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Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: A novel mechanism for implant debris reactivity

Journal of orthopaedic research, 2009-07, Vol.27 (7), p.847-854

2009

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Increasing both CoCrMo-alloy particle size and surface irregularity induces increased macrophage inflammasome activation in vitro potentially through lysosomal destabilization mechanisms

Journal of orthopaedic research, 2013-10, Vol.31 (10), p.1633-1642

2013

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Cobalt-alloy implant debris induce HIF-1α hypoxia associated responses: a mechanism for metal-specific orthopedic implant failure

PloS one, 2013-06, Vol.8 (6), p.e67127

2013

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Micrometer-sized titanium particles can induce potent Th2-type responses through TLR4-independent pathways

The Journal of immunology (1950), 2011-12, Vol.187 (12), p.6491-6498

2011

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Influence of pH on the tribocorrosion behavior of CpTi in the oral environment: synergistic interactions of wear and corrosion

Journal of biomedical materials research. Part B, Applied biomaterials, 2012-08, Vol.100B (6), p.1662-1671

2012

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Metal-on-metal bearing surfaces

Journal of the American Academy of Orthopaedic Surgeons, 2009-02, Vol.17 (2), p.69-76

2009

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COVID-19 (SARS-CoV-2) lymphocyte responses are associated with inflammatory biomarkers in total joint replacement surgery candidates pre-operatively

Journal of orthopaedic surgery and research, 2021-06, Vol.16 (1), p.1-415, Article 415

2021

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Biologic Responses to Orthopedic Implants: Innate and Adaptive Immune Responses to Implant Debris

Spine (Philadelphia, Pa. 1976), 2016-04, Vol.41 Suppl 7, p.S30-S31

Hallab, Nadim J

2016

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Characterization of residual debris on packaged hip arthroplasty stems demonstrates the dominance of less than 10 μm sized particulate: Updated USP788 guidelines for orthopedic implants

Journal of biomedical materials research. Part B, Applied biomaterials, 2024-02, Vol.112 (2), p.e35387-e35387

2024

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Spinal implant debris-induced osteolysis

Spine (Philadelphia, Pa. 1976), 2003-10, Vol.28 (20), p.S125-S138

2003

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Biological Responses to Spinal Implant Debris

Spine (Philadelphia, Pa. 1976), 2017-04, Vol.42 Suppl 7 (7), p.S4-S5

Hallab, Nadim J

2017

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Orthopedic implant cobalt-alloy particles produce greater toxicity and inflammatory cytokines than titanium alloy and zirconium alloy-based particles in vitro, in human osteoblasts, fibroblasts, and macrophages

Journal of biomedical materials research. Part A, 2012-08, Vol.100A (8), p.2147-2158

2012

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Metal release in patients who have had a primary total hip arthroplasty. A prospective, controlled, longitudinal study

Journal of bone and joint surgery. American volume, 1998-10, Vol.80 (10), p.1447-58

1998

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Chemokines Associated with Pathologic Responses to Orthopedic Implant Debris

Frontiers in endocrinology (Lausanne), 2017-01, Vol.8, p.5-5

2017

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Biologic effects of implant debris

Bulletin of the NYU Hospital for Joint Diseases, 2009, Vol.67 (2), p.182

2009

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Evaluation and treatment of painful total hip arthroplasties with modular metal taper junctions

Orthopedics (Thorofare, N.J.), 2012-05, Vol.35 (5), p.386-391

2012

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TLR4 (not TLR2) dominate cognate TLR activity associated with CoCrMo implant particles

Journal of orthopaedic research, 2017-05, Vol.35 (5), p.1007-1017

2017

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In vitro simulation of fretting-corrosion in hip implant modular junctions: The influence of pH

Medical engineering & physics, 2018-02, Vol.52, p.1-9

2018

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Sterile particle-induced inflammation is mediated by macrophages releasing IL-33 through a Bruton's tyrosine kinase-dependent pathway

Nature materials, 2019-03, Vol.18 (3), p.289-297

2019

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Do Battlefield Injury-acquired Indwelling Metal Fragments Induce Metal Immunogenicity?

