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Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice

Nature communications, 2017-02, Vol.8 (1), p.14572-14572, Article 14572

2017

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Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors

Proceedings of the National Academy of Sciences - PNAS, 2015-08, Vol.112 (32), p.E4410-E4417

2015

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Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

Nature chemical biology, 2016-10, Vol.12 (10), p.779

2016

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Gabapentin and intrathecal morphine combination therapy results in decreased oral narcotic use and more consistent pain scores after posterior spinal fusion for adolescent idiopathic scoliosis

Journal of orthopaedic surgery and research, 2021-11, Vol.16 (1), p.672-672, Article 672

2021

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Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State

Cell metabolism, 2018-09, Vol.28 (3), p.383-399.e9

2018

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Intravenous ondansetron reduced nausea but not pruritus following intrathecal morphine in children: Interim results of a randomized, double‐blinded, placebo‐control trial

Pediatric anesthesia, 2022-10, Vol.32 (10), p.1151-1158

2022

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The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function

Cell reports (Cambridge), 2018-10, Vol.25 (1), p.80-94

2018

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A retrospective comparison of intrathecal morphine and epidural hydromorphone for analgesia following posterior spinal fusion in adolescents with idiopathic scoliosis

Pediatric anesthesia, 2017-01, Vol.27 (1), p.91-97

2017

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Intrathecal Morphine and Oral Analgesics Provide Safe and Effective Pain Control After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis

Spine (Philadelphia, Pa. 1976), 2018-01, Vol.43 (2), p.E98-E104

2018

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MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade

Immunity (Cambridge, Mass.), 2016-03, Vol.44 (3), p.609-621

2016

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Comparing Peak Burn Injury Times and Characteristics in Australia and New Zealand

International journal of environmental research and public health, 2022-08, Vol.19 (15), p.9578

2022

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Targeting Activated Akt with GDC-0068, a Novel Selective Akt Inhibitor That Is Efficacious in Multiple Tumor Models

Clinical cancer research, 2013-04, Vol.19 (7), p.1760-1772

2013

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Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα

Journal of medicinal chemistry, 2022-12, Vol.65 (24), p.16589-16621

2022

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RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy

Cancer discovery, 2022-01, Vol.12 (1), p.204-219

2022

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Abstract P3-11-23: GDC-0077 is a selective PI3K alpha inhibitor with robust efficacy in PIK3CA mutant hormone-positive breast cancer models

Cancer research (Chicago, Ill.), 2020-02, Vol.80 (4_Supplement), p.P3-P3-11-23

2020

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Intraoperative Dexmedetomidine has no Effect on Postoperative Pain Scores for Posterior Spinal Fusion

The Open Anesthesia Journal, 2021-02, Vol.15 (1), p.1-6

2021

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Narcotic-only Epidural Infusion for Posterior Spinal Fusion Patients: A Single-Center, Retrospective Review

Journal of pediatric orthopaedics, 2016-07, Vol.36 (5), p.526-529

2016

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Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase

Bioorganic & medicinal chemistry letters, 2022-01, Vol.59 (C)

2022

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Bcl-2/Bcl-xL inhibition increases the efficacy of MEK inhibition alone and in combination with PI3 kinase inhibition in lung and pancreatic tumor models

Molecular cancer therapeutics, 2013-06, Vol.12 (6), p.853-864

2013

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Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase

Bioorganic & medicinal chemistry letters, 2022-03, Vol.59 (C), p.128576-128576, Article 128576

2022

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Abstract 146: The PI3K inhibitor, taselisib, has a unique mechanism of action that leads to enhanced potency in PIK3CA mutant models

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.146-146

2017

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Abstract 370: The PI3K inhibitor, taselisib (GDC-0032), has enhanced potency in PIK3CA mutant models through a unique mechanism of action

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.370-370

2016

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Abstract 156: Preclinical characterization of GDC-0077, a specific PI3K alpha inhibitor in early clinical development

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.156-156

2017

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Abstract 2672: Characterization of the enhanced potency of PI3K inhibitor taselisib (GDC-0032) in PI3K mutant cell lines and models

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.2672-2672

2015

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Abstract B190: GDC-0068 is a novel and selective Akt inhibitor that enhances the efficacy of FOLFOX in primary gastric cancer models

Molecular cancer therapeutics, 2013-11, Vol.12 (11_Supplement), p.B190-B190

2013

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