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Rho GTPase Signaling in Platelet Regulation and Implication for Antiplatelet Therapies

International journal of molecular sciences, 2023-01, Vol.24 (3), p.2519

2023

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A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo

Molecular cancer therapeutics, 2012-08, Vol.11 (8), p.1672-1682

2012

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Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis

Scientific reports, 2021-06, Vol.11 (1), p.13170-13170, Article 13170

2021

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Towards increasing shelf life and haemostatic potency of stored platelet concentrates

Current opinion in hematology, 2018-11, Vol.25 (6), p.500-508

2018

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RhoA and Rac1 GTPases Differentially Regulate Agonist-Receptor Mediated Reactive Oxygen Species Generation in Platelets

PloS one, 2016-09, Vol.11 (9), p.e0163227-e0163227

2016

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Structure-Activity Relationship Analysis of Rhosin, a RhoA GTPase Inhibitor, Reveals a New Class of Antiplatelet Agents

International journal of molecular sciences, 2023-02, Vol.24 (4), p.4167

2023

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Gene targeting implicates Cdc42 GTPase in GPVI and non-GPVI mediated platelet filopodia formation, secretion and aggregation

PloS one, 2011-07, Vol.6 (7), p.e22117

2011

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Rational Design and Applications of a Rac GTPase–Specific Small Molecule Inhibitor

Methods in Enzymology, 2006, Vol.406, p.554-565

2006

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A novel small molecule 1,2,3,4,6-penta-O-galloyl-α-D-glucopyranose mimics the antiplatelet actions of insulin

PloS one, 2011-11, Vol.6 (11), p.e26238-e26238

2011

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Structure-Activity Relationship Analysis of Analogs of Rhosin, a RhoA Inhibitor, Reveals a New Generation of Improved Antiplatelet Agents

Blood, 2021-11, Vol.138 (Supplement 1), p.3989-3989

2021

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RhoA Targeting Suppresses Cold-Induced Platelet Lesion and Allows Refrigerated Storage of Functional Human Platelets to Fourteen Days

Blood, 2019-11, Vol.134 (Supplement_1), p.99-99

2019

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RhoA and Rac1 Gtpases Differentially Regulate Agonist-Receptor Mediated ROS Generation in Platelets

Blood, 2014-12, Vol.124 (21), p.2763-2763

2014

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Specific Pharmacologic Targeting of Rho GTPases Rac1, Cdc42 and RhoA Reveals Their Differential and Critical Roles In Regulation of Platelet Activation

Blood, 2010-11, Vol.116 (21), p.2019-2019

2010

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A Novel Small Molecule 1,2,3,4,6-penta-O-galloyl-[alpha]-D-glucopyranose Mimics the Antiplatelet Actions of Insulin

PloS one, 2011-11, Vol.6 (11), p.e26238

2011

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Abstract 3231: A small molecule inhibitor of glucose transporter 1 (Glut1) down-regulates glycolysis, induces cell cycle arrest, and inhibits cancer cell growth in vitro and in vivo

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.3231-3231

2012

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Abstract 4068: A novel antiglycolytic small compound inhibits cancer growth in vitro and in vivo by inhibiting glut1

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.4068-4068

2011

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Genetic and Pharmacologic Evidence Shows That Cdc42 GTPase Plays a Central Role in the Regulation of Both GPVI- and Non-GPVI-Dependent Activation of Platelets

Blood, 2009-11, Vol.114 (22), p.2997-2997

2009

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Mechanism of Human Platelet Activation by Endotoxic Glycolipid-Bearing Mutant Re595 of Salmonella minnesota

Blood, 1986-11, Vol.68 (5), p.1015-1023

1986

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Hypocholesterolemic and antiaggregatory properties of 2-hydroxytetronic acid redox analogs and their relationship to clofibric acid

Journal of medicinal chemistry, 1982-01, Vol.25 (1), p.90-93

1982

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Rac2 GTPase Plays a Critical Role in Platelet Adhesion as Well as in Sustenance and Perpetuation of Platelet Aggregation

