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Understanding the Blood‐Brain Barrier and Beyond: Challenges and Opportunities for Novel CNS Therapeutics

Clinical pharmacology and therapeutics, 2022-04, Vol.111 (4), p.758-773

2022

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Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood–brain barrier

Molecular psychiatry, 2021-12, Vol.26 (12), p.7732-7745

2021

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Rate and extent of mitragynine and 7‐hydroxymitragynine blood–brain barrier transport and their intra‐brain distribution: the missing link in pharmacodynamic studies

Addiction biology, 2019-09, Vol.24 (5), p.935-945

2019

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Oxymorphone Active Uptake at the Blood–Brain Barrier and Population Modeling of its Pharmacokinetic–Pharmacodynamic Relationship

Journal of pharmaceutical sciences, 2013-09, Vol.102 (9), p.3320-3331

2013

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Active‐Site Concentrations of Chemicals – Are They a Better Predictor of Effect than Plasma/Organ/Tissue Concentrations?

Basic & clinical pharmacology & toxicology, 2010-03, Vol.106 (3), p.215-220

Hammarlund‐Udenaes, Margareta

2010

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On The Rate and Extent of Drug Delivery to the Brain

Pharmaceutical research, 2008-08, Vol.25 (8), p.1737-1750

2008

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Effects of pharmacists' interventions on appropriateness of prescribing and evaluation of the instruments' (MAI, STOPP and STARTs') ability to predict hospitalization--analyses from a randomized controlled trial

PloS one, 2013-05, Vol.8 (5), p.e62401

2013

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Structure−Brain Exposure Relationships in Rat and Human Using a Novel Data Set of Unbound Drug Concentrations in Brain Interstitial and Cerebrospinal Fluids

Journal of medicinal chemistry, 2009-10, Vol.52 (20), p.6233-6243

2009

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Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport

Drug metabolism and disposition, 2009-03, Vol.37 (3), p.635-643

2009

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On-line desalting and determination of morphine, morphine-3-glucuronide and morphine-6-glucuronide in microdialysis and plasma samples using column switching and liquid chromatography/tandem mass spectrometry

Rapid communications in mass spectrometry, 2005-01, Vol.19 (15), p.2116-2122

2005

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Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods

Drug metabolism and disposition, 2011-03, Vol.39 (3), p.353-362

2011

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In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids

Drug metabolism and disposition, 2007-09, Vol.35 (9), p.1711-1719

2007

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Pharmacokinetics of P‐glycoprotein inhibition in the rat blood‐brain barrier

Journal of pharmaceutical sciences, 2008-12, Vol.97 (12), p.5386-5400

2008

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The Use of a Deuterated Calibrator for In Vivo Recovery Estimations in Microdialysis Studies

Journal of pharmaceutical sciences, 2008-08, Vol.97 (8), p.3433-3441

2008

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Oxycodone Pharmacokinetics and Pharmacodynamics in the Rat in the Presence of the P-Glycoprotein Inhibitor PSC833

Journal of pharmaceutical sciences, 2005-05, Vol.94 (5), p.1060-1066

2005

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Active CNS delivery of oxycodone in healthy and endotoxemic pigs

Fluids and barriers of the CNS, 2024-10, Vol.21 (1), p.86-15, Article 86

2024

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Improved method for quantitative analysis of the cyclotide kalata B1 in plasma and brain homogenate

Biopolymers, 2016-11, Vol.106 (6), p.910-916

2016

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Mechanistic Study on the Use of the l‑Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets

Molecular pharmaceutics, 2019-07, Vol.16 (7), p.3261-3274

2019

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The role of P‐glycoprotein in blood‐brain barrier transport of morphine: transcortical microdialysis studies in mdr1a (−/−) and mdr1a (+/+) mice

British journal of pharmacology, 1999-10, Vol.128 (3), p.563-568

1999

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Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy

Fluids and barriers of the CNS, 2024-02, Vol.21 (1), p.13-13, Article 13

2024

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Improved measurement of drug exposure in the brain using drug-specific correction for residual blood

Journal of cerebral blood flow and metabolism, 2010-01, Vol.30 (1), p.150-161

2010

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Involvement of the pyrilamine transporter, a putative organic cation transporter, in blood-brain barrier transport of oxycodone

Drug metabolism and disposition, 2008-10, Vol.36 (10), p.2005-2013

2008

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Diphenhydramine Active Uptake at the Blood–Brain Barrier and Its Interaction with Oxycodone in vitro and in Vivo

Journal of pharmaceutical sciences, 2011-09, Vol.100 (9), p.3912-3923

2011

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Molecular Properties Determining Unbound Intracellular and Extracellular Brain Exposure of CNS Drug Candidates

Molecular pharmaceutics, 2015-02, Vol.12 (2), p.520-532

2015

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Validation of a P-Glycoprotein (P-gp) Humanized Mouse Model by Integrating Selective Absolute Quantification of Human MDR1, Mouse Mdr1a and Mdr1b Protein Expressions with In Vivo Functional Analysis for Blood-Brain Barrier Transport

PloS one, 2015-05, Vol.10 (5), p.e0118638-e0118638

2015

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Understanding the Blood‐Brain Barrier and Beyond: Challenges and Opportunities for Novel CNS Therapeutics

Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood–brain barrier

Rate and extent of mitragynine and 7‐hydroxymitragynine blood–brain barrier transport and their intra‐brain distribution: the missing link in pharmacodynamic studies

Oxymorphone Active Uptake at the Blood–Brain Barrier and Population Modeling of its Pharmacokinetic–Pharmacodynamic Relationship

Active‐Site Concentrations of Chemicals – Are They a Better Predictor of Effect than Plasma/Organ/Tissue Concentrations?

On The Rate and Extent of Drug Delivery to the Brain

Effects of pharmacists' interventions on appropriateness of prescribing and evaluation of the instruments' (MAI, STOPP and STARTs') ability to predict hospitalization--analyses from a randomized controlled trial

Structure−Brain Exposure Relationships in Rat and Human Using a Novel Data Set of Unbound Drug Concentrations in Brain Interstitial and Cerebrospinal Fluids

Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport

On-line desalting and determination of morphine, morphine-3-glucuronide and morphine-6-glucuronide in microdialysis and plasma samples using column switching and liquid chromatography/tandem mass spectrometry

Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods

In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids

Pharmacokinetics of P‐glycoprotein inhibition in the rat blood‐brain barrier

The Use of a Deuterated Calibrator for In Vivo Recovery Estimations in Microdialysis Studies

Oxycodone Pharmacokinetics and Pharmacodynamics in the Rat in the Presence of the P-Glycoprotein Inhibitor PSC833

Active CNS delivery of oxycodone in healthy and endotoxemic pigs

Improved method for quantitative analysis of the cyclotide kalata B1 in plasma and brain homogenate

Mechanistic Study on the Use of the l‑Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets

The role of P‐glycoprotein in blood‐brain barrier transport of morphine: transcortical microdialysis studies in mdr1a (−/−) and mdr1a (+/+) mice

Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy

Improved measurement of drug exposure in the brain using drug-specific correction for residual blood

Involvement of the pyrilamine transporter, a putative organic cation transporter, in blood-brain barrier transport of oxycodone

Diphenhydramine Active Uptake at the Blood–Brain Barrier and Its Interaction with Oxycodone in vitro and in Vivo

Molecular Properties Determining Unbound Intracellular and Extracellular Brain Exposure of CNS Drug Candidates

Validation of a P-Glycoprotein (P-gp) Humanized Mouse Model by Integrating Selective Absolute Quantification of Human MDR1, Mouse Mdr1a and Mdr1b Protein Expressions with In Vivo Functional Analysis for Blood-Brain Barrier Transport

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