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Topically applied novel TRPV1 receptor antagonist, ACD440 Gel, reduces evoked pain in healthy volunteers, a randomized, double-blind, placebo-controlled, crossover study

European journal of pain, 2024-06

2024

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ACD856, a novel positive allosteric modulator of Trk receptors, single ascending doses in healthy subjects: Safety and pharmacokinetics

European journal of clinical pharmacology, 2024-05, Vol.80 (5), p.717-727

2024

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Preclinical characterization of three transient receptor potential vanilloid receptor 1 antagonists for early use in human intradermal microdose analgesic studies

European journal of pain, 2018-05, Vol.22 (5), p.889-903

2018

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Clinical testing of three novel transient receptor potential cation channel subfamily V member 1 antagonists in a pharmacodynamic intradermal capsaicin model

European journal of pain, 2018-08, Vol.22 (7), p.1214-1228

2018

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Safety, Tolerability, Pharmacokinetics and Quantitative Electroencephalography Assessment of ACD856, a Novel Positive Allosteric Modulator of Trk-Receptors Following Multiple Doses in Healthy Subjects

The Journal Of Prevention of Alzheimer's Disease, 2023, Vol.10 (4), p.778-789

2023

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Identification of Novel Positive Allosteric Modulators of Neurotrophin Receptors for the Treatment of Cognitive Dysfunction

Cells (Basel, Switzerland), 2021-07, Vol.10 (8), p.1871

2021

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The effect of intradermal microdosing of a transient receptor potential cation channel subfamily V member 1 antagonist on heat evoked pain and thermal thresholds in normal and ultraviolet‐C exposed skin in healthy volunteers

European journal of pain, 2019-11, Vol.23 (10), p.1767-1779

2019

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Assessment of Free Drug Concentration in Cyclodextrin Formulations Is Essential to Determine Drug Potency in Functional In Vitro Assays

Journal of pharmaceutical sciences, 2016-09, Vol.105 (9), p.2913-2920

2016

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Most patients with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency develop pathological or subnormal retinal function

Acta Paediatrica, 2016-12, Vol.105 (12), p.1451-1460

2016

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The metabolic syndrome: Prevalence and association to leisure-time and work-related physical activity in 60-year-old men and women

Nutrition, metabolism, and cardiovascular diseases, 2007-06, Vol.17 (5), p.349-357

2007

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Increased and early lipolysis in children with long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency during fast

Journal of inherited metabolic disease, 2015-03, Vol.38 (2), p.315-322

2015

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The battle of Alzheimer's Disease - the beginning of the future Unleashing the potential of academic discoveries

Frontiers in pharmacology, 2014, Vol.5, p.102-102

2014

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The impact of the site of blood sampling on pharmacokinetic parameters following sublingual dosing to dogs

Journal of pharmacological and toxicological methods, 2013-01, Vol.67 (1), p.1-4

2013

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Increased lipolysis in LCHAD deficiency

Journal of inherited metabolic disease, 2007-02, Vol.30 (1), p.39-46

2007

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Erratum to: Increased and early lipolysis in children with long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency during fast

Journal of inherited metabolic disease, 2015-03, Vol.38 (2), p.377-377

2015

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Incidence of Idiopathic Intracranial Hypertension in Individuals With Gonadotropin-Releasing Hormone Analogue Treatment for Gender Dysphoria in Sweden

JAMA pediatrics, 2023-07, Vol.177 (7), p.726

2023

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Metabolism and excretion of ropivacaine in humans

Drug metabolism and disposition, 1996-09, Vol.24 (9), p.962

1996

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P.0229 Characterization of positive allosteric modulators of trkb for the treatment of depression

European neuropsychopharmacology, 2021-12, Vol.53, p.S166-S167

2021

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Insulin sensitivity and lipolysis in adolescent girls with poorly controlled type 1 diabetes: effect of anticholinergic treatment

Clinical endocrinology (Oxford), 2002-12, Vol.57 (6), p.735-743

2002

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Neuropsychological Development in Patients with Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase (LCHAD) Deficiency

