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Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists

Science signaling, 2020-03, Vol.13 (625)

2020

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The application of targeted protein degradation technologies to G protein‐coupled receptors

British journal of pharmacology, 2024-07, Vol.181 (14), p.2351-2358

2024

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Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

Proceedings of the National Academy of Sciences - PNAS, 2017-11, Vol.114 (46), p.12309-12314

2017

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Compartmentalization of GPCR signalling controls unique cellular responses

Biochemical Society transactions, 2016-04, Vol.44 (2), p.562-567

2016

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International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1-4, the receptors for relaxin family peptides

Pharmacological reviews, 2015-04, Vol.67 (2), p.389-440

2015

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Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

Nature communications, 2017-07, Vol.8 (1), p.69-69, Article 69

2017

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Illuminating GPCR trafficking

Nature chemical biology, 2024-09

Halls, Michelle L.

2024

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Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations

Science signaling, 2018-10, Vol.11 (551)

2018

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The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells

The Journal of biological chemistry, 2015-08, Vol.290 (34), p.20827-20840

2015

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The complexity of signalling mediated by the glucagon-like peptide-1 receptor

Biochemical Society transactions, 2016-04, Vol.44 (2), p.582-588

2016

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Inhibition of the Proliferation of Human Lung Fibroblasts by Prostacyclin Receptor Agonists is Linked to a Sustained cAMP Signal in the Nucleus

Frontiers in pharmacology, 2021-04, Vol.12, p.669227-669227

2021

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Editorial: Recent Advances in G Protein-Coupled Receptor Signalling: Impact of Intracellular Location, Environment and Biased Agonism

Frontiers in pharmacology, 2021-05, Vol.12, p.707393-707393

2021

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Localised GPCR signalling as revealed by FRET biosensors

Current opinion in cell biology, 2019-04, Vol.57, p.48-56

Halls, Michelle L

2019

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Signal transduction pathways activated by insulin‐like peptide 5 at the relaxin family peptide RXFP4 receptor

British journal of pharmacology, 2017-05, Vol.174 (10), p.1077-1089

2017

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GRK Mediates μ-Opioid Receptor Plasma Membrane Reorganization

Frontiers in molecular neuroscience, 2019-05, Vol.12, p.104

2019

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Genetically Encoded FRET Biosensors to Illuminate Compartmentalised GPCR Signalling

Trends in pharmacological sciences (Regular ed.), 2018-02, Vol.39 (2), p.148-157

2018

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Relaxin Family Peptide Receptors RXFP1 and RXFP2 Modulate cAMP Signaling by Distinct Mechanisms

Molecular pharmacology, 2006-07, Vol.70 (1), p.214-226

2006

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Adenylyl cyclase signalling complexes - Pharmacological challenges and opportunities

Pharmacology & therapeutics (Oxford), 2017-04, Vol.172, p.171-180

2017

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Signalling in response to sub‐picomolar concentrations of active compounds: Pushing the boundaries of GPCR sensitivity

British journal of pharmacology, 2019-07, Vol.176 (14), p.2382-2401

2019

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Pathological changes in GPCR signal organisation: Opportunities for targeted therapies for triple negative breast cancer

Pharmacology & therapeutics (Oxford), 2023-01, Vol.241, p.108331-108331, Article 108331

2023

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Muscarinic receptors stimulate AC2 by novel phosphorylation sites, whereas Gβγ subunits exert opposing effects depending on the G-protein source

Biochemical journal, 2012-11, Vol.447 (3), p.393-405

2012

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Glucagon-like peptide-1 receptor internalisation controls spatiotemporal signalling mediated by biased agonists

Biochemical pharmacology, 2018-10, Vol.156, p.406-419

2018

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Three-dimensional imaging on a chip using optofluidics light-sheet fluorescence microscopy

Lab on a chip, 2021-08, Vol.21 (15), p.2945-2954

2021

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Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

Proceedings of the National Academy of Sciences - PNAS, 2018-07, Vol.115 (31), p.E7438-E7447

2018

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Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists

The application of targeted protein degradation technologies to G protein‐coupled receptors

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

Compartmentalization of GPCR signalling controls unique cellular responses

International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1-4, the receptors for relaxin family peptides

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

Illuminating GPCR trafficking

Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations

The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells

The complexity of signalling mediated by the glucagon-like peptide-1 receptor

Inhibition of the Proliferation of Human Lung Fibroblasts by Prostacyclin Receptor Agonists is Linked to a Sustained cAMP Signal in the Nucleus

Editorial: Recent Advances in G Protein-Coupled Receptor Signalling: Impact of Intracellular Location, Environment and Biased Agonism

Localised GPCR signalling as revealed by FRET biosensors

Signal transduction pathways activated by insulin‐like peptide 5 at the relaxin family peptide RXFP4 receptor

GRK Mediates μ-Opioid Receptor Plasma Membrane Reorganization

Genetically Encoded FRET Biosensors to Illuminate Compartmentalised GPCR Signalling

Relaxin Family Peptide Receptors RXFP1 and RXFP2 Modulate cAMP Signaling by Distinct Mechanisms

Adenylyl cyclase signalling complexes - Pharmacological challenges and opportunities

Signalling in response to sub‐picomolar concentrations of active compounds: Pushing the boundaries of GPCR sensitivity

Pathological changes in GPCR signal organisation: Opportunities for targeted therapies for triple negative breast cancer

Muscarinic receptors stimulate AC2 by novel phosphorylation sites, whereas Gβγ subunits exert opposing effects depending on the G-protein source

Glucagon-like peptide-1 receptor internalisation controls spatiotemporal signalling mediated by biased agonists

Three-dimensional imaging on a chip using optofluidics light-sheet fluorescence microscopy

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

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