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A novel in vitro allometric scaling methodology for aldehyde oxidase substrates to enable selection of appropriate species for traditional allometry

Xenobiotica, 2018-03, Vol.48 (3), p.219-231

2018

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Aldehyde oxidase activity in donor-matched fresh and cryopreserved human hepatocytes and assessment of variability in 75 donors

Drug metabolism and disposition, 2014-06, Vol.42 (6), p.1090-1097

2014

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Cynomolgus monkey as a surrogate for human aldehyde oxidase metabolism of the EGFR inhibitor BIBX1382

Drug metabolism and disposition, 2014-10, Vol.42 (10), p.1751

2014

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Is 1-aminobenzotriazole an appropriate in vitro tool as a nonspecific cytochrome P450 inactivator?

Drug metabolism and disposition, 2009-01, Vol.37 (1), p.10-13

2009

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Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes

Drug metabolism and disposition, 2012-02, Vol.40 (2), p.267-275

2012

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Atypical kinetic profiles in drug metabolism reactions

Drug metabolism and disposition, 2002-04, Vol.30 (4), p.355-362

2002

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Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures

Drug metabolism and disposition, 2004-05, Vol.32 (5), p.512-518

2004

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Challenges and Opportunities with Non-CYP Enzymes Aldehyde Oxidase, Carboxylesterase, and UDP-Glucuronosyltransferase: Focus on Reaction Phenotyping and Prediction of Human Clearance

The AAPS journal, 2016-11, Vol.18 (6), p.1391-1405

2016

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Low-Turnover Drug Molecules: A Current Challenge for Drug Metabolism Scientists

Drug metabolism and disposition, 2015-12, Vol.43 (12), p.1917-1928

2015

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Mechanism-based inactivation of cytochrome P450 2C9 by tienilic acid and (+/-)-suprofen: a comparison of kinetics and probe substrate selection

Drug metabolism and disposition, 2009-01, Vol.37 (1), p.59-65

2009

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Effect of the Plasticizer DEHP in Blood Collection Bags on Human Plasma Fraction Unbound Determination for Alpha-1-Acid Glycoprotein (AAG) Binding Drugs

The AAPS journal, 2019-01, Vol.21 (1), p.5-5, Article 5

2019

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Assessment of the Biotransformation of Low-Turnover Drugs in the H µ REL Human Hepatocyte Coculture Model

Drug metabolism and disposition, 2018-11, Vol.46 (11), p.1617-1625

2018

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Polymorphic variants (CYP2C93 and CYP2C95) and the F114L active site mutation of CYP2C9: effect on atypical kinetic metabolism profiles

Drug metabolism and disposition, 2002-04, Vol.30 (4), p.385-390

2002

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In vitro-in vivo correlation and translation to the clinical outcome for CJ-13,610, a novel inhibitor of 5-lipoxygenase

Drug metabolism and disposition, 2010-07, Vol.38 (7), p.1113-1121

2010

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Activation of cytochrome P450 2C9-mediated metabolism: mechanistic evidence in support of kinetic observations

Archives of biochemistry and biophysics, 2003-02, Vol.410 (1), p.16-24

2003

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In vitro metabolism of clindamycin in human liver and intestinal microsomes

Drug metabolism and disposition, 2003-07, Vol.31 (7), p.878-887

2003

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Activation of CYP2C9-mediated metabolism by a series of dapsone analogs: kinetics and structural requirements

Drug metabolism and disposition, 2002-11, Vol.30 (11), p.1194-1200

2002

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A rapid cocktail LC–MS/MS method to assess inhibitor selectivity for cyp phenotyping in human liver microsomes and hepatocytes

Drug metabolism and pharmacokinetics, 2018-01, Vol.33 (1), p.S68-S69

2018

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Synthesis, SAR, and Series Evolution of Novel Oxadiazole-Containing 5‑Lipoxygenase Activating Protein Inhibitors: Discovery of 2‑[4-(3-{(R)‑1-[4-(2-Amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]‑N,N‑dimethyl-acetamide (BI 665915)

