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Relationships between protein degradation, cellular senescence, and organismal aging

Journal of biochemistry (Tokyo), 2024-04, Vol.175 (5), p.473

2024

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ER-Resident Transcription Factor Nrf1 Regulates Proteasome Expression and Beyond

International journal of molecular sciences, 2020-05, Vol.21 (10), p.3683

2020

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Transcriptional regulation of the 26S proteasome by Nrf1

Proceedings of the Japan Academy, Series B, 2018/10/11, Vol.94(8), pp.325-336

2018

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The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction

eLife, 2016-08, Vol.5

2016

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Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis

PLoS genetics, 2015-07, Vol.11 (7), p.e1005401-e1005401

2015

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Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice

Cell, 2007-12, Vol.131 (6), p.1149-1163

2007

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Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process

Molecular and Cellular Biology, 2009-02, Vol.29 (4), p.1095-1106

2009

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A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans

The Journal of clinical investigation, 2011-10, Vol.121 (10), p.4150-4160

2011

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Intrinsic signaling pathways modulate targeted protein degradation

Nature communications, 2024-07, Vol.15 (1), p.5379-14, Article 5379

2024

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NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma Protein

Molecular and cellular biology, 2020-04, Vol.40 (10), p.1-19

2020

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Assembly Pathway of the Mammalian Proteasome Base Subcomplex Is Mediated by Multiple Specific Chaperones

Cell, 2009-05, Vol.137 (5), p.914-925

2009

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Specific Modification of Aged Proteasomes Revealed by Tag-Exchangeable Knock-In Mice

Molecular and cellular biology, 2019-01, Vol.39 (1)

2019

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Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets

Nature communications, 2017-06, Vol.8 (1), p.15540-15540, Article 15540

2017

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Senescent cells form nuclear foci that contain the 26S proteasome

Cell reports (Cambridge), 2023-08, Vol.42 (8), p.112880-112880, Article 112880

2023

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Foxn1-β5t transcriptional axis controls CD8 + T-cell production in the thymus

Nature communications, 2017-02, Vol.8 (1), p.14419-14419, Article 14419

2017

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A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes

The EMBO journal, 2006-10, Vol.25 (19), p.4524-4536

2006

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PAC1 Deficiency Protects Obese Male Mice From Immobilization-Induced Muscle Atrophy by Suppressing FoxO–Atrogene Axis

Endocrinology (Philadelphia), 2023-04, Vol.164 (6), p.1

2023

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Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells

Cell reports (Cambridge), 2019-11, Vol.29 (9), p.2901-2916.e6

2019

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PAC1‐PAC2 proteasome assembly chaperone retains the core α4–α7 assembly intermediates in the cytoplasm

Genes to cells : devoted to molecular & cellular mechanisms, 2018-10, Vol.23 (10), p.839-848

2018

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Sirt1-deficiency causes defective protein quality control

Scientific reports, 2015-07, Vol.5 (1), p.12613-12613, Article 12613

2015

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FAM48A mediates compensatory autophagy induced by proteasome impairment

Genes to cells : devoted to molecular & cellular mechanisms, 2019-08, Vol.24 (8), p.559-568

2019

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Rpn10-Mediated Degradation of Ubiquitinated Proteins Is Essential for Mouse Development

Molecular and Cellular Biology, 2007-10, Vol.27 (19), p.6629-6638

2007

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PAC1 Gene Knockout Reveals an Essential Role of Chaperone-Mediated 20S Proteasome Biogenesis and Latent 20S Proteasomes in Cellular Homeostasis

Molecular and Cellular Biology, 2010-08, Vol.30 (15), p.3864-3874

2010

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Crystal structure of the de-ubiquitinating enzyme UCH37 (human UCH-L5) catalytic domain

Biochemical and biophysical research communications, 2009-12, Vol.390 (3), p.855-860

2009

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Enhanced O-GlcNAcylation Mediates Cytoprotection under Proteasome Impairment by Promoting Proteasome Turnover in Cancer Cells

iScience, 2020-07, Vol.23 (7), p.101299-101299, Article 101299

2020

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Relationships between protein degradation, cellular senescence, and organismal aging

ER-Resident Transcription Factor Nrf1 Regulates Proteasome Expression and Beyond

Transcriptional regulation of the 26S proteasome by Nrf1

The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction

Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis

Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice

Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process

A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans

Intrinsic signaling pathways modulate targeted protein degradation

NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma Protein

Assembly Pathway of the Mammalian Proteasome Base Subcomplex Is Mediated by Multiple Specific Chaperones

Specific Modification of Aged Proteasomes Revealed by Tag-Exchangeable Knock-In Mice

Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets

Senescent cells form nuclear foci that contain the 26S proteasome

Foxn1-β5t transcriptional axis controls CD8 + T-cell production in the thymus

A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes

PAC1 Deficiency Protects Obese Male Mice From Immobilization-Induced Muscle Atrophy by Suppressing FoxO–Atrogene Axis

Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells

PAC1‐PAC2 proteasome assembly chaperone retains the core α4–α7 assembly intermediates in the cytoplasm

Sirt1-deficiency causes defective protein quality control

FAM48A mediates compensatory autophagy induced by proteasome impairment

Rpn10-Mediated Degradation of Ubiquitinated Proteins Is Essential for Mouse Development

PAC1 Gene Knockout Reveals an Essential Role of Chaperone-Mediated 20S Proteasome Biogenesis and Latent 20S Proteasomes in Cellular Homeostasis

Crystal structure of the de-ubiquitinating enzyme UCH37 (human UCH-L5) catalytic domain

Enhanced O-GlcNAcylation Mediates Cytoprotection under Proteasome Impairment by Promoting Proteasome Turnover in Cancer Cells

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