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An “EAR” on Environmental Surveillance and Monitoring: A Case Study on the Use of Exposure–Activity Ratios (EARs) to Prioritize Sites, Chemicals, and Bioactivities of Concern in Great Lakes Waters

Environmental science & technology, 2017-08, Vol.51 (15), p.8713-8724

2017

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Limited Chemical Structural Diversity Found to Modulate Thyroid Hormone Receptor in the Tox21 Chemical Library

Environmental health perspectives, 2019-09, Vol.127 (9), p.97009

2019

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A gene expression biomarker for predictive toxicology to identify chemical modulators of NF-κB

PloS one, 2022-02, Vol.17 (2), p.e0261854-e0261854

2022

Volltextzugriff (PDF)

Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data

Environmental health perspectives, 2010-12, Vol.118 (12), p.1714-1720

2010

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The ToxCast Program for Prioritizing Toxicity Testing of Environmental Chemicals

Toxicological sciences, 2007-01, Vol.95 (1), p.5-12

2007

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Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway

Scientific reports, 2014-07, Vol.4 (1), p.5664, Article 5664

2014

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Chemical Genomics Profiling of Environmental Chemical Modulation of Human Nuclear Receptors

Environmental health perspectives, 2011-08, Vol.119 (8), p.1142-1148

2011

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Estimating Toxicity-Related Biological Pathway Altering Doses for High-Throughput Chemical Risk Assessment

Chemical research in toxicology, 2011-04, Vol.24 (4), p.451-462

2011

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Comprehensive assessment of NR ligand polypharmacology by a multiplex reporter NR assay

Scientific reports, 2022-02, Vol.12 (1), p.3115-3115, Article 3115

2022

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Impact of Environmental Chemicals on Key Transcription Regulators and Correlation to Toxicity End Points within EPA’s ToxCast Program

Chemical research in toxicology, 2010-03, Vol.23 (3), p.578-590

2010

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Analysis of Eight Oil Spill Dispersants Using Rapid, In Vitro Tests for Endocrine and Other Biological Activity

Environmental science & technology, 2010-08, Vol.44 (15), p.5979-5985

2010

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Identifying Environmental Chemicals as Agonists of the Androgen Receptor by Using a Quantitative High-throughput Screening Platform

Toxicology (Amsterdam), 2017-06, Vol.385, p.48-58

2017

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Understanding mechanisms of toxicity: Insights from drug discovery research

Toxicology and applied pharmacology, 2008-03, Vol.227 (2), p.163-178

2008

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In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis

Toxicological sciences, 2013-01, Vol.131 (1), p.40-55

2013

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Dosimetric anchoring of in vivo and in vitro studies for perfluorooctanoate and perfluorooctanesulfonate

Toxicological sciences, 2013-12, Vol.136 (2), p.308-327

2013

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High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures

NPJ systems biology and applications, 2021-01, Vol.7 (1), p.7-15, Article 7

2021

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Bioactivity profiling of per- and polyfluoroalkyl substances (PFAS) identifies potential toxicity pathways related to molecular structure

Toxicology (Amsterdam), 2021-06, Vol.457, p.152789, Article 152789

2021

Volltextzugriff (PDF)

A Roadmap to the Structure-Related Metabolism Pathways of Per- and Polyfluoroalkyl Substances in the Early Life Stages of Zebrafish ( Danio rerio )

Environmental health perspectives, 2021-07, Vol.129 (7), p.77004

2021

Volltextzugriff (PDF)

The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology

Chemical research in toxicology, 2021-02, Vol.34 (2), p.189-216

2021

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Nontarget Screening of Per- and Polyfluoroalkyl Substances Binding to Human Liver Fatty Acid Binding Protein

Environmental science & technology, 2020-05, Vol.54 (9), p.5676-5686

2020

Volltextzugriff (PDF)

Evaluating biological activity of compounds by transcription factor activity profiling

Science advances, 2018-09, Vol.4 (9), p.eaar4666-eaar4666

2018

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Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor

Toxicological sciences, 2015-11, Vol.148 (1), p.137-154

2015

Volltextzugriff (PDF)

Potential Toxicity of Complex Mixtures in Surface Waters from a Nationwide Survey of United States Streams: Identifying in Vitro Bioactivities and Causative Chemicals

Environmental science & technology, 2019-01, Vol.53 (2), p.973-983

2019

Volltextzugriff (PDF)

Characterization of physicochemical properties of nanomaterials and their immediate environments in high-throughput screening of nanomaterial biological activity

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology, 2013-09, Vol.5 (5), p.430-448

2013

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Environmental surveillance and monitoring-The next frontiers for high-throughput toxicology

Environmental toxicology and chemistry, 2016-03, Vol.35 (3), p.513-525

2016

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An “EAR” on Environmental Surveillance and Monitoring: A Case Study on the Use of Exposure–Activity Ratios (EARs) to Prioritize Sites, Chemicals, and Bioactivities of Concern in Great Lakes Waters

Limited Chemical Structural Diversity Found to Modulate Thyroid Hormone Receptor in the Tox21 Chemical Library

A gene expression biomarker for predictive toxicology to identify chemical modulators of NF-κB

Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data

The ToxCast Program for Prioritizing Toxicity Testing of Environmental Chemicals

Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway

Chemical Genomics Profiling of Environmental Chemical Modulation of Human Nuclear Receptors

Estimating Toxicity-Related Biological Pathway Altering Doses for High-Throughput Chemical Risk Assessment

Comprehensive assessment of NR ligand polypharmacology by a multiplex reporter NR assay

Impact of Environmental Chemicals on Key Transcription Regulators and Correlation to Toxicity End Points within EPA’s ToxCast Program

Analysis of Eight Oil Spill Dispersants Using Rapid, In Vitro Tests for Endocrine and Other Biological Activity

Identifying Environmental Chemicals as Agonists of the Androgen Receptor by Using a Quantitative High-throughput Screening Platform

Understanding mechanisms of toxicity: Insights from drug discovery research

In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis

Dosimetric anchoring of in vivo and in vitro studies for perfluorooctanoate and perfluorooctanesulfonate

High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures

Bioactivity profiling of per- and polyfluoroalkyl substances (PFAS) identifies potential toxicity pathways related to molecular structure

A Roadmap to the Structure-Related Metabolism Pathways of Per- and Polyfluoroalkyl Substances in the Early Life Stages of Zebrafish ( Danio rerio )

The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology

Nontarget Screening of Per- and Polyfluoroalkyl Substances Binding to Human Liver Fatty Acid Binding Protein

Evaluating biological activity of compounds by transcription factor activity profiling

Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor

Potential Toxicity of Complex Mixtures in Surface Waters from a Nationwide Survey of United States Streams: Identifying in Vitro Bioactivities and Causative Chemicals

Characterization of physicochemical properties of nanomaterials and their immediate environments in high-throughput screening of nanomaterial biological activity

Environmental surveillance and monitoring-The next frontiers for high-throughput toxicology

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