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HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis

Molecular cell, 2020-06, Vol.78 (6), p.1237-1251.e7

2020

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Methyllysine binding domains: Structural insight and small molecule probe development

European journal of medicinal chemistry, 2017-08, Vol.136, p.14-35

2017

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Inhibition of hedgehog signaling by stereochemically defined des-triazole itraconazole analogues

Bioorganic & medicinal chemistry letters, 2020-01, Vol.30 (2), p.126794-126794, Article 126794

2020

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Probing the Protein-Protein Interaction between the ATRXADD Domain and the Histone H3 Tail

Molecules (Basel, Switzerland), 2020-03, Vol.25 (7), p.1500

2020

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Inhibition of the translesion synthesis polymerase REV1 exploits replication gaps as a cancer vulnerability

Science advances, 2020-06, Vol.6 (24), p.eaaz7808-eaaz7808

2020

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Small molecules block the interaction between porcine reproductive and respiratory syndrome virus and CD163 receptor and the infection of pig cells

Virology journal, 2020-07, Vol.17 (1), p.1-116, Article 116

2020

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Exploring the physicochemical and antiproliferative properties of biaryl-linked [13]-macrodilactones

Bioorganic & medicinal chemistry, 2020-10, Vol.28 (20), p.115671-115671, Article 115671

2020

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REV1 Inhibition Enhances Radioresistance and Autophagy

Cancers, 2021-10, Vol.13 (21), p.5290

2021

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Structure‐Based Drug Design of Phenazopyridine Derivatives as Inhibitors of Rev1 Interactions in Translesion Synthesis

ChemMedChem, 2021-04, Vol.16 (7), p.1126-1132

2021

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Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold

Bioorganic & medicinal chemistry, 2009-01, Vol.17 (2), p.634-640

2009

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Evaluation of vitamin D3 A-ring analogues as Hedgehog pathway inhibitors

Bioorganic & medicinal chemistry letters, 2012-02, Vol.22 (3), p.1330-1334

2012

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Virtual Pharmacophore Screening Identifies Small‐Molecule Inhibitors of the Rev1‐CT/RIR Protein–Protein Interaction

ChemMedChem, 2019-09, Vol.14 (17), p.1610-1617

2019

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Probing the structural requirements for vitamin D3 inhibition of the hedgehog signaling pathway

Bioorganic & medicinal chemistry letters, 2012-07, Vol.22 (14), p.4859-4863

2012

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Oncoepigenomics: Making histone lysine methylation count

European journal of medicinal chemistry, 2012-10, Vol.56, p.179-194

2012

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Vitamin D3 analogues that contain modified A- and seco-B-rings as hedgehog pathway inhibitors

European journal of medicinal chemistry, 2015-03, Vol.93, p.156-171

2015

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Medulloblastoma drugs in development: Current leads, trials and drawbacks

European journal of medicinal chemistry, 2021-04, Vol.215, p.113268-113268, Article 113268

2021

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Translesion DNA synthesis mediates acquired resistance to olaparib plus temozolomide in small cell lung cancer

Science advances, 2022-05, Vol.8 (19), p.eabn1229

2022

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Targeting the fibroblast growth factor receptors for the treatment of cancer

Anti-cancer agents in medicinal chemistry, 2013-06, Vol.13 (5), p.748-761

2013

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Affinity-based protein profiling identifies vitamin D3 as a heat shock protein 70 antagonist that regulates hedgehog transduction in murine basal cell carcinoma

European journal of medicinal chemistry, 2022-01, Vol.228, p.114005-114005, Article 114005

2022

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Structure-based virtual screening identifies an 8-hydroxyquinoline as a small molecule GLI1 inhibitor

Molecular therapy. Oncolytics, 2021-03, Vol.20, p.265-276

2021

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Small molecules that regulate the N6-methyladenosine RNA modification as potential anti-cancer agents

European journal of medicinal chemistry, 2024-08, Vol.274, p.116526, Article 116526

2024

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Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer Chemotherapeutics

Journal of medicinal chemistry, 2016-10, Vol.59 (20), p.9321-9336

2016

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Derrubone, an Inhibitor of the Hsp90 Protein Folding Machinery

Journal of natural products (Washington, D.C.), 2007-12, Vol.70 (12), p.2014-2018

2007

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Translesion synthesis inhibitors as a new class of cancer chemotherapeutics

Expert opinion on investigational drugs, 2021-01, Vol.30 (1), p.13-24

2021

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Identification of Small Molecule Hes1 Modulators as Potential Anticancer Chemotherapeutics

Chemical biology & drug design, 2013-03, Vol.81 (3), p.334-342

2013

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HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis

Methyllysine binding domains: Structural insight and small molecule probe development

Inhibition of hedgehog signaling by stereochemically defined des-triazole itraconazole analogues

Probing the Protein-Protein Interaction between the ATRXADD Domain and the Histone H3 Tail

Inhibition of the translesion synthesis polymerase REV1 exploits replication gaps as a cancer vulnerability

Small molecules block the interaction between porcine reproductive and respiratory syndrome virus and CD163 receptor and the infection of pig cells

Exploring the physicochemical and antiproliferative properties of biaryl-linked [13]-macrodilactones

REV1 Inhibition Enhances Radioresistance and Autophagy

Structure‐Based Drug Design of Phenazopyridine Derivatives as Inhibitors of Rev1 Interactions in Translesion Synthesis

Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold

Evaluation of vitamin D3 A-ring analogues as Hedgehog pathway inhibitors

Virtual Pharmacophore Screening Identifies Small‐Molecule Inhibitors of the Rev1‐CT/RIR Protein–Protein Interaction

Probing the structural requirements for vitamin D3 inhibition of the hedgehog signaling pathway

Oncoepigenomics: Making histone lysine methylation count

Vitamin D3 analogues that contain modified A- and seco-B-rings as hedgehog pathway inhibitors

Medulloblastoma drugs in development: Current leads, trials and drawbacks

Translesion DNA synthesis mediates acquired resistance to olaparib plus temozolomide in small cell lung cancer

Targeting the fibroblast growth factor receptors for the treatment of cancer

Affinity-based protein profiling identifies vitamin D3 as a heat shock protein 70 antagonist that regulates hedgehog transduction in murine basal cell carcinoma

Structure-based virtual screening identifies an 8-hydroxyquinoline as a small molecule GLI1 inhibitor

Small molecules that regulate the N6-methyladenosine RNA modification as potential anti-cancer agents

Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer Chemotherapeutics

Derrubone, an Inhibitor of the Hsp90 Protein Folding Machinery

Translesion synthesis inhibitors as a new class of cancer chemotherapeutics

Identification of Small Molecule Hes1 Modulators as Potential Anticancer Chemotherapeutics

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