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Acetate Dependence of Tumors

Cell, 2014-12, Vol.159 (7), p.1591-1602

2014

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Lin28b Is Sufficient to Drive Liver Cancer and Necessary for Its Maintenance in Murine Models

Cancer cell, 2014-08, Vol.26 (2), p.248-261

2014

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Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice[S]

Journal of lipid research, 2018-03, Vol.59 (3), p.475-487

2018

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Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

Proceedings of the National Academy of Sciences - PNAS, 2008-10, Vol.105 (43), p.16767-16772

2008

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White Fat Progenitor Cells Reside in the Adipose Vasculature

Science (American Association for the Advancement of Science), 2008-10, Vol.322 (5901), p.583-586

2008

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Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase

Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (40), p.16184-16189

2012

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Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed bile duct development and loss of hepatocyte viability; a ribosomopathy-like phenotype that is partially p53-dependent

PLoS genetics, 2023-01, Vol.19 (1), p.e1010595-e1010595

2023

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p53 genes function to restrain mobile elements

Genes & development, 2016-01, Vol.30 (1), p.64-77

2016

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A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice

Science (American Association for the Advancement of Science), 2007-10, Vol.318 (5847), p.71-76

2007

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Acss2/HIF-2 signaling facilitates colon cancer growth and metastasis

PloS one, 2023-03, Vol.18 (3), p.e0282223-e0282223

2023

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Modeling Renal Cell Carcinoma in Mice: Bap1 and Pbrm1 Inactivation Drive Tumor Grade

Cancer discovery, 2017-08, Vol.7 (8), p.900-917

2017

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Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice

Journal of lipid research, 2009-03, Vol.50 (3), p.412-423

2009

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Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis

Proceedings of the National Academy of Sciences - PNAS, 2014-11, Vol.111 (46), p.16538-16543

2014

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LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis

eLife, 2017-11, Vol.6

2017

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Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice

eLife, 2017-02, Vol.6

2017

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Decreased Plasma Cholesterol and Hypersensitivity to Statins in Mice Lacking Pcsk9

Proceedings of the National Academy of Sciences - PNAS, 2005-04, Vol.102 (15), p.5374-5379

2005

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A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling

PloS one, 2019-11, Vol.14 (11), p.e0225105

2019

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Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance[S]

Journal of lipid research, 2014-12, Vol.55 (12), p.2597-2605

2014

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Modulation of Synaptic Plasticity and Memory by Reelin Involves Differential Splicing of the Lipoprotein Receptor Apoer2

Neuron (Cambridge, Mass.), 2005-08, Vol.47 (4), p.567-579

2005

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Disruption of Abcg5 and Abcg8 in Mice Reveals Their Crucial Role in Biliary Cholesterol Secretion

Proceedings of the National Academy of Sciences - PNAS, 2002-12, Vol.99 (25), p.16237-16242

2002

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Nkx2-5 Transactivates the Ets-Related Protein 71 Gene and Specifies an Endothelial/Endocardial Fate in the Developing Embryo

Proceedings of the National Academy of Sciences - PNAS, 2009-01, Vol.106 (3), p.814-819

2009

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Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion

Science (American Association for the Advancement of Science), 2008-09, Vol.321 (5895), p.1507-1510

2008

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An acetate switch regulates stress erythropoiesis

Nature medicine, 2014-09, Vol.20 (9), p.1018-1026

2014

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Molecular Mechanisms of Hepatic Steatosis and Insulin Resistance in the AGPAT2-Deficient Mouse Model of Congenital Generalized Lipodystrophy

Cell metabolism, 2009-02, Vol.9 (2), p.165-176

2009

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Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP

Proceedings of the National Academy of Sciences - PNAS, 2010-10, Vol.107 (40), p.17362-17367

2010

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Acetate Dependence of Tumors

Lin28b Is Sufficient to Drive Liver Cancer and Necessary for Its Maintenance in Murine Models

Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice[S]

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

White Fat Progenitor Cells Reside in the Adipose Vasculature

Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase

Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed bile duct development and loss of hepatocyte viability; a ribosomopathy-like phenotype that is partially p53-dependent

p53 genes function to restrain mobile elements

A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice

Acss2/HIF-2 signaling facilitates colon cancer growth and metastasis

Modeling Renal Cell Carcinoma in Mice: Bap1 and Pbrm1 Inactivation Drive Tumor Grade

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice

Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis

LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis

Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice

Decreased Plasma Cholesterol and Hypersensitivity to Statins in Mice Lacking Pcsk9

A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling

Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance[S]

Modulation of Synaptic Plasticity and Memory by Reelin Involves Differential Splicing of the Lipoprotein Receptor Apoer2

Disruption of Abcg5 and Abcg8 in Mice Reveals Their Crucial Role in Biliary Cholesterol Secretion

Nkx2-5 Transactivates the Ets-Related Protein 71 Gene and Specifies an Endothelial/Endocardial Fate in the Developing Embryo

Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion

An acetate switch regulates stress erythropoiesis

Molecular Mechanisms of Hepatic Steatosis and Insulin Resistance in the AGPAT2-Deficient Mouse Model of Congenital Generalized Lipodystrophy

Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP

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