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Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins

Proceedings of the National Academy of Sciences - PNAS, 2013-03, Vol.110 (13), p.E1203-E1211

2013

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Pivotal role of P450-P450 interactions in CYP3A4 allostery: the case of α-naphthoflavone

Biochemical journal, 2013-07, Vol.453 (2), p.219-230

2013

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Conformational Mobility in Cytochrome P450 3A4 Explored by Pressure-Perturbation EPR Spectroscopy

Biophysical journal, 2016-04, Vol.110 (7), p.1485-1498

2016

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Crystal Structure of CYP2B6 in Complex with an Efavirenz Analog

International journal of molecular sciences, 2018-03, Vol.19 (4), p.1025

2018

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Allosteric P450 mechanisms: multiple binding sites, multiple conformers or both?

Expert opinion on drug metabolism & toxicology, 2008-12, Vol.4 (12), p.1523-1535

2008

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Role of cytochrome P450 2B sequence variation and gene copy number in facilitating dietary specialization in mammalian herbivores

Molecular ecology, 2018-02, Vol.27 (3), p.723-736

2018

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Concurrent Cooperativity and Substrate Inhibition in the Epoxidation of Carbamazepine by Cytochrome P450 3A4 Active Site Mutants Inspired by Molecular Dynamics Simulations

Biochemistry (Easton), 2015-01, Vol.54 (3), p.711-721

2015

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Conformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed upon Binding Multiple Amlodipine Molecules

Biochemistry (Easton), 2012-09, Vol.51 (37), p.7225-7238

2012

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Plasticity of CYP2B enzymes: structural and solution biophysical methods

Current drug metabolism, 2012-02, Vol.13 (2), p.167-176

2012

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So many roads traveled: A career in science and administration

The Journal of biological chemistry, 2020-01, Vol.295 (3), p.822-832

Halpert, James R

2020

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The Structural Basis for Homotropic and Heterotropic Cooperativity of Midazolam Metabolism by Human Cytochrome P450 3A4

Biochemistry (Easton), 2011-12, Vol.50 (50), p.10804-10818

2011

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An Open Conformation of Mammalian Cytochrome P450 2B4 at 1.6-Å Resolution

Proceedings of the National Academy of Sciences - PNAS, 2003-11, Vol.100 (23), p.13196-13201

2003

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A large-scale allosteric transition in cytochrome P450 3A4 revealed by luminescence resonance energy transfer (LRET)

PloS one, 2013-12, Vol.8 (12), p.e83898

2013

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Structure-Function Analysis of Mammalian CYP2B Enzymes Using 7-Substituted Coumarin Derivatives as Probes: Utility of Crystal Structures and Molecular Modeling in Understanding Xenobiotic Metabolism

Molecular pharmacology, 2016-04, Vol.89 (4), p.435-445

2016

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Structure–function analysis of cytochromes P450 2B

Biochimica et biophysica acta, 2007-03, Vol.1770 (3), p.402-412

2007

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Cytochrome P450 2B diversity in a dietary specialist—the red tree vole (Arborimus longicaudus)

Journal of mammalogy, 2018-06, Vol.99 (3), p.578-585

2018

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Stereoselective Formation and Metabolism of 4-Hydroxy-Retinoic Acid Enantiomers by Cytochrome P450 Enzymes

The Journal of biological chemistry, 2012-12, Vol.287 (50), p.42223-42232

2012

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Investigation by site‐directed mutagenesis of the role of cytochrome P450 2B4 non‐active‐site residues in protein–ligand interactions based on crystal structures of the ligand‐bound enzyme

The FEBS journal, 2012-05, Vol.279 (9), p.1607-1620

2012

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Decreased susceptibility of the cytochrome P450 2B6 variant K262R to inhibition by several clinically important drugs

Drug metabolism and disposition, 2009-03, Vol.37 (3), p.644-650

2009

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Engineering of cytochrome P450 3A4 for enhanced peroxide-mediated substrate oxidation using directed evolution and site-directed mutagenesis

Drug metabolism and disposition, 2006-12, Vol.34 (12), p.1958-1965

2006

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Analysis of Human Cytochrome P450 3A4 Cooperativity: Construction and Characterization of a Site-Directed Mutant that Displays Hyperbolic Steroid Hydroxylation Kinetics

