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Induced protein degradation of anaplastic lymphoma kinase (ALK) by proteolysis targeting chimera (PROTAC)

Biochemical and biophysical research communications, 2018-10, Vol.505 (2), p.542-547

2018

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Design and characterization of cereblon-mediated androgen receptor proteolysis-targeting chimeras

European journal of medicinal chemistry, 2020-12, Vol.208, p.112769-112769, Article 112769

2020

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Combination Treatment with GSK126 and Pomalidomide Induces B-Cell Differentiation in EZH2 Gain-of-Function Mutant Diffuse Large B-Cell Lymphoma

Cancers, 2020-09, Vol.12 (9), p.2541

2020

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Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors

Bioorganic & medicinal chemistry letters, 2006-06, Vol.16 (11), p.2996-2999

2006

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Augmentation of the antitumor effects of PARP inhibitors in triple-negative breast cancer via degradation by hydrophobic tagging modulation

European journal of medicinal chemistry, 2020-10, Vol.204, p.112635-112635, Article 112635

2020

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Cereblon contributes to cardiac dysfunction by degrading Cav1.2α

European heart journal, 2022-05, Vol.43 (20), p.1973-1989

2022

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New Pyrimidine Derivatives possessing ALK Inhibitory Activities

Bulletin of the Korean Chemical Society, 2013, 34(10), , pp.3129-3132

2013

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Synthesis and structure–activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors

Bioorganic & medicinal chemistry letters, 2012-06, Vol.22 (12), p.4044-4048

2012

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A Novel Series of Highly Potent Small Molecule Inhibitors of Rhinovirus Replication

Journal of medicinal chemistry, 2017-07, Vol.60 (13), p.5472-5492

2017

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Discovery of aminopyridines substituted with benzoxazole as orally active c-Met kinase inhibitors

Bioorganic & medicinal chemistry letters, 2010-07, Vol.20 (14), p.4223-4227

2010

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Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera

Scientific reports, 2019-12, Vol.9 (1), p.19654-14, Article 19654

2019

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Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors

Bioorganic & medicinal chemistry letters, 2017-09, Vol.27 (18), p.4399-4404

2017

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Design and synthesis of triazolopyridazines substituted with methylisoquinolinone as selective c-Met kinase inhibitors

Bioorganic & medicinal chemistry letters, 2011-12, Vol.21 (23), p.7185-7188

2011

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Replacing the terminal piperidine in ceritinib with aliphatic amines confers activities against crizotinib-resistant mutants including G1202R

European journal of medicinal chemistry, 2017-01, Vol.126, p.536-549

2017

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cIAPs promote the proteasomal degradation of mutant SOD1 linked to familial amyotrophic lateral sclerosis

Biochemical and biophysical research communications, 2016-11, Vol.480 (3), p.422-428

2016

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Synthesis and evaluation of novel 2,4-diaminopyrimidines bearing bicyclic aminobenzazepines for anaplastic lymphoma kinase (ALK) inhibitor

Bioorganic & medicinal chemistry letters, 2015-09, Vol.25 (18), p.3992-3998

2015

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4-Substituted quinazoline derivatives as novel EphA2 receptor tyrosine kinase inhibitors

Bioorganic & medicinal chemistry letters, 2014-09, Vol.24 (17), p.4080-4083

2014

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Therapeutic Efficacy of ABN401, a Highly Potent and Selective MET Inhibitor, Based on Diagnostic Biomarker Test in MET-Addicted Cancer

Cancers, 2020-06, Vol.12 (6), p.1575

2020

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Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors

Bioorganic & medicinal chemistry letters, 2013-12, Vol.23 (24), p.6711-6716

2013

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Novel bis-ortho-alkoxy-para-piperazinesubstituted-2,4-dianilinopyrimidines (KRCA-0008) as potent and selective ALK inhibitors for anticancer treatment

Bioorganic & medicinal chemistry letters, 2013-11, Vol.23 (22), p.6192-6196

2013

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Synthesis and characterization of novel polyimides with 1-octadecyl side chains for liquid crystal alignment layers

Polymers for advanced technologies, 2007-03, Vol.18 (3), p.226-234

2007

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Development of potent ALK inhibitor and its molecular inhibitory mechanism against NSCLC harboring EML4-ALK proteins

Biochemical and biophysical research communications, 2015-08, Vol.464 (3), p.762-767

2015

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Facile synthesis of benzo[4,5]furo[3,2- c]pyridines via palladium-catalyzed intramolecular Heck reaction

Tetrahedron letters, 2009-08, Vol.50 (31), p.4492-4494

2009

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Total Synthesis of Clavepictines A and B. Diastereoselective Cyclization of δ-Aminoallenes

Journal of the American Chemical Society, 1999-11, Vol.121 (43), p.10012-10020

1999

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A Facile Synthesis of Cyclopenta[d][1,2]oxazines through [6+4] Cycloaddition Reaction

Bulletin of the Korean Chemical Society, 2006, 27(9), , pp.1481-1484

2006

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Induced protein degradation of anaplastic lymphoma kinase (ALK) by proteolysis targeting chimera (PROTAC)

Design and characterization of cereblon-mediated androgen receptor proteolysis-targeting chimeras

Combination Treatment with GSK126 and Pomalidomide Induces B-Cell Differentiation in EZH2 Gain-of-Function Mutant Diffuse Large B-Cell Lymphoma

Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors

Augmentation of the antitumor effects of PARP inhibitors in triple-negative breast cancer via degradation by hydrophobic tagging modulation

Cereblon contributes to cardiac dysfunction by degrading Cav1.2α

New Pyrimidine Derivatives possessing ALK Inhibitory Activities

Synthesis and structure–activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors

A Novel Series of Highly Potent Small Molecule Inhibitors of Rhinovirus Replication

Discovery of aminopyridines substituted with benzoxazole as orally active c-Met kinase inhibitors

Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera

Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors

Design and synthesis of triazolopyridazines substituted with methylisoquinolinone as selective c-Met kinase inhibitors

Replacing the terminal piperidine in ceritinib with aliphatic amines confers activities against crizotinib-resistant mutants including G1202R

cIAPs promote the proteasomal degradation of mutant SOD1 linked to familial amyotrophic lateral sclerosis

Synthesis and evaluation of novel 2,4-diaminopyrimidines bearing bicyclic aminobenzazepines for anaplastic lymphoma kinase (ALK) inhibitor

4-Substituted quinazoline derivatives as novel EphA2 receptor tyrosine kinase inhibitors

Therapeutic Efficacy of ABN401, a Highly Potent and Selective MET Inhibitor, Based on Diagnostic Biomarker Test in MET-Addicted Cancer

Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors

Novel bis-ortho-alkoxy-para-piperazinesubstituted-2,4-dianilinopyrimidines (KRCA-0008) as potent and selective ALK inhibitors for anticancer treatment

Synthesis and characterization of novel polyimides with 1-octadecyl side chains for liquid crystal alignment layers

Development of potent ALK inhibitor and its molecular inhibitory mechanism against NSCLC harboring EML4-ALK proteins

Facile synthesis of benzo[4,5]furo[3,2- c]pyridines via palladium-catalyzed intramolecular Heck reaction

Total Synthesis of Clavepictines A and B. Diastereoselective Cyclization of δ-Aminoallenes

A Facile Synthesis of Cyclopenta[d][1,2]oxazines through [6+4] Cycloaddition Reaction

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