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Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction

Urology (Ridgewood, N.J.), 2000-10, Vol.56 (4), p.641-646

2000

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Discovery that a melanocortin regulates sexual functions in male and female humans

Peptides (New York, N.Y. : 1980), 2005-10, Vol.26 (10), p.1687-1689

Hadley, Mac E.

2005

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Melanocortin peptide therapeutics: Historical milestones, clinical studies and commercialization

Peptides (New York, N.Y. : 1980), 2006-04, Vol.27 (4), p.921-930

2006

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Discovery of Prototype Peptidomimetic Agonists at the Human Melanocortin Receptors MC1R and MC4R

Journal of medicinal chemistry, 1997-07, Vol.40 (14), p.2133-2139

1997

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Potent and prolonged-acting cyclic lactam analogs of .alpha.-melanotropin: design based on molecular dynamics

Journal of medicinal chemistry, 1989-12, Vol.32 (12), p.2555-2561

1989

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The Proopiomelanocortin System

Annals of the New York Academy of Sciences, 1999-10, Vol.885 (1), p.1-21

1999

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Melanotropic Peptide-Conjugated Beads for Microscopic Visualization and Characterization of Melanoma Melanotropin Receptors

Proceedings of the National Academy of Sciences - PNAS, 1996-11, Vol.93 (24), p.13715-13720

1996

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Design of a new class of superpotent cyclic .alpha.-melanotropins based on quenched dynamic simulations

Journal of the American Chemical Society, 1989-04, Vol.111 (9), p.3413-3416

1989

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alpha.-Melanotropin: the minimal active sequence in the frog skin bioassay

Journal of medicinal chemistry, 1987-11, Vol.30 (11), p.2126-2130

1987

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De Novo Design, Synthesis, and Pharmacology of α-Melanocyte Stimulating Hormone Analogues Derived from Somatostatin by a Hybrid Approach

Journal of medicinal chemistry, 2004-03, Vol.47 (6), p.1514-1526

2004

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Induction of skin tanning by subcutaneous administration of a potent synthetic melanotropin

JAMA : the journal of the American Medical Association, 1991-11, Vol.266 (19), p.2730

1991

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Synthesis and biological activities of fatty acid conjugates of a cyclic lactam .alpha.-melanotropin

Journal of medicinal chemistry, 1992-01, Vol.35 (1), p.118-123

1992

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Characterizations of the Unusual Dissociation Properties of Melanotropin Peptides from the Melanocortin Receptor, hMC1R

Journal of medicinal chemistry, 1996-01, Vol.39 (2), p.432-435

1996

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Topographical modification of melanotropin peptide analogs with .beta.-methyltryptophan isomers at position 9 leads to differential potencies and prolonged biological activities

Journal of medicinal chemistry, 1995-11, Vol.38 (23), p.4720-4729

1995

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Pharmacologic response of a controlled-release PLGA formulation for the alpha-melanocyte stimulating hormone analog, Melanotan-I

Pharmaceutical research, 2000-05, Vol.17 (5), p.593-599

2000

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Biogenic Amines and Control of Melanophore Stimulating Hormone Release

Science (American Association for the Advancement of Science), 1974-04, Vol.184 (4132), p.70-72

1974

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SYNTHETIC MELANOTROPIC PEPTIDE INITIATES ERECTIONS IN MEN WITH PSYCHOGENIC ERECTILE DYSFUNCTION: DOUBLE-BLIND, PLACEBO CONTROLLED CROSSOVER STUDY

The Journal of urology, 1998-08, Vol.160 (2), p.389-393

1998

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Structure-activity correlations of melanotropin peptides in model lipids by tryptophan fluorescence studies

Biochemistry (Easton), 1993-11, Vol.32 (45), p.12264-12272

1993

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Design, Synthesis, Biology, and Conformations of Bicyclic .alpha.-Melanotropin Analogs

Journal of medicinal chemistry, 1995-05, Vol.38 (10), p.1736-1750

1995

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Multivalent Melanotropic Peptide and Fluorescent Macromolecular Conjugates: New Reagents for Characterization of Melanotropin Receptors

