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EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction

Nature communications, 2021-02, Vol.12 (1), p.986-11, Article 986

2021

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Protein Conformational Switches: From Nature to Design

Chemistry : a European journal, 2012-06, Vol.18 (26), p.7984-7999

2012

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A generalizable nanopore sensor for highly specific protein detection at single-molecule precision

Nature communications, 2023-03, Vol.14 (1), p.1374-1374, Article 1374

2023

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Zinc shapes the folding landscape of p53 and establishes a pathway for reactivating structurally diverse cancer mutants

eLife, 2020-12, Vol.9

2020

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Large enhancement of response times of a protein conformational switch by computational design

Nature communications, 2018-03, Vol.9 (1), p.1013-9, Article 1013

2018

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Enhancing response of a protein conformational switch by using two disordered ligand binding domains

Frontiers in molecular biosciences, 2023-03, Vol.10, p.1114756-1114756

2023

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Small Molecule-Induced Domain Swapping as a Mechanism for Controlling Protein Function and Assembly

Scientific reports, 2017-03, Vol.7 (1), p.44388-44388, Article 44388

2017

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p53 and Zinc: A Malleable Relationship

Frontiers in molecular biosciences, 2022-04, Vol.9, p.895887-895887

2022

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Engineering protein and DNA tools for creating DNA-dependent protein switches

Methods in enzymology, 2022, Vol.675, p.1-32

2022

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Loss of bound zinc facilitates amyloid fibril formation of leukocyte-cell-derived chemotaxin 2 (LECT2)

The Journal of biological chemistry, 2021-01, Vol.296, p.100446-100446, Article 100446

2021

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Mimicking kidney flow shear efficiently induces aggregation of LECT2, a protein involved in renal amyloidosis

The Journal of biological chemistry, 2024-05, Vol.300 (5), p.107231-107231, Article 107231

2024

Volltextzugriff (PDF)

Insertion state of modular protein nanopores into a membrane

Biochimica et biophysica acta. Biomembranes, 2021-05, Vol.1863 (5), p.183570-183570, Article 183570

2021

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A Single Protein Disruption Site Results in Efficient Reassembly by Multiple Engineering Methods

Biophysical journal, 2019-07, Vol.117 (1), p.56-65

2019

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Adaptable, turn-on maturation (ATOM) fluorescent biosensors for multiplexed detection in cells

Nature methods, 2023-12, Vol.20 (12), p.1920

2023

Volltextzugriff (PDF)

Construction of Allosteric Protein Switches by Alternate Frame Folding and Intermolecular Fragment Exchange

Methods in molecular biology (Clifton, N.J.), 2017, Vol.1596, p.27

2017

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Probing local structural fluctuations in myoglobin by size‐dependent thiol‐disulfide exchange

Protein science, 2010-08, Vol.19 (8), p.1587-1594

2010

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Engineering a Fluorescent Protein Color Switch Using Entropy-Driven β‑Strand Exchange

ACS sensors, 2022-01, Vol.7 (1), p.263-271

2022

Volltextzugriff (PDF)

Discovery of a novel SHIP1 agonist that promotes degradation of lipid-laden phagocytic cargo by microglia

iScience, 2022-04, Vol.25 (4), p.104170-104170, Article 104170

2022

Volltextzugriff (PDF)

Stepwise Conversion of a Binding Protein to a Fluorescent Switch: Application to Thermoanaerobacter tengcongensis Ribose Binding Protein

Biochemistry (Easton), 2013-01, Vol.52 (4), p.600-612

2013

Volltextzugriff (PDF)

Urea Denaturation, Zinc Binding, and DNA Binding Assays of Mutant p53 DNA-binding Domains and Full-length Proteins

Bio-protocol, 2021-10, Vol.11 (20), p.e4188-e4188

2021

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Engineering Domain-Swapped Binding Interfaces by Mutually Exclusive Folding

Journal of molecular biology, 2012-03, Vol.416 (4), p.495-502

2012

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Changes in side chain packing during apomyoglobin folding characterized by pulsed thiol-disulfide exchange

Nature structural & molecular biology, 1998-08, Vol.5 (8), p.730-737

1998

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Role of the hydrophobic effect in stability of site-specific protein-DNA complexes

Journal of molecular biology, 1989-10, Vol.209 (4), p.801-816

1989

Volltextzugriff (PDF)

Thermodynamic stoichiometries of participation of water, cations and anions in specific and non-specific binding of lac repressor to DNA : Possible thermodynamic origins of the “glutamate effect” on protein-DNA interactions

Journal of molecular biology, 1992-11, Vol.228 (1), p.252-264

1992

Volltextzugriff (PDF)

Allosteric Switching by Mutually Exclusive Folding of Protein Domains

Journal of molecular biology, 2003-09, Vol.332 (3), p.529-536

2003

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EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction

Protein Conformational Switches: From Nature to Design

A generalizable nanopore sensor for highly specific protein detection at single-molecule precision

Zinc shapes the folding landscape of p53 and establishes a pathway for reactivating structurally diverse cancer mutants

Large enhancement of response times of a protein conformational switch by computational design

Enhancing response of a protein conformational switch by using two disordered ligand binding domains

Small Molecule-Induced Domain Swapping as a Mechanism for Controlling Protein Function and Assembly

p53 and Zinc: A Malleable Relationship

Engineering protein and DNA tools for creating DNA-dependent protein switches

Loss of bound zinc facilitates amyloid fibril formation of leukocyte-cell-derived chemotaxin 2 (LECT2)

Mimicking kidney flow shear efficiently induces aggregation of LECT2, a protein involved in renal amyloidosis

Insertion state of modular protein nanopores into a membrane

A Single Protein Disruption Site Results in Efficient Reassembly by Multiple Engineering Methods

Adaptable, turn-on maturation (ATOM) fluorescent biosensors for multiplexed detection in cells

Construction of Allosteric Protein Switches by Alternate Frame Folding and Intermolecular Fragment Exchange

Probing local structural fluctuations in myoglobin by size‐dependent thiol‐disulfide exchange

Engineering a Fluorescent Protein Color Switch Using Entropy-Driven β‑Strand Exchange

Discovery of a novel SHIP1 agonist that promotes degradation of lipid-laden phagocytic cargo by microglia

Stepwise Conversion of a Binding Protein to a Fluorescent Switch: Application to Thermoanaerobacter tengcongensis Ribose Binding Protein

Urea Denaturation, Zinc Binding, and DNA Binding Assays of Mutant p53 DNA-binding Domains and Full-length Proteins

Engineering Domain-Swapped Binding Interfaces by Mutually Exclusive Folding

Changes in side chain packing during apomyoglobin folding characterized by pulsed thiol-disulfide exchange

Role of the hydrophobic effect in stability of site-specific protein-DNA complexes

Thermodynamic stoichiometries of participation of water, cations and anions in specific and non-specific binding of lac repressor to DNA : Possible thermodynamic origins of the “glutamate effect” on protein-DNA interactions

Allosteric Switching by Mutually Exclusive Folding of Protein Domains

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