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Dysregulation of the mevalonate pathway promotes transformation

Proceedings of the National Academy of Sciences - PNAS, 2010-08, Vol.107 (34), p.15051-15056

2010

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RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks

Proceedings of the National Academy of Sciences - PNAS, 2013-12, Vol.110 (52), p.20982-20987

2013

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RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation

Nature communications, 2016-08, Vol.7 (1), p.12638-13, Article 12638

2016

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Pirh2 E3 Ubiquitin Ligase Monoubiquitinates DNA Polymerase Eta To Suppress Translesion DNA Synthesis

Molecular and Cellular Biology, 2011-10, Vol.31 (19), p.3997-4006

2011

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Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer

The Journal of experimental medicine, 2010-05, Vol.207 (5), p.983-997

2010

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RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis

Genes & development, 2005-09, Vol.19 (17), p.1974-1979

2005

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A high-throughput approach to identify BRCA1-downregulating compounds to enhance PARP inhibitor sensitivity

iScience, 2024-07, Vol.27 (7), p.110180, Article 110180

2024

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Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity

The EMBO journal, 2004-09, Vol.23 (18), p.3677-3688

2004

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Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development

Cell, 1998-09, Vol.94 (6), p.739-750

1998

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Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis

PLoS genetics, 2013-01, Vol.9 (1), p.e1003259

2013

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Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer

PLoS genetics, 2011-05, Vol.7 (5), p.e1001385-e1001385

2011

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Functional interplay of p53 and Mus81 in DNA damage responses and cancer

Cancer research (Chicago, Ill.), 2007-09, Vol.67 (18), p.8527-8535

2007

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Collaboration of Brca1 and Chk2 in tumorigenesis

Genes & development, 2004-05, Vol.18 (10), p.1144-1153

2004

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Pirh2: An E3 ligase with central roles in the regulation of cell cycle, DNA damage response, and differentiation

Cell cycle (Georgetown, Tex.), 2013-09, Vol.12 (17), p.2733-2737

2013

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The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis

The Journal of experimental medicine, 1999-03, Vol.189 (6), p.957-968

1999

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RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors

The Journal of clinical investigation, 2021-02, Vol.131 (3), p.1-14

2021

Volltextzugriff (PDF)

Dual Role of Caspase 8 in Adipocyte Apoptosis and Metabolic Inflammation

Diabetes (New York, N.Y.), 2023-12, Vol.72 (12), p.1751-1765

2023

Volltextzugriff (PDF)

Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis

The Journal of clinical investigation, 2018-10, Vol.128 (10), p.4525-4542

2018

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Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers

Nucleic acids research, 2023-05, Vol.51 (9), p.4341

2023

Volltextzugriff (PDF)

Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis

The Journal of clinical investigation, 2021-07, Vol.131 (13)

2021

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Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

Genes & development, 2003-04, Vol.17 (7), p.883-895

2003

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Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

Genes & development, 1998-03, Vol.12 (6), p.806-819

1998

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The Interferon Regulatory Transcription Factor IRF-1 Controls Positive and Negative Selection of CD8 + Thymocytes

Immunity (Cambridge, Mass.), 1997-08, Vol.7 (2), p.243-254

1997

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Essential Role for Caspase-8 in Toll-like Receptors and NFκB Signaling

The Journal of biological chemistry, 2007-03, Vol.282 (10), p.7416-7423

2007

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Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in Bim-/- mice

The Journal of cell biology, 2011-10, Vol.195 (2), p.277-291

2011

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Dysregulation of the mevalonate pathway promotes transformation

RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks

RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation

Pirh2 E3 Ubiquitin Ligase Monoubiquitinates DNA Polymerase Eta To Suppress Translesion DNA Synthesis

Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer

RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis

A high-throughput approach to identify BRCA1-downregulating compounds to enhance PARP inhibitor sensitivity

Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity

Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development

Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis

Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer

Functional interplay of p53 and Mus81 in DNA damage responses and cancer

Collaboration of Brca1 and Chk2 in tumorigenesis

Pirh2: An E3 ligase with central roles in the regulation of cell cycle, DNA damage response, and differentiation

The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis

RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors

Dual Role of Caspase 8 in Adipocyte Apoptosis and Metabolic Inflammation

Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis

Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers

Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

The Interferon Regulatory Transcription Factor IRF-1 Controls Positive and Negative Selection of CD8 + Thymocytes

Essential Role for Caspase-8 in Toll-like Receptors and NFκB Signaling

Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in Bim-/- mice

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