Bioconjugate chemistry, 1994-11, Vol.5 (6), p.591-601

1994

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β-Methylation of the Phe7 and Trp9 Melanotropin Side Chain Pharmacophores Affects Ligand−Receptor Interactions and Prolonged Biological Activity

Journal of medicinal chemistry, 1997-08, Vol.40 (17), p.2740-2749

1997

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Design and bioactivities of melanotropic peptide agonists and antagonists: Design based on a conformationally constrained somatostatin template

International journal of peptide research and therapeutics, 1998-05, Vol.5 (2-3), p.117-120

1998

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[1-Penicillamine,2-leucine]oxytocin. Synthesis and pharmacological and conformational studies of a potent peptide hormone inhibitor

Journal of medicinal chemistry, 1979-01, Vol.22 (1), p.7-12

1979

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Cyclic lactam analogs of Ac-[Nle4].alpha.-MSH4-11-NH2

Biochemistry (Easton), 1988-10, Vol.27 (21), p.8181-8188

1988

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Cyclic lactam .alpha.-melanotropin analogs of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10]-.alpha.-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors

Journal of medicinal chemistry, 1995-09, Vol.38 (18), p.3454-3461

1995

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Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction

Discovery that a melanocortin regulates sexual functions in male and female humans

Melanocortin peptide therapeutics: Historical milestones, clinical studies and commercialization

Discovery of Prototype Peptidomimetic Agonists at the Human Melanocortin Receptors MC1R and MC4R

Potent and prolonged-acting cyclic lactam analogs of .alpha.-melanotropin: design based on molecular dynamics

The Proopiomelanocortin System

Melanotropic Peptide-Conjugated Beads for Microscopic Visualization and Characterization of Melanoma Melanotropin Receptors

Design of a new class of superpotent cyclic .alpha.-melanotropins based on quenched dynamic simulations

alpha.-Melanotropin: the minimal active sequence in the frog skin bioassay

De Novo Design, Synthesis, and Pharmacology of α-Melanocyte Stimulating Hormone Analogues Derived from Somatostatin by a Hybrid Approach

Induction of skin tanning by subcutaneous administration of a potent synthetic melanotropin

Synthesis and biological activities of fatty acid conjugates of a cyclic lactam .alpha.-melanotropin

Characterizations of the Unusual Dissociation Properties of Melanotropin Peptides from the Melanocortin Receptor, hMC1R

Topographical modification of melanotropin peptide analogs with .beta.-methyltryptophan isomers at position 9 leads to differential potencies and prolonged biological activities

Pharmacologic response of a controlled-release PLGA formulation for the alpha-melanocyte stimulating hormone analog, Melanotan-I

Biogenic Amines and Control of Melanophore Stimulating Hormone Release

SYNTHETIC MELANOTROPIC PEPTIDE INITIATES ERECTIONS IN MEN WITH PSYCHOGENIC ERECTILE DYSFUNCTION: DOUBLE-BLIND, PLACEBO CONTROLLED CROSSOVER STUDY

Structure-activity correlations of melanotropin peptides in model lipids by tryptophan fluorescence studies

Design, Synthesis, Biology, and Conformations of Bicyclic .alpha.-Melanotropin Analogs

Multivalent Melanotropic Peptide and Fluorescent Macromolecular Conjugates: New Reagents for Characterization of Melanotropin Receptors

β-Methylation of the Phe7 and Trp9 Melanotropin Side Chain Pharmacophores Affects Ligand−Receptor Interactions and Prolonged Biological Activity

Design and bioactivities of melanotropic peptide agonists and antagonists: Design based on a conformationally constrained somatostatin template

[1-Penicillamine,2-leucine]oxytocin. Synthesis and pharmacological and conformational studies of a potent peptide hormone inhibitor

Cyclic lactam analogs of Ac-[Nle4].alpha.-MSH4-11-NH2

Cyclic lactam .alpha.-melanotropin analogs of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10]-.alpha.-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors

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