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Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, non-inferiority, randomised trial

The Lancet (British edition), 2015-05, Vol.385 (9982), p.2077-2087

2015

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Severe gastrointestinal toxicity with administration of trametinib in combination with dabrafenib and ipilimumab

Pigment cell and melanoma research, 2015-09, Vol.28 (5), p.611-612

2015

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Safety, Pharmacokinetics, and Pharmacodynamics of the TLR4 Agonist GSK1795091 in Healthy Individuals: Results from a Randomized, Double-blind, Placebo-controlled, Ascending Dose Study

Clinical therapeutics, 2020-08, Vol.42 (8), p.1519-1534.e33

2020

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A phase I ascending single-dose study of the safety, tolerability, and pharmacokinetics of bosutinib (SKI-606) in healthy adult subjects

Cancer chemotherapy and pharmacology, 2012-01, Vol.69 (1), p.221-227

2012

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Effect of Ketoconazole on the Pharmacokinetics of Oral Bosutinib in Healthy Subjects

Journal of clinical pharmacology, 2011-12, Vol.51 (12), p.1721-1727

2011

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Pharmacokinetics of oral neratinib during co‐administration of ketoconazole in healthy subjects

British journal of clinical pharmacology, 2011-04, Vol.71 (4), p.522-527

2011

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A Phase I, First‐in‐Human Study of GSK2849330, an Anti‐HER3 Monoclonal Antibody, in HER3‐Expressing Solid Tumors

The oncologist (Dayton, Ohio), 2021-10, Vol.26 (10), p.e1844-e1853

2021

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A randomized, crossover, placebo- and moxifloxacin-controlled study to evaluate the effects of bosutinib (SKI-606), a dual Src/Abl tyrosine kinase inhibitor, on cardiac repolarization in healthy adult subjects

International journal of cancer, 2012-08, Vol.131 (3), p.E304-E311

2012

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A double-blind, randomized, multiple-dose, parallel-group study to characterize the occurrence of diarrhea following two different dosing regimens of neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor

Cancer chemotherapy and pharmacology, 2012-07, Vol.70 (1), p.191-199

2012

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ETO interacting proteins

Oncogene, 2004-05, Vol.23 (24), p.4270-4274

2004

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Long-Range Disruption of Gene Expression by a Selectable Marker Cassette

Proceedings of the National Academy of Sciences - PNAS, 1996-11, Vol.93 (23), p.13090-13095

1996

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HDAC4: A corepressor controlling bone development

Cell, 2004-11, Vol.119 (4), p.448-449

Hug, Bruce A.

2004

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Fusion-Protein Truncation Provides New Insights into Leukemogenesis

Proceedings of the National Academy of Sciences - PNAS, 2004-12, Vol.101 (49), p.16985-16986

2004

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Characterization of tumor antigen expression and myeloid immune profiles to inform the development of immune stimulating antibody conjugates (ISACs)

Journal of clinical oncology, 2022-06, Vol.40 (16_suppl), p.2557-2557

2022

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Oligomerization of ETO Is Obligatory for Corepressor Interaction

Molecular and Cellular Biology, 2001-01, Vol.21 (1), p.156-163

2001

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A phase Ib single-arm study of bintrafusp alfa for the treatment of pretreated, locally advanced/unresectable or metastatic urothelial cancer

Journal of clinical oncology, 2021-02, Vol.39 (6_suppl), p.TPS501-TPS501

2021

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Cooperative function of Aml1-ETO corepressor recruitment domains in the expansion of primary bone marrow cells

Cancer research (Chicago, Ill.), 2002-05, Vol.62 (10), p.2906-2912

2002

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A Single-Dose, Crossover, Placebo- and Moxifloxacin-Controlled Study to Assess the Effects of Neratinib (HKI-272) on Cardiac Repolarization in Healthy Adult Subjects

Clinical cancer research, 2010-08, Vol.16 (15), p.4016-4023

2010

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Intravenous Temsirolimus in Cancer Patients: Clinical Pharmacology and Dosing Considerations

Seminars in oncology, 2009-12, Vol.36, p.S18-S25

2009

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Endothelial cells in physiology and in the pathophysiology of vascular disorders

