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Advances in Bacterial Methionine Aminopeptidase Inhibition

Current topics in medicinal chemistry, 2016-01, Vol.16 (4), p.397

2016

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Novel inhibitors of Rickettsia prowazekii methionine aminopeptidase from the Malaria Box

Bioorganic & medicinal chemistry letters, 2023-05, Vol.87, p.129281-129281, Article 129281

2023

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Demonstration of AutoDock as an Educational Tool for Drug Discovery

Journal of chemical education, 2017-03, Vol.94 (3), p.345-349

2017

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Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders

Journal of medicinal chemistry, 2019-05, Vol.62 (10), p.4884-4901

2019

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The synthesis, antimalarial activity and CoMFA analysis of novel aminoalkylated quercetin analogs

Bioorganic & medicinal chemistry letters, 2015-01, Vol.25 (2), p.327-332

2015

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Structural Characterization of the Reaction and Substrate Specificity Mechanisms of Pathogenic Fungal Acetyl-CoA Synthetases

ACS chemical biology, 2021-08, Vol.16 (8), p.1587-1599

2021

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Bacterial structural genomics target enabled by a recently discovered potent fungal acetyl‐CoA synthetase inhibitor

Acta crystallographica. Section F, Structural biology communications, 2023-06, Vol.79 (6), p.137-143

2023

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Structural and biophysical characterization of the Burkholderia pseudomallei IspF inhibitor L-tryptophan hydroxamate

Bioorganic & medicinal chemistry letters, 2021-09, Vol.48, p.128273-128273, Article 128273

2021

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Discovery of triazines as selective PDE4B versus PDE4D inhibitors

Bioorganic & medicinal chemistry letters, 2014-08, Vol.24 (16), p.4031-4034

2014

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Traditional Kenyan herbal medicine: exploring natural products’ therapeutics against schistosomiasis

Journal of helminthology, 2022-03, Vol.96, p.e16-e16, Article e16

2022

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Compound D159687, a phosphodiesterase 4D inhibitor, induces weight and fat mass loss in aged mice without changing lean mass, physical and cognitive function

Biochemical and biophysical research communications, 2018-12, Vol.506 (4), p.1059-1064

2018

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Antibacterial activity of 2-amino-4-hydroxypyrimidine-5-carboxylates and binding to Burkholderia pseudomallei 2-C-methyl-d-erythritol-2,4-cyclodiphosphate synthase

Bioorganic & medicinal chemistry letters, 2019-10, Vol.29 (20), p.126660-126660, Article 126660

2019

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Crystal structure and biophysical characterization of IspD from Burkholderia thailandensis and Mycobacterium paratuberculosis

Acta crystallographica. Section F, Structural biology communications, 2024-02, Vol.80 (2), p.43-51

2024

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A concise synthesis of biaryl PDE4D allosteric modulators

Tetrahedron letters, 2013-05, Vol.54 (21), p.2737-2739

2013

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Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents

Bioorganic & medicinal chemistry, 2017-02, Vol.25 (3), p.813-824

2017

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The identification of inhibitory compounds of Rickettsia prowazekii methionine aminopeptidase for antibacterial applications

Bioorganic & medicinal chemistry letters, 2018-05, Vol.28 (8), p.1376-1380

2018

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Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents

Bioorganic & medicinal chemistry letters, 2015-12, Vol.25 (24), p.5699-5704

2015

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Cytidine derivatives as IspF inhibitors of Burkolderia pseudomallei

Bioorganic & medicinal chemistry letters, 2013-12, Vol.23 (24), p.6860-6863

2013

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Discovery of Inhibitors of Burkholderia pseudomallei Methionine Aminopeptidase with Antibacterial Activity

ACS medicinal chemistry letters, 2013-08, Vol.4 (8), p.699-703

2013

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Predictive binding of .beta.-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach

Journal of medicinal chemistry, 1992-10, Vol.35 (22), p.4001-4010

1992

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Synthesis of novel 3-substituted .beta.-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore

Journal of medicinal chemistry, 1988-09, Vol.31 (9), p.1854-1861

1988

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DDQ oxidations in the indole area. Synthesis of 4-alkoxy-.beta.-carbolines including the natural products crenatine and 1-methoxycanthin-6-one

Journal of organic chemistry, 1989-04, Vol.54 (9), p.2170-2178

1989

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2,4-disubstituted oxazoles and thiazoles as latent pharmacophores for diacylhydrazine of SC-51089, a potent PGE2 antagonist

Bioorganic & medicinal chemistry, 2001, Vol.9 (1), p.1-6

2001

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5-Fluorinated l-Lysine Analogues as Selective Induced Nitric Oxide Synthase Inhibitors

Journal of medicinal chemistry, 2004-02, Vol.47 (4), p.900-906

2004

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2-Iminopyrrolidines as Potent and Selective Inhibitors of Human Inducible Nitric Oxide Synthase

Journal of medicinal chemistry, 1998-09, Vol.41 (19), p.3675-3683

1998

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Advances in Bacterial Methionine Aminopeptidase Inhibition

Novel inhibitors of Rickettsia prowazekii methionine aminopeptidase from the Malaria Box

Demonstration of AutoDock as an Educational Tool for Drug Discovery

Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders

The synthesis, antimalarial activity and CoMFA analysis of novel aminoalkylated quercetin analogs

Structural Characterization of the Reaction and Substrate Specificity Mechanisms of Pathogenic Fungal Acetyl-CoA Synthetases

Bacterial structural genomics target enabled by a recently discovered potent fungal acetyl‐CoA synthetase inhibitor

Structural and biophysical characterization of the Burkholderia pseudomallei IspF inhibitor L-tryptophan hydroxamate

Discovery of triazines as selective PDE4B versus PDE4D inhibitors

Traditional Kenyan herbal medicine: exploring natural products’ therapeutics against schistosomiasis

Compound D159687, a phosphodiesterase 4D inhibitor, induces weight and fat mass loss in aged mice without changing lean mass, physical and cognitive function

Antibacterial activity of 2-amino-4-hydroxypyrimidine-5-carboxylates and binding to Burkholderia pseudomallei 2-C-methyl-d-erythritol-2,4-cyclodiphosphate synthase

Crystal structure and biophysical characterization of IspD from Burkholderia thailandensis and Mycobacterium paratuberculosis

A concise synthesis of biaryl PDE4D allosteric modulators

Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents

The identification of inhibitory compounds of Rickettsia prowazekii methionine aminopeptidase for antibacterial applications

Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents

Cytidine derivatives as IspF inhibitors of Burkolderia pseudomallei

Discovery of Inhibitors of Burkholderia pseudomallei Methionine Aminopeptidase with Antibacterial Activity

Predictive binding of .beta.-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach

Synthesis of novel 3-substituted .beta.-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore

DDQ oxidations in the indole area. Synthesis of 4-alkoxy-.beta.-carbolines including the natural products crenatine and 1-methoxycanthin-6-one

2,4-disubstituted oxazoles and thiazoles as latent pharmacophores for diacylhydrazine of SC-51089, a potent PGE2 antagonist

5-Fluorinated l-Lysine Analogues as Selective Induced Nitric Oxide Synthase Inhibitors

2-Iminopyrrolidines as Potent and Selective Inhibitors of Human Inducible Nitric Oxide Synthase

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