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KRAS Alleles: The Devil Is in the Detail

Trends in cancer, 2017-10, Vol.3 (10), p.686-697

Haigis, Kevin M

2017

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Tissue-specificity in cancer: The rule, not the exception

Science (American Association for the Advancement of Science), 2019-03, Vol.363 (6432), p.1150-1151

2019

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The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor

Cell, 2012-03, Vol.149 (1), p.146-158

2012

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The origins and genetic interactions of KRAS mutations are allele- and tissue-specific

Nature communications, 2021-03, Vol.12 (1), p.1808-14, Article 1808

2021

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The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation

Science (American Association for the Advancement of Science), 2021-09, Vol.373 (6561), p.1327-1335

2021

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Classification of KRAS-Activating Mutations and the Implications for Therapeutic Intervention

Cancer discovery, 2022-04, Vol.12 (4), p.913-923

2022

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Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

Nature genetics, 2008-05, Vol.40 (5), p.600-608

2008

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Regulating the regulator: post-translational modification of RAS

Nature reviews. Molecular cell biology, 2012-01, Vol.13 (1), p.39

2012

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All Roads Lead to Rome: YAP/TAZ Activity Influences Efficacy of KRASG12C Inhibitors

Cancer research (Chicago, Ill.), 2023-12, Vol.83 (24), p.4005

2023

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HDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS

Molecular cancer research, 2013-09, Vol.11 (9), p.1072-1077

2013

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Computational translation of genomic responses from experimental model systems to humans

PLoS computational biology, 2019-01, Vol.15 (1), p.e1006286-e1006286

2019

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MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis

Proceedings of the National Academy of Sciences - PNAS, 2018-05, Vol.115 (18), p.E4236-E4244

2018

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K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif

Proceedings of the National Academy of Sciences - PNAS, 2015-01, Vol.112 (3), p.779-784

2015

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SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis

Cell reports (Cambridge), 2024-04, Vol.43 (4), p.113975-113975, Article 113975

2024

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An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background

Nature (London), 2012-11, Vol.491 (7424), p.449-453

2012

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The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile

PLoS biology, 2018-03, Vol.16 (3), p.e2002417-e2002417

2018

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Regulation of RAS oncogenicity by acetylation

Proceedings of the National Academy of Sciences - PNAS, 2012-07, Vol.109 (27), p.10843-10848

2012

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SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells

Cell, 2006-09, Vol.126 (5), p.941-954

2006

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RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth

Nature cell biology, 2015-06, Vol.17 (6), p.804

2015

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Preclinical efficacy of MEK inhibition in Nras-mutant AML

Blood, 2014-12, Vol.124 (26), p.3947-3955

2014

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A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells

Cell reports (Cambridge), 2017-07, Vol.20 (2), p.427-438

2017

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Specific Mutations in KRAS Codons 12 and 13, and Patient Prognosis in 1075 BRAF Wild-Type Colorectal Cancers

Clinical cancer research, 2012-09, Vol.18 (17), p.4753-4763

2012

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Inducible and reversible inhibition of miRNA-mediated gene repression in vivo

eLife, 2021-08, Vol.10

2021

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MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer

Frontiers in immunology, 2021-02, Vol.11, p.607891-607891

2021

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A Compendium of Murine (Phospho)Peptides Encompassing Different Isobaric Labeling and Data Acquisition Strategies

Journal of proteome research, 2021-07, Vol.20 (7), p.3678-3688

2021

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KRAS Alleles: The Devil Is in the Detail

Tissue-specificity in cancer: The rule, not the exception

The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor

The origins and genetic interactions of KRAS mutations are allele- and tissue-specific

The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation

Classification of KRAS-Activating Mutations and the Implications for Therapeutic Intervention

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

Regulating the regulator: post-translational modification of RAS

All Roads Lead to Rome: YAP/TAZ Activity Influences Efficacy of KRASG12C Inhibitors

HDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS

Computational translation of genomic responses from experimental model systems to humans

MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis

K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif

SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis

An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background

The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile

Regulation of RAS oncogenicity by acetylation

SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells

RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth

Preclinical efficacy of MEK inhibition in Nras-mutant AML

A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells

Specific Mutations in KRAS Codons 12 and 13, and Patient Prognosis in 1075 BRAF Wild-Type Colorectal Cancers

Inducible and reversible inhibition of miRNA-mediated gene repression in vivo

MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer

A Compendium of Murine (Phospho)Peptides Encompassing Different Isobaric Labeling and Data Acquisition Strategies

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