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Nec‐1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice

EMBO molecular medicine, 2017-01, Vol.9 (1), p.61-77

2017

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Generation of Non-Nucleotide CD73 Inhibitors Using a Molecular Docking and 3D-QSAR Approach

International journal of molecular sciences, 2021-11, Vol.22 (23), p.12745

2021

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An Intriguing Purview on the Design of Macrocyclic Inhibitors for Unexplored Protein Kinases through Their Binding Site Comparison

Pharmaceuticals (Basel, Switzerland), 2023-07, Vol.16 (7), p.1009

2023

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Gaining Insights into Key Structural Hotspots within the Allosteric Binding Pockets of Protein Kinases

International journal of molecular sciences, 2024-05, Vol.25 (9), p.4725

2024

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An Innovative Approach to Address Neurodegenerative Diseases through Kinase-Targeted Therapies: Potential for Designing Covalent Inhibitors

Pharmaceuticals (Basel, Switzerland), 2023-09, Vol.16 (9), p.1295

2023

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Rational design and synthesis of 2-(1H-indazol-6-yl)-1H-benzo[d]imidazole derivatives as inhibitors targeting FMS-like tyrosine kinase 3 (FLT3) and its mutants

Journal of enzyme inhibition and medicinal chemistry, 2022-12, Vol.37 (1), p.472-486

2022

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Design and Synthesis of Aminopyrimidinyl Pyrazole Analogs as PLK1 Inhibitors Using Hybrid 3D-QSAR and Molecular Docking

Pharmaceuticals (Basel, Switzerland), 2022-09, Vol.15 (10), p.1170

2022

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Discovery of 4-arylamido 3-methyl isoxazole derivatives as novel FMS kinase inhibitors

European journal of medicinal chemistry, 2015-09, Vol.102, p.600-610

2015

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Discovery of a Potent and Selective JNK3 Inhibitor with Neuroprotective Effect Against Amyloid β-Induced Neurotoxicity in Primary Rat Neurons

International journal of molecular sciences, 2021-10, Vol.22 (20), p.11084

2021

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Discovery of 1-Pyrimidinyl-2-Aryl-4,6-Dihydropyrrolo [3,4-d]Imidazole-5(1 H )-Carboxamide as a Novel JNK Inhibitor

International journal of molecular sciences, 2020-03, Vol.21 (5), p.1698

2020

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Design and Synthesis of a Novel PLK1 Inhibitor Scaffold Using a Hybridized 3D-QSAR Model

International journal of molecular sciences, 2021-04, Vol.22 (8), p.3865

2021

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Discovery of 3-alkyl-5-aryl-1-pyrimidyl-1H-pyrazole derivatives as a novel selective inhibitor scaffold of JNK3

Journal of enzyme inhibition and medicinal chemistry, 2020-01, Vol.35 (1), p.372-376

2020

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Computer-aided design and synthesis of 3-carbonyl-5-phenyl-1H-pyrazole as highly selective and potent BRAFV600E and CRAF inhibitor

Journal of enzyme inhibition and medicinal chemistry, 2019-01, Vol.34 (1), p.1314-1320

2019

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Discovery of 5-methyl- N -(2-arylquinazolin-7-yl)isoxazole-4-carboxamide analogues as highly selective FLT3 inhibitors

Journal of enzyme inhibition and medicinal chemistry, 2020-01, Vol.35 (1), p.1110-1115

2020

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Conformational restriction of a type II FMS inhibitor leading to discovery of 5-methyl-N-(2-aryl-1H-benzo[d]imidazo-5-yl)isoxazole-4-carboxamide analogues as selective FLT3 inhibitors

Journal of enzyme inhibition and medicinal chemistry, 2019-01, Vol.34 (1), p.1716-1721

2019

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De Novo Design and Synthesis of a γ-Turn Peptidomimetic Scaffold and Its Application as JNK3 Allosteric Ligand

Chemistry, an Asian journal, 2015-06, Vol.10 (6), p.1318-1326

2015

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Light-Mediated Liberation of Enzymatic Activity: “Small Molecule” Caged Protein Equivalents

Journal of the American Chemical Society, 2008-08, Vol.130 (32), p.10474-10475

2008

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Discovery of N-(5-amido-2-methylphenyl)-5-methylisoxazole-3-carboxamide as dual CSF-1R/c-Kit Inhibitors with improved stability and BBB permeability

European journal of medicinal chemistry, 2024-03, Vol.268, p.116253-116253, Article 116253

2024

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Discovery of highly selective CRAF inhibitors, 3-carboxamido-2H-indazole-6-arylamide: In silico FBLD design, synthesis and evaluation

Bioorganic & medicinal chemistry letters, 2016-02, Vol.26 (4), p.1188-1192

2016

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Novel 1,4,5,6-tetrahydrocyclopenta[d]imidazole-5-carboxamide-based JNK3 inhibitors: Design, synthesis, molecular docking, and therapeutic potential in neurodegenerative diseases