Journal of medicinal chemistry, 2015-02, Vol.58 (4), p.1669-1690

2015

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Visible spectra of type II cytochrome P450-drug complexes: evidence that "incomplete" heme coordination is common

Drug metabolism and disposition, 2007-04, Vol.35 (4), p.614-622

2007

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Discovery and optimization of oxadiazole-based FLAP inhibitors

Bioorganic & medicinal chemistry letters, 2017-10, Vol.27 (20), p.4652-4659

2017

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Time-dependent inhibition and estimation of CYP3A clinical pharmacokinetic drug-drug interactions using plated human cell systems

Drug metabolism and disposition, 2012-07, Vol.40 (7), p.1336-1344

2012

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Cynomolgus Monkey as a Surrogate for Human Aldehyde Oxidase Metabolism of the EGFR Inhibitor BIBX1382

Drug metabolism and disposition, 2014-10, Vol.42 (10), p.1751-1760

2014

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Dapsone activation of CYP2C9-mediated metabolism: evidence for activation of multiple substrates and a two-site model

Drug metabolism and disposition, 2001-07, Vol.29 (7), p.1029

2001

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Meet Our Editorial Board Member

Current drug metabolism, 2016-05, Vol.17 (6), p.519-519

Matthew Hutzler, J.

2016

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A novel in vitro allometric scaling methodology for aldehyde oxidase substrates to enable selection of appropriate species for traditional allometry

Aldehyde oxidase activity in donor-matched fresh and cryopreserved human hepatocytes and assessment of variability in 75 donors

Cynomolgus monkey as a surrogate for human aldehyde oxidase metabolism of the EGFR inhibitor BIBX1382

Is 1-aminobenzotriazole an appropriate in vitro tool as a nonspecific cytochrome P450 inactivator?

Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes

Atypical kinetic profiles in drug metabolism reactions

Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures

Challenges and Opportunities with Non-CYP Enzymes Aldehyde Oxidase, Carboxylesterase, and UDP-Glucuronosyltransferase: Focus on Reaction Phenotyping and Prediction of Human Clearance

Low-Turnover Drug Molecules: A Current Challenge for Drug Metabolism Scientists

Mechanism-based inactivation of cytochrome P450 2C9 by tienilic acid and (+/-)-suprofen: a comparison of kinetics and probe substrate selection

Effect of the Plasticizer DEHP in Blood Collection Bags on Human Plasma Fraction Unbound Determination for Alpha-1-Acid Glycoprotein (AAG) Binding Drugs

Assessment of the Biotransformation of Low-Turnover Drugs in the H µ REL Human Hepatocyte Coculture Model

Polymorphic variants (CYP2C93 and CYP2C95) and the F114L active site mutation of CYP2C9: effect on atypical kinetic metabolism profiles

In vitro-in vivo correlation and translation to the clinical outcome for CJ-13,610, a novel inhibitor of 5-lipoxygenase

Activation of cytochrome P450 2C9-mediated metabolism: mechanistic evidence in support of kinetic observations

In vitro metabolism of clindamycin in human liver and intestinal microsomes

Activation of CYP2C9-mediated metabolism by a series of dapsone analogs: kinetics and structural requirements

A rapid cocktail LC–MS/MS method to assess inhibitor selectivity for cyp phenotyping in human liver microsomes and hepatocytes

Synthesis, SAR, and Series Evolution of Novel Oxadiazole-Containing 5‑Lipoxygenase Activating Protein Inhibitors: Discovery of 2‑[4-(3-{(R)‑1-[4-(2-Amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]‑N,N‑dimethyl-acetamide (BI 665915)

Visible spectra of type II cytochrome P450-drug complexes: evidence that "incomplete" heme coordination is common

Discovery and optimization of oxadiazole-based FLAP inhibitors

Time-dependent inhibition and estimation of CYP3A clinical pharmacokinetic drug-drug interactions using plated human cell systems

Cynomolgus Monkey as a Surrogate for Human Aldehyde Oxidase Metabolism of the EGFR Inhibitor BIBX1382

Dapsone activation of CYP2C9-mediated metabolism: evidence for activation of multiple substrates and a two-site model

Meet Our Editorial Board Member

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