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The Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer

Mediators of inflammation, 2017-01, Vol.2017, p.4806541-17

2017

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Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

Cancer cell, 2013-01, Vol.23 (1), p.107-120

2013

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Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential

Mediators of inflammation, 2016-01, Vol.2016, p.8606878-11

2016

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Metastatic triple-negative breast cancer is dependent on SphKs/S1P signaling for growth and survival

Cellular signalling, 2017-04, Vol.32, p.85-92

2017

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Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

Science (American Association for the Advancement of Science), 2009-09, Vol.325 (5945), p.1254-1257

2009

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Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

Nature (London), 2010-06, Vol.465 (7301), p.1084-1088

2010

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Regulation of hypoxia‐inducible factor functions in the nucleus by sphingosine‐1‐phosphate

The FASEB journal, 2020-03, Vol.34 (3), p.4293-4310

2020

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The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases

Journal of lipid research, 2016-09, Vol.57 (9), p.1636-1643

2016

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Conjugated bile acid–activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression

Hepatology (Baltimore, Md.), 2015-04, Vol.61 (4), p.1216-1226

2015

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Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

Nature neuroscience, 2014-07, Vol.17 (7), p.971-980

2014

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Doxorubicin effect is enhanced by sphingosine-1-phosphate signaling antagonist in breast cancer

The Journal of surgical research, 2017-11, Vol.219, p.202-213

2017

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Estradiol Induces Export of Sphingosine 1-Phosphate from Breast Cancer Cells via ABCC1 and ABCG2

The Journal of biological chemistry, 2010-04, Vol.285 (14), p.10477-10486

2010

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Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent

PloS one, 2013-02, Vol.8 (2), p.e56471-e56471

2013

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Spinster 2, a sphingosine‐1‐phosphate transporter, plays a critical role in inflammatory and autoimmune diseases

The FASEB journal, 2015-12, Vol.29 (12), p.5018-5028

2015

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Aberrant ORM (yeast)–like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice

Journal of allergy and clinical immunology, 2015-10, Vol.136 (4), p.1035-1046.e6

2015

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K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5

Nature immunology, 2014-03, Vol.15 (3), p.231

2014

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Quantitative global lipidomics analysis of patients with ovarian cancer versus benign adnexal mass

Scientific reports, 2021-09, Vol.11 (1), p.18156-18156, Article 18156

2021

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SphK1 and SphK2, Sphingosine Kinase Isoenzymes with Opposing Functions in Sphingolipid Metabolism

The Journal of biological chemistry, 2005-11, Vol.280 (44), p.37118-37129

2005

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FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann‐Pick type C mutant fibroblasts

The FASEB journal, 2017-04, Vol.31 (4), p.1719-1730

2017

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Sphingosine Kinase Type 2 Activation by ERK-mediated Phosphorylation

The Journal of biological chemistry, 2007-04, Vol.282 (16), p.12058-12065

2007

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Targeting Sphingosine Kinase 1 Inhibits Akt Signaling, Induces Apoptosis, and Suppresses Growth of Human Glioblastoma Cells and Xenografts

Cancer research (Chicago, Ill.), 2009-09, Vol.69 (17), p.6915-6923

2009

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Plasma Sphingosine-1-Phosphate Levels Are Associated with Progression of Estrogen Receptor-Positive Breast Cancer

International journal of molecular sciences, 2021-12, Vol.22 (24), p.13367

2021

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The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell–dependent acute allergic responses

Journal of allergy and clinical immunology, 2015-04, Vol.135 (4), p.1008-1018.e1

2015

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Sphingosine-1-phosphate in chronic intestinal inflammation and cancer

Advances in biological regulation, 2014, Vol.54, p.112-120

2014

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Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema

The Journal of experimental medicine, 2010-03, Vol.207 (3), p.465-474

2010

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The Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential

Metastatic triple-negative breast cancer is dependent on SphKs/S1P signaling for growth and survival

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

Regulation of hypoxia‐inducible factor functions in the nucleus by sphingosine‐1‐phosphate

The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases

Conjugated bile acid–activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

Doxorubicin effect is enhanced by sphingosine-1-phosphate signaling antagonist in breast cancer

Estradiol Induces Export of Sphingosine 1-Phosphate from Breast Cancer Cells via ABCC1 and ABCG2

Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent

Spinster 2, a sphingosine‐1‐phosphate transporter, plays a critical role in inflammatory and autoimmune diseases

Aberrant ORM (yeast)–like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice

K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5

Quantitative global lipidomics analysis of patients with ovarian cancer versus benign adnexal mass

SphK1 and SphK2, Sphingosine Kinase Isoenzymes with Opposing Functions in Sphingolipid Metabolism

FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann‐Pick type C mutant fibroblasts

Sphingosine Kinase Type 2 Activation by ERK-mediated Phosphorylation

Targeting Sphingosine Kinase 1 Inhibits Akt Signaling, Induces Apoptosis, and Suppresses Growth of Human Glioblastoma Cells and Xenografts

Plasma Sphingosine-1-Phosphate Levels Are Associated with Progression of Estrogen Receptor-Positive Breast Cancer

The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell–dependent acute allergic responses

Sphingosine-1-phosphate in chronic intestinal inflammation and cancer

Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema

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