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EMT is the dominant program in human colon cancer

BMC genomics, 2011-01, Vol.4 (1), p.9-9, Article 9

2011

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Targeted anti-mitotic therapies: can we improve on tubulin agents?

Nature reviews. Cancer, 2007-02, Vol.7 (2), p.107-117

2007

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The nervous system: Orchestra conductor in cancer, regeneration, inflammation and immunity

FASEB bioAdvances, 2021-11, Vol.3 (11), p.944-952

2021

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Double down for a double win

Clinical cancer research, 2012-04, Vol.18 (8), p.2124-2126

Huang, Pearl S

2012

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Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

Cancer research (Chicago, Ill.), 2008-04, Vol.68 (7), p.2366-2374

2008

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Antitumor activity of an allosteric inhibitor of centromere-associated protein-E

Proceedings of the National Academy of Sciences - PNAS, 2010-03, Vol.107 (13), p.5839-5844

2010

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Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885

Cancer research (Chicago, Ill.), 2006-12, Vol.66 (23), p.11100-11105

2006

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ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism

Nature chemical biology, 2007-11, Vol.3 (11), p.722-726

2007

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Drug-targeting strategies in cancer therapy

Current Opinion in Genetics & Development, 2001-02, Vol.11 (1), p.104-110

2001

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Mechanism of Inhibition of Human KSP by Monastrol: Insights from Kinetic Analysis and the Effect of Ionic Strength on KSP Inhibition

Biochemistry (Easton), 2004-12, Vol.43 (48), p.15258-15266

2004

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Conformation-Dependent Ligand Regulation of ATP Hydrolysis by Human KSP: Activation of Basal Hydrolysis and Inhibition of Microtubule-Stimulated Hydrolysis by a Single, Small Molecule Modulator

Journal of the American Chemical Society, 2008-06, Vol.130 (24), p.7584-7591

2008

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A proposal： a comprehensive platform to characterize tumors in Chinese and improve success in cancer drug discovery and development

Ai zheng, 2011-06, Vol.30 (6), p.363-367

2011

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Can phenotypic pathway signatures improve the prediction of response to PI3K pathway inhibitors?

Drug discovery today. Therapeutic strategies, 2009-06, Vol.6 (2), p.57-62

2009

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Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product

Nature (London), 1991-07, Vol.352 (6332), p.251-254

1991

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A method for determining intracellular concentrations of enzyme substrates from a combination of competitive inhibition and mutagenesis studies

Analytical biochemistry, 2005-02, Vol.337 (2), p.351-353

2005

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Leading the way to the next generation of anti-mitotics

Nature (London), 2003-04, Vol.422 (6933), p.781-781

2003

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Oncogene products as therapeutic targets for cancer

Current opinion in oncology, 1997-01, Vol.9 (1), p.94-100

1997

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Development of a Binding Assay for p53/HDM2 by Using Homogeneous Time-Resolved Fluorescence

Analytical biochemistry, 2000-02, Vol.278 (1), p.29-38

2000

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An SH3 domain is required for the mitogenic activity of microinjected phospholipase C-γ1

FEBS letters, 1995-01, Vol.358 (3), p.287-292

1995

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Protein domains governing interactions between E2F, the retinoblastoma gene product, and human papillomavirus type 16 E7 protein

Molecular and Cellular Biology, 1993-02, Vol.13 (2), p.953-960

1993

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Transcription Factor E2F Binds DNA as a Heterodimer

Proceedings of the National Academy of Sciences - PNAS, 1993-04, Vol.90 (8), p.3525-3529

1993

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A proposal: a comprehensive platform to characterize tumors in Chinese and improve success in cancer drug discovery and development

Ai zheng, 2011-06, Vol.30 (6), p.363-367

2011

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Retinoblastoma protein reverses DNA bending by transcription factor E2F

The Journal of biological chemistry, 1994-03, Vol.269 (9), p.6999-7005

1994

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3 - Strategies to Target Chemotherapeutics to Tumors

Novel Anticancer Agents, 2006, p.83-92

2006

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1203 NEUROGENIC MEDIATION OF AUGMENTED SURFACTANT SECRETION AT BIRTH

Pediatric research, 1978-04, Vol.12, p.564-564

1978

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EMT is the dominant program in human colon cancer

Targeted anti-mitotic therapies: can we improve on tubulin agents?

The nervous system: Orchestra conductor in cancer, regeneration, inflammation and immunity

Double down for a double win

Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

Antitumor activity of an allosteric inhibitor of centromere-associated protein-E

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885

ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism

Drug-targeting strategies in cancer therapy

Mechanism of Inhibition of Human KSP by Monastrol: Insights from Kinetic Analysis and the Effect of Ionic Strength on KSP Inhibition

Conformation-Dependent Ligand Regulation of ATP Hydrolysis by Human KSP: Activation of Basal Hydrolysis and Inhibition of Microtubule-Stimulated Hydrolysis by a Single, Small Molecule Modulator

A proposal： a comprehensive platform to characterize tumors in Chinese and improve success in cancer drug discovery and development

Can phenotypic pathway signatures improve the prediction of response to PI3K pathway inhibitors?

Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product

A method for determining intracellular concentrations of enzyme substrates from a combination of competitive inhibition and mutagenesis studies

Leading the way to the next generation of anti-mitotics

Oncogene products as therapeutic targets for cancer

Development of a Binding Assay for p53/HDM2 by Using Homogeneous Time-Resolved Fluorescence

An SH3 domain is required for the mitogenic activity of microinjected phospholipase C-γ1

Protein domains governing interactions between E2F, the retinoblastoma gene product, and human papillomavirus type 16 E7 protein

Transcription Factor E2F Binds DNA as a Heterodimer

A proposal: a comprehensive platform to characterize tumors in Chinese and improve success in cancer drug discovery and development

Retinoblastoma protein reverses DNA bending by transcription factor E2F

3 - Strategies to Target Chemotherapeutics to Tumors

1203 NEUROGENIC MEDIATION OF AUGMENTED SURFACTANT SECRETION AT BIRTH

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