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Lipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson's disease

Journal of neuroinflammation, 2019-07, Vol.16 (1), p.153-153, Article 153

2019

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Successful Function of Autologous iPSC-Derived Dopamine Neurons following Transplantation in a Non-Human Primate Model of Parkinson’s Disease

Cell stem cell, 2015-03, Vol.16 (3), p.269-274

2015

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The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress

Neurobiology of disease, 2018-12, Vol.120, p.1-11

2018

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Long-Term Health of Dopaminergic Neuron Transplants in Parkinson's Disease Patients

Cell reports (Cambridge), 2014-06, Vol.7 (6), p.1755-1761

2014

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Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease

Molecular neurodegeneration, 2019-11, Vol.14 (1), p.40-40, Article 40

2019

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Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats

Proceedings of the National Academy of Sciences - PNAS, 2010-09, Vol.107 (36), p.15921-15926

2010

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Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons

Neurobiology of disease, 2015-10, Vol.82, p.495-503

2015

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Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age

Scientific reports, 2018-10, Vol.8 (1), p.15207-11, Article 15207

2018

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Viral-like TLR3 induction of cytokine networks and α-synuclein are reduced by complement C3 blockade in mouse brain

Scientific reports, 2023-09, Vol.13 (1), p.15164-14, Article 15164

2023

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Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits

Neurobiology of disease, 2012-08, Vol.47 (2), p.258-267

2012

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A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C)

PloS one, 2015-03, Vol.10 (3), p.e0121072-e0121072

2015

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Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection

Neuroscience letters, 2014-07, Vol.576, p.73-78

2014

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Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease

Neurobiology of disease, 2014-04, Vol.64 (100), p.79-87

2014

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Advantages and Recent Developments of Autologous Cell Therapy for Parkinson's Disease Patients

Frontiers in cellular neuroscience, 2020-04, Vol.14, p.58-58

2020

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Novel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and Disease

Frontiers in neurology, 2019-10, Vol.10, p.1053-1053

2019

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The Toll-like receptor-3 agonist polyinosinic:polycytidylic acid triggers nigrostriatal dopaminergic degeneration

The Journal of neuroscience, 2010-12, Vol.30 (48), p.16091-16101

2010

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Fibroblasts from idiopathic Parkinson's disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2

Molecular brain, 2021-01, Vol.14 (1), p.16-16, Article 16

2021

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Neurite Collapse and Altered ER Ca2+ Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation

Stem cell reports, 2019-01, Vol.12 (1), p.29-41

2019

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Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice

Molecular therapy. Nucleic acids, 2020-09, Vol.21, p.623-635

2020

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Rationale for and use of NMDA receptor antagonists in Parkinson's disease

Pharmacology & therapeutics (Oxford), 2004-05, Vol.102 (2), p.155-174

2004

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Loss of Lipid Carrier ApoE Exacerbates Brain Glial and Inflammatory Responses after Lysosomal GBA1 Inhibition

Cells (Basel, Switzerland), 2023-11, Vol.12 (21), p.2564

2023

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Cell type-specific lipid storage changes in Parkinson’s disease patient brains are recapitulated by experimental glycolipid disturbance

Proceedings of the National Academy of Sciences - PNAS, 2020-11, Vol.117 (44), p.27646-27654

2020

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Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity

Acta neuropathologica communications, 2020-08, Vol.8 (1), p.127-14, Article 127

2020

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Striatal histone modifications in models of levodopa-induced dyskinesia

Journal of neurochemistry, 2008-07, Vol.106 (1), p.486-494

2008

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Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression

Proceedings of the National Academy of Sciences - PNAS, 2009-12, Vol.106 (52), p.22474-22479

2009

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Lipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson's disease

Successful Function of Autologous iPSC-Derived Dopamine Neurons following Transplantation in a Non-Human Primate Model of Parkinson’s Disease

The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress

Long-Term Health of Dopaminergic Neuron Transplants in Parkinson's Disease Patients

Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease

Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats

Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons

Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age

Viral-like TLR3 induction of cytokine networks and α-synuclein are reduced by complement C3 blockade in mouse brain

Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits

A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C)

Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection

Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease

Advantages and Recent Developments of Autologous Cell Therapy for Parkinson's Disease Patients

Novel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and Disease

The Toll-like receptor-3 agonist polyinosinic:polycytidylic acid triggers nigrostriatal dopaminergic degeneration

Fibroblasts from idiopathic Parkinson's disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2

Neurite Collapse and Altered ER Ca2+ Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation

Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice

Rationale for and use of NMDA receptor antagonists in Parkinson's disease

Loss of Lipid Carrier ApoE Exacerbates Brain Glial and Inflammatory Responses after Lysosomal GBA1 Inhibition

Cell type-specific lipid storage changes in Parkinson’s disease patient brains are recapitulated by experimental glycolipid disturbance

Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity

Striatal histone modifications in models of levodopa-induced dyskinesia

Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression

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