Proceedings of the National Academy of Sciences - PNAS, 1998-06, Vol.95 (12), p.6636-6641

1998

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Possible pathway(s) of metyrapone egress from the active site of cytochrome P450 3A4: a molecular dynamics simulation

Drug metabolism and disposition, 2007-04, Vol.35 (4), p.689-696

2007

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Interactions among cytochromes P450 in microsomal membranes: oligomerization of cytochromes P450 3A4, 3A5, and 2E1 and its functional consequences

The Journal of biological chemistry, 2015-02, Vol.290 (6), p.3850-3864

2015

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Resolution of Multiple Substrate Binding Sites in Cytochrome P450 3A4: The Stoichiometry of the Enzyme−Substrate Complexes Probed by FRET and Job's Titration

Biochemistry (Easton), 2006-04, Vol.45 (13), p.4199-4209

2006

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Comparison of in vitro metabolism of ticlopidine by human cytochrome P450 2B6 and rabbit cytochrome P450 2B4

Drug metabolism and disposition, 2011-03, Vol.39 (3), p.539-550

2011

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Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins

Pivotal role of P450-P450 interactions in CYP3A4 allostery: the case of α-naphthoflavone

Conformational Mobility in Cytochrome P450 3A4 Explored by Pressure-Perturbation EPR Spectroscopy

Crystal Structure of CYP2B6 in Complex with an Efavirenz Analog

Allosteric P450 mechanisms: multiple binding sites, multiple conformers or both?

Role of cytochrome P450 2B sequence variation and gene copy number in facilitating dietary specialization in mammalian herbivores

Concurrent Cooperativity and Substrate Inhibition in the Epoxidation of Carbamazepine by Cytochrome P450 3A4 Active Site Mutants Inspired by Molecular Dynamics Simulations

Conformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed upon Binding Multiple Amlodipine Molecules

Plasticity of CYP2B enzymes: structural and solution biophysical methods

So many roads traveled: A career in science and administration

The Structural Basis for Homotropic and Heterotropic Cooperativity of Midazolam Metabolism by Human Cytochrome P450 3A4

An Open Conformation of Mammalian Cytochrome P450 2B4 at 1.6-Å Resolution

A large-scale allosteric transition in cytochrome P450 3A4 revealed by luminescence resonance energy transfer (LRET)

Structure-Function Analysis of Mammalian CYP2B Enzymes Using 7-Substituted Coumarin Derivatives as Probes: Utility of Crystal Structures and Molecular Modeling in Understanding Xenobiotic Metabolism

Structure–function analysis of cytochromes P450 2B

Cytochrome P450 2B diversity in a dietary specialist—the red tree vole (Arborimus longicaudus)

Stereoselective Formation and Metabolism of 4-Hydroxy-Retinoic Acid Enantiomers by Cytochrome P450 Enzymes

Investigation by site‐directed mutagenesis of the role of cytochrome P450 2B4 non‐active‐site residues in protein–ligand interactions based on crystal structures of the ligand‐bound enzyme

Decreased susceptibility of the cytochrome P450 2B6 variant K262R to inhibition by several clinically important drugs

Engineering of cytochrome P450 3A4 for enhanced peroxide-mediated substrate oxidation using directed evolution and site-directed mutagenesis

Analysis of Human Cytochrome P450 3A4 Cooperativity: Construction and Characterization of a Site-Directed Mutant that Displays Hyperbolic Steroid Hydroxylation Kinetics

Possible pathway(s) of metyrapone egress from the active site of cytochrome P450 3A4: a molecular dynamics simulation

Interactions among cytochromes P450 in microsomal membranes: oligomerization of cytochromes P450 3A4, 3A5, and 2E1 and its functional consequences

Resolution of Multiple Substrate Binding Sites in Cytochrome P450 3A4: The Stoichiometry of the Enzyme−Substrate Complexes Probed by FRET and Job's Titration

Comparison of in vitro metabolism of ticlopidine by human cytochrome P450 2B6 and rabbit cytochrome P450 2B4

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