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Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation

The Journal of clinical investigation, 2020-04, Vol.130 (4), p.2041-2053

2020

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4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation

Journal of medicinal chemistry, 2019-09, Vol.62 (17), p.8330-8337

2019

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Small-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide

Journal of the American Society of Nephrology, 2016-12, Vol.27 (12), p.3706-3714

2016

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A small molecule inhibitor of the chloride channel TMEM16A blocks vascular smooth muscle contraction and lowers blood pressure in spontaneously hypertensive rats

Kidney international, 2021-08, Vol.100 (2), p.311-320

2021

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Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product

The Journal of biological chemistry, 2017-01, Vol.292 (3), p.771-785

2017

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Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action

European journal of medicinal chemistry, 2023-03, Vol.249, p.115149-115149, Article 115149

2023

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Nanomolar-potency ‘co-potentiator’ therapy for cystic fibrosis caused by a defined subset of minimal function CFTR mutants

Scientific reports, 2019-11, Vol.9 (1), p.17640-12, Article 17640

2019

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X-box binding protein 1 (XBP1s) is a critical determinant of Pseudomonas aeruginosa homoserine lactone-mediated apoptosis

PLoS pathogens, 2013-08, Vol.9 (8), p.e1003576

2013

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Cystic Fibrosis Transmembrane Conductance Regulator-independent Phagosomal Acidification in Macrophages

The Journal of biological chemistry, 2007-10, Vol.282 (43), p.31422-31428

2007

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Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis

The FASEB journal, 2016-06, Vol.30 (6), p.2187-2197

2016

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A simple method to generate human airway epithelial organoids with externally orientated apical membranes

American journal of physiology. Lung cellular and molecular physiology, 2022-03, Vol.322 (3), p.L420-L437

2022

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Small-molecule inhibitor of intestinal anion exchanger SLC26A3 for treatment of hyperoxaluria and nephrolithiasis

JCI insight, 2022-07, Vol.7 (13)

2022

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Combination potentiator (‘co-potentiator’) therapy for CF caused by CFTR mutants, including N1303K, that are poorly responsive to single potentiators

Journal of cystic fibrosis, 2018-09, Vol.17 (5), p.595-606

2018

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Tracking of quantum dot-labeled CFTR shows near immobilization by C-terminal PDZ interactions

Molecular biology of the cell, 2006-12, Vol.17 (12), p.4937-4945

2006

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1-BENZYLSPIRO[PIPERIDINE-4,1′-PYRIDO[3,4-b]indole] ‘co-potentiators’ for minimal function CFTR mutants

European journal of medicinal chemistry, 2021-01, Vol.209, p.112888-112888, Article 112888

2021

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Single-Particle Tracking of Membrane Protein Diffusion in a Potential: Simulation, Detection, and Application to Confined Diffusion of CFTR Cl − Channels

Biophysical journal, 2007-08, Vol.93 (3), p.1079-1088

2007

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Selective isoxazolopyrimidine PAT1 (SLC26A6) inhibitors for therapy of intestinal disorders

RSC medicinal chemistry, 2023-11, Vol.14 (11), p.2342-2347

2023

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Unimpaired Lysosomal Acidification in Respiratory Epithelial Cells in Cystic Fibrosis

The Journal of biological chemistry, 2009-03, Vol.284 (12), p.7681-7686

2009

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CFTR modulator therapy for cystic fibrosis caused by the rare c.3700A>G mutation

Journal of cystic fibrosis, 2021-05, Vol.20 (3), p.452-459

2021

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Towards next generation therapies for cystic fibrosis: Folding, function and pharmacology of CFTR

Journal of cystic fibrosis, 2020-03, Vol.19 (Suppl 1), p.S25-S32

2020

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Defective organellar acidification as a cause of cystic fibrosis lung disease: reexamination of a recurring hypothesis

American journal of physiology. Lung cellular and molecular physiology, 2009-06, Vol.296 (6), p.L859-L867

2009

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Green fluorescent protein-based halide indicators with improved chloride and iodide affinities

FEBS letters, 2001-06, Vol.499 (3), p.220-224

2001

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SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation

JCI insight, 2018-07, Vol.3 (14)

2018

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Correction: X-Box Binding Protein 1 (XBP1s) Is a Critical Determinant of Pseudomonas aeruginosa Homoserine Lactone-Mediated Apoptosis

PLoS pathogens, 2016-05, Vol.12 (5), p.e1005628-e1005628

2016

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Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation

4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation

Small-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide

A small molecule inhibitor of the chloride channel TMEM16A blocks vascular smooth muscle contraction and lowers blood pressure in spontaneously hypertensive rats

Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product

Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action

Nanomolar-potency ‘co-potentiator’ therapy for cystic fibrosis caused by a defined subset of minimal function CFTR mutants

X-box binding protein 1 (XBP1s) is a critical determinant of Pseudomonas aeruginosa homoserine lactone-mediated apoptosis

Cystic Fibrosis Transmembrane Conductance Regulator-independent Phagosomal Acidification in Macrophages

Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis

Transgenic ferret models define pulmonary ionocyte diversity and function

A simple method to generate human airway epithelial organoids with externally orientated apical membranes

Small-molecule inhibitor of intestinal anion exchanger SLC26A3 for treatment of hyperoxaluria and nephrolithiasis

Combination potentiator (‘co-potentiator’) therapy for CF caused by CFTR mutants, including N1303K, that are poorly responsive to single potentiators

Tracking of quantum dot-labeled CFTR shows near immobilization by C-terminal PDZ interactions

1-BENZYLSPIRO[PIPERIDINE-4,1′-PYRIDO[3,4-b]indole] ‘co-potentiators’ for minimal function CFTR mutants

Single-Particle Tracking of Membrane Protein Diffusion in a Potential: Simulation, Detection, and Application to Confined Diffusion of CFTR Cl − Channels

Selective isoxazolopyrimidine PAT1 (SLC26A6) inhibitors for therapy of intestinal disorders

Unimpaired Lysosomal Acidification in Respiratory Epithelial Cells in Cystic Fibrosis

CFTR modulator therapy for cystic fibrosis caused by the rare c.3700A>G mutation

Towards next generation therapies for cystic fibrosis: Folding, function and pharmacology of CFTR

Defective organellar acidification as a cause of cystic fibrosis lung disease: reexamination of a recurring hypothesis

Green fluorescent protein-based halide indicators with improved chloride and iodide affinities

SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation

Correction: X-Box Binding Protein 1 (XBP1s) Is a Critical Determinant of Pseudomonas aeruginosa Homoserine Lactone-Mediated Apoptosis

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