Blood, 1998-05, Vol.91 (10), p.3527-3561

1998

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Randomized Phase IIIb Study Of Rapid Vitamin K Antagonist Reversal In Patients Requiring An Urgent Surgical Procedure: Four-Factor Prothrombin Complex Concentrate Is Superior To Plasma

Blood, 2013-11, Vol.122 (21), p.3588-3588

2013

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Pharmacokinetic Profile of Temsirolimus With Concomitant Administration of Cytochrome P450-Inducing Medications

Journal of clinical pharmacology, 2007-11, Vol.47 (11), p.1430-1439

2007

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Abstract 2911: The CEA-targeted ISAC, BDC-2034, shows preclinical efficacy associated with innate immune activation, phagocytosis, and myeloid reprogramming

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.2911-2911

2022

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Abstract 4252: PD-L1-targeted ISAC combines myeloid cell activation, immune-checkpoint inhibition and ADCP to improve anti-tumor efficacy over anti-PD-L1 antibodies in preclinical models

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.4252-4252

2022

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A single-dose placebo- and moxifloxacin-controlled study of the effects of temsirolimus on cardiac repolarization in healthy adults

Cancer chemotherapy and pharmacology, 2012-06, Vol.69 (6), p.1433-1442

2012

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Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, non-inferiority, randomised trial

Severe gastrointestinal toxicity with administration of trametinib in combination with dabrafenib and ipilimumab

Safety, Pharmacokinetics, and Pharmacodynamics of the TLR4 Agonist GSK1795091 in Healthy Individuals: Results from a Randomized, Double-blind, Placebo-controlled, Ascending Dose Study

A phase I ascending single-dose study of the safety, tolerability, and pharmacokinetics of bosutinib (SKI-606) in healthy adult subjects

Effect of Ketoconazole on the Pharmacokinetics of Oral Bosutinib in Healthy Subjects

Pharmacokinetics of oral neratinib during co‐administration of ketoconazole in healthy subjects

A Phase I, First‐in‐Human Study of GSK2849330, an Anti‐HER3 Monoclonal Antibody, in HER3‐Expressing Solid Tumors

A randomized, crossover, placebo- and moxifloxacin-controlled study to evaluate the effects of bosutinib (SKI-606), a dual Src/Abl tyrosine kinase inhibitor, on cardiac repolarization in healthy adult subjects

A double-blind, randomized, multiple-dose, parallel-group study to characterize the occurrence of diarrhea following two different dosing regimens of neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor

ETO interacting proteins

Long-Range Disruption of Gene Expression by a Selectable Marker Cassette

HDAC4: A corepressor controlling bone development

Fusion-Protein Truncation Provides New Insights into Leukemogenesis

Characterization of tumor antigen expression and myeloid immune profiles to inform the development of immune stimulating antibody conjugates (ISACs)

Oligomerization of ETO Is Obligatory for Corepressor Interaction

A phase Ib single-arm study of bintrafusp alfa for the treatment of pretreated, locally advanced/unresectable or metastatic urothelial cancer

Cooperative function of Aml1-ETO corepressor recruitment domains in the expansion of primary bone marrow cells

A Single-Dose, Crossover, Placebo- and Moxifloxacin-Controlled Study to Assess the Effects of Neratinib (HKI-272) on Cardiac Repolarization in Healthy Adult Subjects

Intravenous Temsirolimus in Cancer Patients: Clinical Pharmacology and Dosing Considerations

Endothelial cells in physiology and in the pathophysiology of vascular disorders

Randomized Phase IIIb Study Of Rapid Vitamin K Antagonist Reversal In Patients Requiring An Urgent Surgical Procedure: Four-Factor Prothrombin Complex Concentrate Is Superior To Plasma

Pharmacokinetic Profile of Temsirolimus With Concomitant Administration of Cytochrome P450-Inducing Medications

Abstract 2911: The CEA-targeted ISAC, BDC-2034, shows preclinical efficacy associated with innate immune activation, phagocytosis, and myeloid reprogramming

Abstract 4252: PD-L1-targeted ISAC combines myeloid cell activation, immune-checkpoint inhibition and ADCP to improve anti-tumor efficacy over anti-PD-L1 antibodies in preclinical models

A single-dose placebo- and moxifloxacin-controlled study of the effects of temsirolimus on cardiac repolarization in healthy adults

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