European journal of medicinal chemistry, 2023-01, Vol.245, p.114917, Article 114917

2023

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Targeting the CSF-1/CSF-1R Axis: Exploring the Potential of CSF1R Inhibitors in Neurodegenerative Diseases

Journal of medicinal chemistry, 2024-04, Vol.67 (7), p.5699-5720

2024

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Design of Novel IRAK4 Inhibitors Using Molecular Docking, Dynamics Simulation and 3D-QSAR Studies

Molecules (Basel, Switzerland), 2022-09, Vol.27 (19), p.6307

2022

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Design, synthesis, and in vitro evaluation of N-(3-(3-alkyl-1H-pyrazol-5-yl) phenyl)-aryl amide for selective RAF inhibition

Bioorganic & medicinal chemistry letters, 2019-02, Vol.29 (4), p.534-538

2019

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Carbamate JNK3 Inhibitors Show Promise as Effective Treatments for Alzheimer’s Disease: In Vivo Studies on Mouse Models

Journal of medicinal chemistry, 2023-05, Vol.66 (9), p.6372-6390

2023

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Novel scaffold evolution through combinatorial 3D-QSAR model studies of two types of JNK3 inhibitors

Bioorganic & medicinal chemistry letters, 2017-05, Vol.27 (10), p.2139-2143

2017

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Nec‐1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice

Generation of Non-Nucleotide CD73 Inhibitors Using a Molecular Docking and 3D-QSAR Approach

An Intriguing Purview on the Design of Macrocyclic Inhibitors for Unexplored Protein Kinases through Their Binding Site Comparison

Gaining Insights into Key Structural Hotspots within the Allosteric Binding Pockets of Protein Kinases

An Innovative Approach to Address Neurodegenerative Diseases through Kinase-Targeted Therapies: Potential for Designing Covalent Inhibitors

Rational design and synthesis of 2-(1H-indazol-6-yl)-1H-benzo[d]imidazole derivatives as inhibitors targeting FMS-like tyrosine kinase 3 (FLT3) and its mutants

Design and Synthesis of Aminopyrimidinyl Pyrazole Analogs as PLK1 Inhibitors Using Hybrid 3D-QSAR and Molecular Docking

Discovery of 4-arylamido 3-methyl isoxazole derivatives as novel FMS kinase inhibitors

Discovery of a Potent and Selective JNK3 Inhibitor with Neuroprotective Effect Against Amyloid β-Induced Neurotoxicity in Primary Rat Neurons

Discovery of 1-Pyrimidinyl-2-Aryl-4,6-Dihydropyrrolo [3,4-d]Imidazole-5(1 H )-Carboxamide as a Novel JNK Inhibitor

Design and Synthesis of a Novel PLK1 Inhibitor Scaffold Using a Hybridized 3D-QSAR Model

Discovery of 3-alkyl-5-aryl-1-pyrimidyl-1H-pyrazole derivatives as a novel selective inhibitor scaffold of JNK3

Computer-aided design and synthesis of 3-carbonyl-5-phenyl-1H-pyrazole as highly selective and potent BRAFV600E and CRAF inhibitor

Discovery of 5-methyl- N -(2-arylquinazolin-7-yl)isoxazole-4-carboxamide analogues as highly selective FLT3 inhibitors

Conformational restriction of a type II FMS inhibitor leading to discovery of 5-methyl-N-(2-aryl-1H-benzo[d]imidazo-5-yl)isoxazole-4-carboxamide analogues as selective FLT3 inhibitors

De Novo Design and Synthesis of a γ-Turn Peptidomimetic Scaffold and Its Application as JNK3 Allosteric Ligand

Light-Mediated Liberation of Enzymatic Activity: “Small Molecule” Caged Protein Equivalents

Discovery of N-(5-amido-2-methylphenyl)-5-methylisoxazole-3-carboxamide as dual CSF-1R/c-Kit Inhibitors with improved stability and BBB permeability

Discovery of highly selective CRAF inhibitors, 3-carboxamido-2H-indazole-6-arylamide: In silico FBLD design, synthesis and evaluation

Novel 1,4,5,6-tetrahydrocyclopenta[d]imidazole-5-carboxamide-based JNK3 inhibitors: Design, synthesis, molecular docking, and therapeutic potential in neurodegenerative diseases

Targeting the CSF-1/CSF-1R Axis: Exploring the Potential of CSF1R Inhibitors in Neurodegenerative Diseases

Design of Novel IRAK4 Inhibitors Using Molecular Docking, Dynamics Simulation and 3D-QSAR Studies

Design, synthesis, and in vitro evaluation of N-(3-(3-alkyl-1H-pyrazol-5-yl) phenyl)-aryl amide for selective RAF inhibition

Carbamate JNK3 Inhibitors Show Promise as Effective Treatments for Alzheimer’s Disease: In Vivo Studies on Mouse Models

Novel scaffold evolution through combinatorial 3D-QSAR model studies of two types of JNK3 inhibitors

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