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The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease

Journal of medicinal chemistry, 2020-05, Vol.63 (10), p.5031-5073

2020

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GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees

Gastroenterology (New York, N.Y. 1943), 2013-06, Vol.144 (7), p.1508-1517.e10

2013

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Pharmacokinetic and pharmacodynamic properties of GS-9620, a novel Toll-like receptor 7 agonist, demonstrate interferon-stimulated gene induction without detectable serum interferon at low oral doses

The Journal of pharmacology and experimental therapeutics, 2014-01, Vol.348 (1), p.96-105

2014

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Selective thyroid hormone receptor β agonists with oxadiazolone acid isosteres

Bioorganic & medicinal chemistry letters, 2020-11, Vol.30 (21), p.127465-127465, Article 127465

2020

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Identification and Optimization of Pteridinone Toll-like Receptor 7 (TLR7) Agonists for the Oral Treatment of Viral Hepatitis

Journal of medicinal chemistry, 2013-09, Vol.56 (18), p.7324-7333

2013

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Antibody–Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs

Molecular pharmaceutics, 2015-11, Vol.12 (11), p.3986-3998

2015

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Total Synthesis of (+)-Phomactin A Using a B-Alkyl Suzuki Macrocyclization

Journal of the American Chemical Society, 2003-02, Vol.125 (7), p.1712-1713

2003

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Application of Serine- and Threonine-Derived Cyclic Sulfamidates for the Preparation of S-Linked Glycosyl Amino Acids in Solution- and Solid-Phase Peptide Synthesis

Journal of the American Chemical Society, 2002-03, Vol.124 (11), p.2534-2543

2002

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Functional Label-Free Assays for Characterizing the in Vitro Mechanism of Action of Small Molecule Modulators of Capsid Assembly

Biochemistry (Easton), 2015-04, Vol.54 (13), p.2240-2248

2015

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Synthesis of the Ring System of Phomactin D Using a Suzuki Macrocyclization

Organic letters, 2000-08, Vol.2 (17), p.2687-2690

2000

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Exploration of factors driving incorporation of unnatural dNTPS into DNA by Klenow fragment (DNA polymerase I) and DNA polymerase alpha

Nucleic acids research, 2005, Vol.33 (8), p.2620

2005

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Synthesis of an Isostere of an O-Linked Glycopeptide

Organic letters, 2004-09, Vol.6 (19), p.3221-3224

2004

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Convergent Enantioselective Synthesis of the Tricyclic Core of Phomactin A

Organic letters, 2002-07, Vol.4 (14), p.2413-2416

2002

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Clinical targeting of HIV capsid protein with a long-acting small molecule

Nature (London), 2020-08, Vol.584 (7822), p.614-618

2020

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On the direct epoxidation of glycals: application of a reiterative strategy for the synthesis of .beta.-linked oligosaccharides

Journal of the American Chemical Society, 1989-08, Vol.111 (17), p.6661-6666

1989

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FRI-314-A novel semicarbazide-sensitive amine oxidase inhibitor, TERN-201, reduces NAS and fibrosis in rodent models of non-alcoholic steatohepatitis

Journal of hepatology, 2019-04, Vol.70 (1), p.e534-e535

2019

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FRI-313-A novel farnesoid X receptor agonist, TERN-101, reduces liver steatosis, inflammation, ballooning and fibrosis in a murine model of non-alcoholic steatohepatitis

Journal of hepatology, 2019-04, Vol.70 (1), p.e534-e534

2019

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Synthesis of S-Linked Glycosyl Amino Acids in Aqueous Solution with Unprotected Carbohydrates

Organic letters, 2001-02, Vol.3 (3), p.405-407

2001

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Synthesis of a Six-Carbon Sialic Acid Using an Indium-Mediated Coupling

Organic letters, 2000-07, Vol.2 (14), p.2003-2005

2000

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Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B

Journal of hepatology, 2015-06, Vol.62 (6), p.1237-1245

2015

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Solution- and Solid-Phase Synthesis of Inhibitors of H. pylori Attachment and E-Selectin-Mediated Leukocyte Adhesion

Journal of the American Chemical Society, 1994-12, Vol.116 (25), p.11315-11322

1994

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Stereoselective Synthesis of Conformationally Constrained Glycosylated Amino Acids Using an Enzyme-Catalyzed Desymmetrization

Journal of organic chemistry, 2003-02, Vol.68 (4), p.1348-1357

2003

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A New Method for the Stereoselective Synthesis of α-Substituted Serine Amino Acid Analogues

Organic letters, 2003-10, Vol.5 (22), p.4017-4020

2003

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Design and Synthesis of Conformationally Constrained Glycosylated Amino Acids

Journal of organic chemistry, 2001-04, Vol.66 (7), p.2318-2326

2001

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Synthesis and Characterization of an Anomeric Sulfur Analogue of CMP-Sialic Acid

Journal of organic chemistry, 2000-09, Vol.65 (19), p.6145-6152

2000

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The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease

GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees

Pharmacokinetic and pharmacodynamic properties of GS-9620, a novel Toll-like receptor 7 agonist, demonstrate interferon-stimulated gene induction without detectable serum interferon at low oral doses

Selective thyroid hormone receptor β agonists with oxadiazolone acid isosteres

Identification and Optimization of Pteridinone Toll-like Receptor 7 (TLR7) Agonists for the Oral Treatment of Viral Hepatitis

Antibody–Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs

Total Synthesis of (+)-Phomactin A Using a B-Alkyl Suzuki Macrocyclization

Application of Serine- and Threonine-Derived Cyclic Sulfamidates for the Preparation of S-Linked Glycosyl Amino Acids in Solution- and Solid-Phase Peptide Synthesis

Functional Label-Free Assays for Characterizing the in Vitro Mechanism of Action of Small Molecule Modulators of Capsid Assembly

Synthesis of the Ring System of Phomactin D Using a Suzuki Macrocyclization

Exploration of factors driving incorporation of unnatural dNTPS into DNA by Klenow fragment (DNA polymerase I) and DNA polymerase alpha

Synthesis of an Isostere of an O-Linked Glycopeptide

Convergent Enantioselective Synthesis of the Tricyclic Core of Phomactin A

Clinical targeting of HIV capsid protein with a long-acting small molecule

On the direct epoxidation of glycals: application of a reiterative strategy for the synthesis of .beta.-linked oligosaccharides

FRI-314-A novel semicarbazide-sensitive amine oxidase inhibitor, TERN-201, reduces NAS and fibrosis in rodent models of non-alcoholic steatohepatitis

FRI-313-A novel farnesoid X receptor agonist, TERN-101, reduces liver steatosis, inflammation, ballooning and fibrosis in a murine model of non-alcoholic steatohepatitis

Synthesis of S-Linked Glycosyl Amino Acids in Aqueous Solution with Unprotected Carbohydrates

Synthesis of a Six-Carbon Sialic Acid Using an Indium-Mediated Coupling

Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B

Solution- and Solid-Phase Synthesis of Inhibitors of H. pylori Attachment and E-Selectin-Mediated Leukocyte Adhesion

Stereoselective Synthesis of Conformationally Constrained Glycosylated Amino Acids Using an Enzyme-Catalyzed Desymmetrization

A New Method for the Stereoselective Synthesis of α-Substituted Serine Amino Acid Analogues

Design and Synthesis of Conformationally Constrained Glycosylated Amino Acids

Synthesis and Characterization of an Anomeric Sulfur Analogue of CMP-Sialic Acid

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