced by Recombinant Adenovirus Vaccines

Molecular therapy, 2012-04, Vol.20 (4), p.860-869

2012

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Expanded CD56 superbright CD16 + NK Cells from Ovarian Cancer Patients Are Cytotoxic against Autologous Tumor in a Patient-Derived Xenograft Murine Model

Cancer immunology research, 2018-10, Vol.6 (10), p.1174

2018

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Chimeric antigen receptorâengineered T cells as oncolytic virus carriers

Molecular therapy. Oncolytics, 2015-01, Vol.2

2015

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On-target off-tumor toxicity; when enhancing an NKG2D-based CAR in vitro led to severe toxicities in vivo

Journal for immunotherapy of cancer, 2014-11, Vol.2 (Suppl 3), p.P15-P15

2014

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Abstract 1424: Preclinical development of TAC01-CD19, a CD19 specific T-cell Antigen Coupler (TAC) therapy for the treatment of CD19-positive B cell malignancies

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.1424-1424

2019

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T Cells Engineered with T Cell Antigen Coupler (TAC) Receptors for Haematological Malignancies

Blood, 2018-11, Vol.132 (Supplement 1), p.3267-3267

2018

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94 The T cell antigen coupler (TAC) redirects T cell oncolysis while limiting tonic signaling to create a safer engineered T cell product with a higher threshold for activation

Journal for immunotherapy of cancer, 2020-11, Vol.8 (Suppl 3), p.A59-A60

2020

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Utilizing dual-specific CD4+ T cells in combination with oncolytic virotherapy for treatment of cancer (P2118)

The Journal of immunology (1950), 2013-05, Vol.190 (1_Supplement), p.132-132.49

2013

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PD47-06 DISPROPORTIONATE USE OF INPATIENT CARE BY OLDER ADULTS WITH URINARY STONE DISEASE

The Journal of urology, 2016-04, Vol.195 (4), p.e1172-e1172

2016

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261 Evidence for durable anti-tumor responses by TAC-T cells in preclinical models of solid tumors

Journal for immunotherapy of cancer, 2022-11, Vol.10 (Suppl 2), p.A276-A276

2022

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The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity

Metformin-induced reductions in tumor growth involves modulation of the gut microbiome

Expanded human NK cells armed with CAR uncouple potent anti-tumor activity from off-tumor toxicity against solid tumors

AMPK β1 reduces tumor progression and improves survival in p53 null mice

Manufacturing T cells in hollow fiber membrane bioreactors changes their programming and enhances their potency

A Cross-Reactive Small Protein Binding Domain Provides a Model to Study Off-Tumor CAR-T Cell Toxicity

CD11b + Dendritic Cell-Mediated Anti- Mycobacterium tuberculosis Th1 Activation Is Counterregulated by CD103 + Dendritic Cells via IL-10

T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice

T-cell engineered with a fully humanized B-cell maturation antigen-specific T-cell antigen coupler receptor effectively target multiple myeloma

Expanded CD56superbrightCD16+ NK Cells from Ovarian Cancer Patients Are Cytotoxic against Autologous Tumor in a Patient-Derived Xenograft Murine Model

Viral Engineering of Chimeric Antigen Receptor Expression on Murine and Human T Lymphocytes

Designed ankyrin repeat proteins are effective targeting elements for chimeric antigen receptors

Chimeric antigen receptor–engineered T cells as oncolytic virus carriers

Combined mTOR Inhibition and OX40 Agonism Enhances CD8+ T Cell Memory and Protective Immunity Produced by Recombinant Adenovirus Vaccines

Electrophilic proximity-inducing synthetic adapters enhance universal T cell function by covalently enforcing immune receptor signaling

Combined mTOR Inhibition and OX40 Agonism Enhances CD8 super(+) T Cell Memory and Protective Immunity Produced by Recombinant Adenovirus Vaccines

Expanded CD56 superbright CD16 + NK Cells from Ovarian Cancer Patients Are Cytotoxic against Autologous Tumor in a Patient-Derived Xenograft Murine Model

Chimeric antigen receptorâengineered T cells as oncolytic virus carriers

On-target off-tumor toxicity; when enhancing an NKG2D-based CAR in vitro led to severe toxicities in vivo

Abstract 1424: Preclinical development of TAC01-CD19, a CD19 specific T-cell Antigen Coupler (TAC) therapy for the treatment of CD19-positive B cell malignancies

T Cells Engineered with T Cell Antigen Coupler (TAC) Receptors for Haematological Malignancies

94 The T cell antigen coupler (TAC) redirects T cell oncolysis while limiting tonic signaling to create a safer engineered T cell product with a higher threshold for activation

Utilizing dual-specific CD4+ T cells in combination with oncolytic virotherapy for treatment of cancer (P2118)

PD47-06 DISPROPORTIONATE USE OF INPATIENT CARE BY OLDER ADULTS WITH URINARY STONE DISEASE

261 Evidence for durable anti-tumor responses by TAC-T cells in preclinical models of solid tumors

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