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Discovery of Potent Nonpeptide Inhibitors of Stromelysin Using SAR by NMR

Journal of the American Chemical Society, 1997-06, Vol.119 (25), p.5818-5827

1997

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Amyloid-beta aggregation: selective inhibition of aggregation in mixtures of amyloid with different chain lengths

Biophysical journal, 1994-09, Vol.67 (3), p.1216-1228

1994

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Clusterin (apoJ) Alters the Aggregation of Amyloid β-Peptide (Aβ 1-42) and Forms Slowly Sedimenting Aβ Complexes That Cause Oxidative Stress

Experimental neurology, 1995-11, Vol.136 (1), p.22-31

1995

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Cleavage at the amino and carboxyl termini of Alzheimer's amyloid-beta by cathepsin D

The Journal of biological chemistry, 1994-07, Vol.269 (28), p.18422-18428

1994

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NMR-Based Discovery of Lead Inhibitors That Block DNA Binding of the Human Papillomavirus E2 Protein

Journal of medicinal chemistry, 1997-09, Vol.40 (20), p.3144-3150

1997

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Variants in Apaf-1 segregating with major depression promote apoptosome function

Molecular psychiatry, 2006-01, Vol.11 (1), p.76-85

2006

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Design of Adenosine Kinase Inhibitors from the NMR-Based Screening of Fragments

Journal of medicinal chemistry, 2000-12, Vol.43 (25), p.4781-4786

2000

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NMR studies of [U-13C] cyclosporin A bound to cyclophilin: bound conformation and portions of cyclosporin involved in binding

Biochemistry (Easton), 1991-07, Vol.30 (26), p.6574-6583

1991

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Stromelysin Inhibitors Designed from Weakly Bound Fragments: Effects of Linking and Cooperativity

Journal of the American Chemical Society, 1997-06, Vol.119 (25), p.5828-5832

1997

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Equilibrium denaturation of recombinant human FK binding protein in urea

Biochemistry (Easton), 1993-03, Vol.32 (8), p.1920-1927

1993

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Isotope-Edited NMR of Cyclosporin A Bound to Cyclophilin: Evidence for a Trans 9,10 Amide Bond

Science (American Association for the Advancement of Science), 1990-12, Vol.250 (4986), p.1406-1409

1990

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The nanometer-scale structure of amyloid-beta visualized by atomic force microscopy

Journal of protein chemistry, 1996-02, Vol.15 (2), p.193-203

1996

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β/A4-evoked degeneration of differentiated SH-SY5Y human neuroblastoma cells

Journal of neuroscience research, 1994-11, Vol.39 (4), p.377-385

1994

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Abrogation of G2 checkpoint specifically sensitize p53 defective cells to cancer chemotherapeutic agents

Anticancer research, 2001-01, Vol.21 (1A), p.23

2001

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Complement C1q Does Not Bind Monomeric β-Amyloid

Experimental neurology, 1994-07, Vol.128 (1), p.136-142

1994

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A Continuous Fluorescence Assay of Renin Activity

Analytical biochemistry, 1993-05, Vol.210 (2), p.351-359

1993

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Substrate requirements for ErmC' methyltransferase activity

Journal of Bacteriology, 1995-08, Vol.177 (15), p.4327-4332

1995

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Driving affinity selection by centrifugal force

Assay and drug development technologies, 2003-08, Vol.1 (4), p.507-519

2003

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Preliminary characterization of a cloned neutral isoelectric form of the human peptidyl prolyl isomerase cyclophilin

The Journal of biological chemistry, 1991-02, Vol.266 (4), p.2474-2479

1991

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Solution structure of the cyclosporin A/cyclophilin complex by NMR

Nature (London), 1993-01, Vol.361 (6407), p.88-91

1993

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Inhibitor stabilization of human immunodeficiency virus type-2 proteinase dimer formation

The Journal of biological chemistry, 1991-10, Vol.266 (29), p.19217-19220

1991

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NMR studies of an FK-506 analog [U-13C]ascomycin, bound to FKBP: conformation and regions of ascomycin involved in binding

Journal of medicinal chemistry, 1991-09, Vol.34 (9), p.2925-2928

1991

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Crystal Structure of ErmC‘, an rRNA Methyltransferase Which Mediates Antibiotic Resistance in Bacteria

Biochemistry (Easton), 1998-05, Vol.37 (20), p.7103-7112

1998

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Domain structure analysis of elongation factor‐3 from saccharomyces cerevisiae by limited proteolysis and differential scanning calorimetry

Protein science, 1998-12, Vol.7 (12), p.2595-2601

1998

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The kinetics of bovine growth hormone folding are consistent with a framework model

The Journal of biological chemistry, 1987-02, Vol.262 (6), p.2590-2596

1987

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Discovery of Potent Nonpeptide Inhibitors of Stromelysin Using SAR by NMR

Amyloid-beta aggregation: selective inhibition of aggregation in mixtures of amyloid with different chain lengths

Clusterin (apoJ) Alters the Aggregation of Amyloid β-Peptide (Aβ 1-42) and Forms Slowly Sedimenting Aβ Complexes That Cause Oxidative Stress

Cleavage at the amino and carboxyl termini of Alzheimer's amyloid-beta by cathepsin D

NMR-Based Discovery of Lead Inhibitors That Block DNA Binding of the Human Papillomavirus E2 Protein

Variants in Apaf-1 segregating with major depression promote apoptosome function

Design of Adenosine Kinase Inhibitors from the NMR-Based Screening of Fragments

NMR studies of [U-13C] cyclosporin A bound to cyclophilin: bound conformation and portions of cyclosporin involved in binding

Stromelysin Inhibitors Designed from Weakly Bound Fragments: Effects of Linking and Cooperativity

Equilibrium denaturation of recombinant human FK binding protein in urea

Isotope-Edited NMR of Cyclosporin A Bound to Cyclophilin: Evidence for a Trans 9,10 Amide Bond

The nanometer-scale structure of amyloid-beta visualized by atomic force microscopy

β/A4-evoked degeneration of differentiated SH-SY5Y human neuroblastoma cells

Abrogation of G2 checkpoint specifically sensitize p53 defective cells to cancer chemotherapeutic agents

Complement C1q Does Not Bind Monomeric β-Amyloid

A Continuous Fluorescence Assay of Renin Activity

Substrate requirements for ErmC' methyltransferase activity

Driving affinity selection by centrifugal force

Preliminary characterization of a cloned neutral isoelectric form of the human peptidyl prolyl isomerase cyclophilin

Solution structure of the cyclosporin A/cyclophilin complex by NMR

Inhibitor stabilization of human immunodeficiency virus type-2 proteinase dimer formation

NMR studies of an FK-506 analog [U-13C]ascomycin, bound to FKBP: conformation and regions of ascomycin involved in binding

Crystal Structure of ErmC‘, an rRNA Methyltransferase Which Mediates Antibiotic Resistance in Bacteria

Domain structure analysis of elongation factor‐3 from saccharomyces cerevisiae by limited proteolysis and differential scanning calorimetry

The kinetics of bovine growth hormone folding are consistent with a framework model

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