Clinical orthopaedics and related research, 2020-04, Vol.478 (4), p.752-766

2020

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Loosening and Osteolysis Associated with Metal-on-Metal Bearings: A Local Effect of Metal Hypersensitivity?

Journal of bone and joint surgery. American volume, 2006-06, Vol.88 (6), p.1171-1172

2006

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Soluble ions more than particulate cobalt-alloy implant debris induce monocyte costimulatory molecule expression and release of proinflammatory cytokines critical to metal-induced lymphocyte reactivity

Journal of biomedical materials research. Part A, 2010-06, Vol.93A (4), p.1312-1321

2010

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Fretting-corrosion in hip taper modular junctions: The influence of topography and pH levels – An in-vitro study

Journal of the mechanical behavior of biomedical materials, 2021-06, Vol.118, p.104443-104443, Article 104443

2021

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Females with Unexplained Joint Pain Following Total Joint Arthroplasty Exhibit a Higher Rate and Severity of Hypersensitivity to Implant Metals Compared with Males: Implications of Sex-Based Bioreactivity Differences

Journal of bone and joint surgery. American volume, 2017-04, Vol.99 (8), p.621-628

2017

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Strain-controlled enzymatic cleavage of collagen in loaded matrix

Biochemical and biophysical research communications, 2005-10, Vol.336 (2), p.483-489

2005

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Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: A novel mechanism for implant debris reactivity

Increasing both CoCrMo-alloy particle size and surface irregularity induces increased macrophage inflammasome activation in vitro potentially through lysosomal destabilization mechanisms

Cobalt-alloy implant debris induce HIF-1α hypoxia associated responses: a mechanism for metal-specific orthopedic implant failure

Micrometer-sized titanium particles can induce potent Th2-type responses through TLR4-independent pathways

Influence of pH on the tribocorrosion behavior of CpTi in the oral environment: synergistic interactions of wear and corrosion

Metal-on-metal bearing surfaces

COVID-19 (SARS-CoV-2) lymphocyte responses are associated with inflammatory biomarkers in total joint replacement surgery candidates pre-operatively

Biologic Responses to Orthopedic Implants: Innate and Adaptive Immune Responses to Implant Debris

Characterization of residual debris on packaged hip arthroplasty stems demonstrates the dominance of less than 10 μm sized particulate: Updated USP788 guidelines for orthopedic implants

Spinal implant debris-induced osteolysis

Biological Responses to Spinal Implant Debris

Orthopedic implant cobalt-alloy particles produce greater toxicity and inflammatory cytokines than titanium alloy and zirconium alloy-based particles in vitro, in human osteoblasts, fibroblasts, and macrophages

Metal release in patients who have had a primary total hip arthroplasty. A prospective, controlled, longitudinal study

Chemokines Associated with Pathologic Responses to Orthopedic Implant Debris

Biologic effects of implant debris

Evaluation and treatment of painful total hip arthroplasties with modular metal taper junctions

TLR4 (not TLR2) dominate cognate TLR activity associated with CoCrMo implant particles

In vitro simulation of fretting-corrosion in hip implant modular junctions: The influence of pH

Sterile particle-induced inflammation is mediated by macrophages releasing IL-33 through a Bruton's tyrosine kinase-dependent pathway

Do Battlefield Injury-acquired Indwelling Metal Fragments Induce Metal Immunogenicity?

Loosening and Osteolysis Associated with Metal-on-Metal Bearings: A Local Effect of Metal Hypersensitivity?

Soluble ions more than particulate cobalt-alloy implant debris induce monocyte costimulatory molecule expression and release of proinflammatory cytokines critical to metal-induced lymphocyte reactivity

Fretting-corrosion in hip taper modular junctions: The influence of topography and pH levels – An in-vitro study

Females with Unexplained Joint Pain Following Total Joint Arthroplasty Exhibit a Higher Rate and Severity of Hypersensitivity to Implant Metals Compared with Males: Implications of Sex-Based Bioreactivity Differences

Strain-controlled enzymatic cleavage of collagen in loaded matrix

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