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Interleukin‐6: Structure‐function relationships

Protein science, 1997-05, Vol.6 (5), p.929-955

1997

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High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130

The Journal of biological chemistry, 1994-09, Vol.269 (37), p.23286-23289

1994

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Differential expression and effects of gp130 cytokines and receptors in prostate cancer cells

The international journal of biochemistry & cell biology, 2004-11, Vol.36 (11), p.2258-2269

2004

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Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types

The EMBO journal, 1988-05, Vol.7 (5), p.1387-1393

1988

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Differential effects of the various isoforms of platelet-derived growth factor on chemotaxis of fibroblasts, monocytes, and granulocytes

The Journal of clinical investigation, 1990-03, Vol.85 (3), p.916-920

1990

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A major part of platelet-derived growth factor purified from human platelets is a heterodimer of one A and one B chain

The Journal of biological chemistry, 1988-11, Vol.263 (31), p.16493-16498

1988

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Identification and structural analysis of the A type receptor for platelet-derived growth factor. Similarities with the B type receptor

The Journal of biological chemistry, 1989-01, Vol.264 (3), p.1742-1747

1989

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Structure‐Function analysis of human IL‐6: Identification of two distinct regions that are important for receptor binding

Protein science, 1994-12, Vol.3 (12), p.2280-2293

1994

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Isoform‐specific induction of actin reorganization by platelet‐derived growth factor suggests that the functionally active receptor is a dimer

The EMBO journal, 1989-09, Vol.8 (9), p.2489-2495

1989

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Interleukin-6 is a potent inducer of S100P, which is up-regulated in androgen-refractory and metastatic prostate cancer

The international journal of biochemistry & cell biology, 2005-02, Vol.37 (2), p.442-450

2005

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Aberrant Expression of Receptors for Platelet-Derived Growth Factor in an Anaplastic Thyroid Carcinoma Cell Line

Proceedings of the National Academy of Sciences - PNAS, 1988-12, Vol.85 (23), p.9302-9306

1988

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Synthesis and assembly of a functionally active recombinant platelet-derived growth factor AB heterodimer

The Journal of biological chemistry, 1988-11, Vol.263 (31), p.16202-16208

1988

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Human malignant mesothelioma cell lines express PDGF β-receptors whereas cultured normal mesothelial cells express predominantly PDGF α-receptors

Oncogene, 1991-11, Vol.6 (11), p.2005-2011

1991

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A major site of expression of the ets transcription factor Elf5 is epithelia of exocrine glands

Histochemistry and cell biology, 2004-12, Vol.122 (6), p.521-526

2004

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Expression of recombinant platelet-derived growth factor A- and B-chain homodimers in rat-1 cells and human fibroblasts reveals differences in protein processing and autocrine effects

Molecular and Cellular Biology, 1988-07, Vol.8 (7), p.2753-2762

1988

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Rsr1 and Rap1 GTPases are activated by the same GTPase-activating protein and require threonine 65 for their activation

The Journal of biological chemistry, 1991-09, Vol.266 (26), p.16992-16995

1991

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Cultured human endothelial cells express platelet-derived growth factor A chain

The American journal of pathology, 1987-01, Vol.126 (1), p.7-12

1987

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Constitutive activation of gp130 leads to neuroendocrine differentiation in vitro and in vivo

The Prostate, 2005-02, Vol.62 (3), p.282-289

2005

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An unexpected biochemical and functional interaction between gp130 and the EGF receptor family in breast cancer cells

Oncogene, 2002-01, Vol.21 (3), p.460-474

2002

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Role of the C‐terminus in the activity, conformation, and stability of interleukin‐6

Protein science, 1993-09, Vol.2 (9), p.1472-1481

1993

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The purification of a Rap1 GTPase-activating protein from bovine brain cytosol

The Journal of biological chemistry, 1992-01, Vol.267 (3), p.1546-1553

1992

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Structural and Biological Characterization of Murine-Human Interleukin-6 Chimeras

Annals of the New York Academy of Sciences, 1995-07, Vol.762 (1), p.422-423

1995

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Stoichiometry of the Interleukin-6 High Affinity Receptor Complex

Annals of the New York Academy of Sciences, 1995-07, Vol.762 (1), p.471-473

1995

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The Immunoglobulin-like Module of gp130 Is Required for Signaling by Interleukin-6, but Not by Leukemia Inhibitory Factor

The Journal of biological chemistry, 1998-08, Vol.273 (35), p.22701-22707

1998

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The A-type receptor for platelet-derived growth factor mediates protein tyrosine phosphorylation, receptor transmodulation and a mitogenic response

Biochemical journal, 1989-11, Vol.264 (1), p.15-20

1989

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Interleukin‐6: Structure‐function relationships

High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130

Differential expression and effects of gp130 cytokines and receptors in prostate cancer cells

Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types

Differential effects of the various isoforms of platelet-derived growth factor on chemotaxis of fibroblasts, monocytes, and granulocytes

A major part of platelet-derived growth factor purified from human platelets is a heterodimer of one A and one B chain

Identification and structural analysis of the A type receptor for platelet-derived growth factor. Similarities with the B type receptor

Structure‐Function analysis of human IL‐6: Identification of two distinct regions that are important for receptor binding

Isoform‐specific induction of actin reorganization by platelet‐derived growth factor suggests that the functionally active receptor is a dimer

Interleukin-6 is a potent inducer of S100P, which is up-regulated in androgen-refractory and metastatic prostate cancer

Aberrant Expression of Receptors for Platelet-Derived Growth Factor in an Anaplastic Thyroid Carcinoma Cell Line

Synthesis and assembly of a functionally active recombinant platelet-derived growth factor AB heterodimer

Human malignant mesothelioma cell lines express PDGF β-receptors whereas cultured normal mesothelial cells express predominantly PDGF α-receptors

A major site of expression of the ets transcription factor Elf5 is epithelia of exocrine glands

Expression of recombinant platelet-derived growth factor A- and B-chain homodimers in rat-1 cells and human fibroblasts reveals differences in protein processing and autocrine effects

Rsr1 and Rap1 GTPases are activated by the same GTPase-activating protein and require threonine 65 for their activation

Cultured human endothelial cells express platelet-derived growth factor A chain

Constitutive activation of gp130 leads to neuroendocrine differentiation in vitro and in vivo

An unexpected biochemical and functional interaction between gp130 and the EGF receptor family in breast cancer cells

Role of the C‐terminus in the activity, conformation, and stability of interleukin‐6

The purification of a Rap1 GTPase-activating protein from bovine brain cytosol

Structural and Biological Characterization of Murine-Human Interleukin-6 Chimeras

Stoichiometry of the Interleukin-6 High Affinity Receptor Complex

The Immunoglobulin-like Module of gp130 Is Required for Signaling by Interleukin-6, but Not by Leukemia Inhibitory Factor

The A-type receptor for platelet-derived growth factor mediates protein tyrosine phosphorylation, receptor transmodulation and a mitogenic response

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