JIMD Reports, Volume 28, 2016-01, Vol.28, p.75-84

2016

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Physical activity attenuates cardiovascular risk and mortality in men and women with and without the metabolic syndrome - a 20-year follow-up of a population-based cohort of 60-year-olds

European journal of preventive cardiology, 2021, Vol.28 (12), p.1376-1385

2021

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trial with N-carbamylglutamate may not detect all patients with NAGS deficiency and neonatal onset

Journal of inherited metabolic disease, 2007-06, Vol.30 (3), p.400-400

2007

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Adenosine Kinase Deficiency Disrupts the Methionine Cycle and Causes Hypermethioninemia, Encephalopathy, and Abnormal Liver Function

American journal of human genetics, 2011-10, Vol.89 (4), p.507-515

2011

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Absence of TXNIP in Humans Leads to Lactic Acidosis and Low Serum Methionine Linked to Deficient Respiration on Pyruvate

Diabetes (New York, N.Y.), 2019-04, Vol.68 (4), p.709-723

2019

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Pragmatic Approaches to Determine the Exposures of Drug Metabolites in Preclinical and Clinical Subjects in the MIST Evaluation of the Clinical Development Phase

Chemical research in toxicology, 2014-04, Vol.27 (4), p.601-610

2014

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Topically applied novel TRPV1 receptor antagonist, ACD440 Gel, reduces evoked pain in healthy volunteers, a randomized, double-blind, placebo-controlled, crossover study

ACD856, a novel positive allosteric modulator of Trk receptors, single ascending doses in healthy subjects: Safety and pharmacokinetics

Preclinical characterization of three transient receptor potential vanilloid receptor 1 antagonists for early use in human intradermal microdose analgesic studies

Clinical testing of three novel transient receptor potential cation channel subfamily V member 1 antagonists in a pharmacodynamic intradermal capsaicin model

Safety, Tolerability, Pharmacokinetics and Quantitative Electroencephalography Assessment of ACD856, a Novel Positive Allosteric Modulator of Trk-Receptors Following Multiple Doses in Healthy Subjects

Identification of Novel Positive Allosteric Modulators of Neurotrophin Receptors for the Treatment of Cognitive Dysfunction

The effect of intradermal microdosing of a transient receptor potential cation channel subfamily V member 1 antagonist on heat evoked pain and thermal thresholds in normal and ultraviolet‐C exposed skin in healthy volunteers

Assessment of Free Drug Concentration in Cyclodextrin Formulations Is Essential to Determine Drug Potency in Functional In Vitro Assays

Most patients with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency develop pathological or subnormal retinal function

The metabolic syndrome: Prevalence and association to leisure-time and work-related physical activity in 60-year-old men and women

Increased and early lipolysis in children with long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency during fast

The battle of Alzheimer's Disease - the beginning of the future Unleashing the potential of academic discoveries

The impact of the site of blood sampling on pharmacokinetic parameters following sublingual dosing to dogs

Increased lipolysis in LCHAD deficiency

Erratum to: Increased and early lipolysis in children with long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency during fast

Incidence of Idiopathic Intracranial Hypertension in Individuals With Gonadotropin-Releasing Hormone Analogue Treatment for Gender Dysphoria in Sweden

Metabolism and excretion of ropivacaine in humans

P.0229 Characterization of positive allosteric modulators of trkb for the treatment of depression

Insulin sensitivity and lipolysis in adolescent girls with poorly controlled type 1 diabetes: effect of anticholinergic treatment

Neuropsychological Development in Patients with Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase (LCHAD) Deficiency

Physical activity attenuates cardiovascular risk and mortality in men and women with and without the metabolic syndrome - a 20-year follow-up of a population-based cohort of 60-year-olds

trial with N-carbamylglutamate may not detect all patients with NAGS deficiency and neonatal onset

Adenosine Kinase Deficiency Disrupts the Methionine Cycle and Causes Hypermethioninemia, Encephalopathy, and Abnormal Liver Function

Absence of TXNIP in Humans Leads to Lactic Acidosis and Low Serum Methionine Linked to Deficient Respiration on Pyruvate

Pragmatic Approaches to Determine the Exposures of Drug Metabolites in Preclinical and Clinical Subjects in the MIST Evaluation of the Clinical Development Phase

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