Blood, 2004-11, Vol.104 (11), p.3523-3523

2004

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Investigation of the Role of Arachidonic Acid in Platelet Function and Mechanisms for Suppression of Prostaglandin Biosynthesis

British journal of haematology, 1978-05, Vol.39 (1), p.71-81

1978

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Further Evidence for the Role of Thrombin in the Platelet Release Reaction Caused by Various Agents, and the Nature of Biphasic Platelet Aggregation

British journal of haematology, 1978-03, Vol.38 (3), p.381-390

1978

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The effect of halofenate--free acid on aggregation--the release reaction, coagulant activity, and lipid metabolism of human platelets

Thrombosis and haemostasis, 1977-01, Vol.38 (3), p.612

1977

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Platelet activation in haemostasis: role of thrombin and other clotting factors in platelet-collagen interaction

Haemostasis, 1977, Vol.6 (1), p.59

1977

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Role of protein methylation in agonist-induced signal transduction in human platelets

SAAS bulletin, biochemistry and biotechnology, 1992-01, Vol.5, p.7

Huzoor-Akbar

1992

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Rho GTPase Signaling in Platelet Regulation and Implication for Antiplatelet Therapies

A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo

Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis

Towards increasing shelf life and haemostatic potency of stored platelet concentrates

RhoA and Rac1 GTPases Differentially Regulate Agonist-Receptor Mediated Reactive Oxygen Species Generation in Platelets

Structure-Activity Relationship Analysis of Rhosin, a RhoA GTPase Inhibitor, Reveals a New Class of Antiplatelet Agents

Gene targeting implicates Cdc42 GTPase in GPVI and non-GPVI mediated platelet filopodia formation, secretion and aggregation

Rational Design and Applications of a Rac GTPase–Specific Small Molecule Inhibitor

A novel small molecule 1,2,3,4,6-penta-O-galloyl-α-D-glucopyranose mimics the antiplatelet actions of insulin

Structure-Activity Relationship Analysis of Analogs of Rhosin, a RhoA Inhibitor, Reveals a New Generation of Improved Antiplatelet Agents

RhoA Targeting Suppresses Cold-Induced Platelet Lesion and Allows Refrigerated Storage of Functional Human Platelets to Fourteen Days

RhoA and Rac1 Gtpases Differentially Regulate Agonist-Receptor Mediated ROS Generation in Platelets

Specific Pharmacologic Targeting of Rho GTPases Rac1, Cdc42 and RhoA Reveals Their Differential and Critical Roles In Regulation of Platelet Activation

A Novel Small Molecule 1,2,3,4,6-penta-O-galloyl-[alpha]-D-glucopyranose Mimics the Antiplatelet Actions of Insulin

Abstract 3231: A small molecule inhibitor of glucose transporter 1 (Glut1) down-regulates glycolysis, induces cell cycle arrest, and inhibits cancer cell growth in vitro and in vivo

Abstract 4068: A novel antiglycolytic small compound inhibits cancer growth in vitro and in vivo by inhibiting glut1

Genetic and Pharmacologic Evidence Shows That Cdc42 GTPase Plays a Central Role in the Regulation of Both GPVI- and Non-GPVI-Dependent Activation of Platelets

Mechanism of Human Platelet Activation by Endotoxic Glycolipid-Bearing Mutant Re595 of Salmonella minnesota

Hypocholesterolemic and antiaggregatory properties of 2-hydroxytetronic acid redox analogs and their relationship to clofibric acid

Rac2 GTPase Plays a Critical Role in Platelet Adhesion as Well as in Sustenance and Perpetuation of Platelet Aggregation

Investigation of the Role of Arachidonic Acid in Platelet Function and Mechanisms for Suppression of Prostaglandin Biosynthesis

Further Evidence for the Role of Thrombin in the Platelet Release Reaction Caused by Various Agents, and the Nature of Biphasic Platelet Aggregation

The effect of halofenate--free acid on aggregation--the release reaction, coagulant activity, and lipid metabolism of human platelets

Platelet activation in haemostasis: role of thrombin and other clotting factors in platelet-collagen interaction

Role of protein methylation in agonist-induced signal transduction in human platelets

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